DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and enpep

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	XP_002934295.1	Gene:	enpep / 100494326	XenbaseID:	XB-GENE-977050	Length:	965	Species:	Xenopus tropicalis

Alignment Length:	1011	Identity:	313/1011 - (30%)
Similarity:	511/1011 - (50%)	Gaps:	102/1011 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 DKTTSVKHLFRAESGHLNALISSKQFVKVQKQFYRDFSSVSLGA------PLKSSDAPLLGDLCS 161
            |...|.|:..|..  |:..::.:...|.|         ||.||.      |.||::..:.....:
Frog    12 DGMQSKKYCIRGM--HVAIIVGAVVVVGV---------SVGLGVGLTRPDPCKSNNGDVTTTTTT 65

  Fly   162 QYRAILAHTSADVIPGQDRHHPGCNYQQIRRAHTQLLSKEQQLEQERKMAQKAKFERLPTNVVPR 226
            :...:|:..:..|.|    .|..|             .|......:.|     :| ||||.:.|.
Frog    66 RTTTVLSPATTPVPP----EHEVC-------------PKRDDSNGDWK-----EF-RLPTYINPV 107

  Fly   227 HYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDI-VLDSVELHFECSKLKPEKIVYSAEN 290
            ||.:.|.|.:::.|:.|...:.:.:.:.:..:.|:..:. ::..:.|.....::..::......|
Frog   108 HYNVELHPVMEQDTYNGTVSIWLRLSKTSKHLWLHLRETKIIGQLTLTRGSQQIPIQQCFQYIPN 172

  Fly   291 ETATLEFAQEI-----PAETQGV--LHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATD 348
            |...|| ||::     |.:....  |.:.|.|.|:..:.||||:.| ..||..:.......|.||
Frog   173 EYLVLE-AQQVLDPNSPTDENDTYCLTLQFAGRLDGSLVGFYRTTY-QENGVTKSIAAADHEPTD 235

  Fly   349 ARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRRVRFDRTPIMSTYLVAVVV 413
            ||:.|||:|||..|||:.|:::..::..|:|||||.:..:|.:|.:|..|:::..||||||...|
Frog   236 ARKSFPCFDEPNKKATYTISIIHREEYDAISNMPVQESVALGNGWKRTLFEKSVPMSTYLVCFAV 300

  Fly   414 GEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSA 478
            .::.|||..|..||.:|::....:.....:|......|..::::|||:.|.|||:|.|||.||..
Frog   301 HQFKYVERLSKRGVPLRIYVQPLQNATAEYAANTTKIVFDFFEEYFNMPYSLPKLDQIAIPDFGT 365

  Fly   479 GAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASF 543
            ||||||||:|||||.:|.||..::.:.||.:|..:.||:.||||||:|||:||..||||||:|||
Frog   366 GAMENWGLITYRETNLLYDPNESATVNKQRVAAVIAHELVHQWFGNIVTMDWWDDLWLNEGFASF 430

  Fly   544 VEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVI 608
            .|:..|....|.:::..|.:.|.....:..|:|.:||||.|.|..|:||..:||.||||||||::
Frog   431 FEYSGVDAAEPLWNMLDQILIDDLLPVMRDDALLSSHPIIVTVSTPAEITSVFDAISYNKGASIL 495

  Fly   609 RMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSKNVSDVMTSWTQHKGFPVVSVES 673
            |||.|:|..:.|:||...||..:.:.|..|:|.|.:|.:||.|.|.:||.:||:..|:||::|||
Frog   496 RMLEDWISPENFKKGCQDYLKDYVFKNAKTDDFWNSLAKASGKPVKEVMDTWTRQMGYPVLNVES 560

  Fly   674 EQTSKNQRLLRLKQCKFTADGS------QADENCLWVVPISVSTSKNPTGIAKTFLLDKS---SM 729
            ..|        :||.:|..|.:      .::.|.:|.:|::...:.|  .:....|.:||   .:
Frog   561 LNT--------VKQTRFLLDPNANALEPPSEFNYMWNIPVTFYATNN--SVDYNLLYNKSIPAGL 615

  Fly   730 EVTLDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVEKME--LPPLDRLGLIDDMFAMVQAG 792
            .:|..|...|.::|||...:|::|..|......||...:|...  ....||.|||||.||:.:|.
Frog   616 SLTPFNDATDGFLKINTRHLGFFRVNYELSTWNQLSALLEANHETFTDADRAGLIDDAFALARAE 680

  Fly   793 HASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDLMED-------FHRFGRNLYEPVA 850
            .......|.:......||||..||...:||..|      :|::||       |..:.|...:|:.
Frog   681 KLDYNISLDITKYLEKETNYLTWTRAISSLAYL------SDMLEDDNTIYPKFQEYLRKQVKPIT 739

  Fly   851 YRLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHVNGTELLPADLRTTCYK-AV 914
            .:.|||  |..:.:|.|||:.||.........|.:.||...||..:.| :.:|.:||...|: .:
Frog   740 QKHGWE--DTGSDIDKLLRASVLALSCKMGDPDALNEASRLFRDWIGG-KSIPVNLRQLVYRYGM 801

  Fly   915 LQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAM-SSEVRAQDSVFVIVA 978
            .|.|:::.:|.|...|..|.|.:|::::.:.|....:::|:.|.:.... :|.:::||::.||..
Frog   802 QQSGNQESWNYMFQQYLTTSLAQEKEKLLQGLASANNIELIDRYLKLIYNTSLIKSQDALNVIYY 866

  Fly   979 VAI-NPKGRDMAWEFFKENNKQLLERYQ-GGFLLSRLIKYLIENFASEERAKEVEEFLQ------ 1035
            ::: :..|:.|||::.:.|...|::||. ....|.|::..:...|.:..:..::|.|.:
Frog   867 ISVYSQYGKQMAWDWVRINWDYLVDRYNINDRNLGRIVTRISGTFNTATQLWQMENFFEKYPNAG 931

  Fly  1036 VNQIPGCERTVSQAVETIRLNAAWLQRDREQLAIFL 1071
            ..:||.     .||:||:|.|..|:..::|.:..:|
Frog   932 AGEIPR-----KQALETVRNNIEWVAANKEGIKSWL 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	148/393 (38%)
		M1_APN_2	227..667	CDD:189008	171/447 (38%)
		ERAP1_C	742..1052	CDD:288671	88/328 (27%)
enpep	XP_002934295.1	M1_APN-Q_like	107..549	CDD:341064	169/443 (38%)
enpep	XP_002934295.1	ERAP1_C	627..946	CDD:378732	90/332 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920