DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and anpep

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	XP_031755081.1	Gene:	anpep / 100492262	XenbaseID:	XB-GENE-981369	Length:	977	Species:	Xenopus tropicalis

Alignment Length:	924	Identity:	292/924 - (31%)
Similarity:	452/924 - (48%)	Gaps:	102/924 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RLPTNVVPRHYELLLQPNLKE-----FTFTGKTVVQVNVKEPTTQITLN---------------- 261
            |||..:.|.||::.|||.|.:     :.|.||:.......:.|..|.::
Frog    84 RLPKTLSPVHYDVELQPFLVKNADGLYVFRGKSTAFFICNDATDLIIIHSNKLNHTKFNSFDAKL 148

  Fly   262 ---ALDIVLDSVELHFECSKLKPEKIVYSAENETATLEFAQEIPAETQGVLHMSFTGELNDKMKG 323
               |.|:.|.|.  .|:  |.|...:|.:|.|         .:|.:..| |:..|.|||.|.:.|
Frog   149 QDGATDVALKST--FFQ--KDKQFLVVQAAAN---------LVPGKQYG-LYTEFVGELADDLAG 199

  Fly   324 FYRSKYFGPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDS 388
            ||||:|. .:|..:....||.:|.|||:.|||:||||:||||:|||...:...|:|||..|...:
Frog   200 FYRSEYL-EDGVTKIIATTQMQAPDARKAFPCFDEPAMKATFNITLKYRQPYKAMSNMREIDRST 263

  Fly   389 L-PDGLRRV--RFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVL-VRVFTPVGKRE------QGTF 443
            : .||.:..  :||:||.||:||||.:|.|::.|....:..|. |:::   |:::      ||.:
Frog   264 VTEDGQQWTVSKFDKTPKMSSYLVAFIVSEFEAVGDPGNATVTGVQIW---GRKKAIQDENQGEY 325

  Fly   444 ALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQS 508
            ||.|...:|.::.:|:...|||||.|.:|:.||||||||||||||||||.:|.|.:.:|:..|:.
Frog   326 ALSVTKPILDFFAEYYRTPYPLPKSDQVALPDFSAGAMENWGLVTYRETALLFDDQVSSIGNKER 390

  Fly   509 IALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALEL 573
            :...:.||:||||||||||:.||..||||||:||:||:|......|.::|....|.:...|.:.:
Frog   391 VVTVIAHELAHQWFGNLVTIRWWNDLWLNEGFASYVEYLGADKAEPNWNIKDLIVLNDVHRVMAV 455

  Fly   574 DSLKNSHPI---EVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGN 635
            |:|.:|||:   |..|..||||..:||.|:|:|||||||||.:::.|..|..|:..||...:|.|
Frog   456 DALASSHPLTSREDEVNSPSEISALFDSIAYSKGASVIRMLSEFLTEPLFVDGLASYLKGFEYSN 520

  Fly   636 TCTEDLWAALQEASSKN--------VSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTA 692
            |...|||..||.|.:..        :.|:|.:|....|||||.:::......|:...|.......
Frog   521 TVYSDLWTHLQWAVNNQTAVKLPLPIKDIMDTWVLQMGFPVVKIDTATGVVTQKHFLLDPDSVVT 585

  Fly   693 DGSQADENCLWVVPISVSTSKNPTGIAKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYS 757
            ..|..|..  |.||||...|.....|    .|...|..|....:..:||:.:|....||||..|.
Frog   586 RPSPFDYK--WKVPISYKISSKEDNI----WLQNESETVEDFKITGNDWLLVNLNVTGYYRVNYD 644

  Fly   758 ----QEMLEQLMPAVEKMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAI 818
                ..:|.||.  .....:|.::|..:|||.|.:.:|...:|...|........:..|..|.|.
Frog   645 DNNWSRLLNQLQ--TSHQAIPVINRAQIIDDAFNLARAKQITTIQALDTTKYISADREYMPWQAA 707

  Fly   819 TNSLTNLHILISHTDLMEDFHRFGRNLYEPVAYRLGWEPRDGENH----LDTLLRSLVLTRLVSF 879
            .:.|:....:...|::.....::.:....|:......|..:..|.    .|.......|:...|:
Frog   708 LSGLSYFTQMFDRTEVFGPMKKYMKMQVNPLFEYFKQETGNWTNRPVSLTDQYCEINTLSTACSY 772

  Fly   880 RSSDTIEEAKIRFRR----------HVNGTELLPADLRTTCYKAVLQDGDEKIFNEMLDLYRATD 934
            ...|.::.|...|.:          |.|        |||..|...:..|.|:.:|.:.|.::.||
Frog   773 DIEDCLKFASELFSQWMATPQQNNIHPN--------LRTNVYCTAVAQGGEQEWNFVWDRFQLTD 829

  Fly   935 LHEEQDRISRALGCCGDLKLLRRVIDFAMS-SEVRAQDSVFVIVAVAINPKGRDMAWEFFKENNK 998
            :.:|||::..||.|..:..:|.|.:::::. :.:|.||:|..|.:|..||.|:.:||:|.:...|
Frog   830 IAQEQDKLRAALACSKEPWILNRFLEYSLDPTMIRRQDAVSTISSVVNNPIGQSLAWDFVRAKWK 894

  Fly   999 QLLERY-QGGFLLSRLIKYLIENFASEERAKEVEEFLQVNQIPG---CERTVSQAVETIRLNAAW 1059
            .|...: :..|....||:.:...|::|...:::.:|...||.||   ..:.:.||:|..:.|..|
Frog   895 TLYSMFGESSFSFGNLIERVTRRFSTEFELQQLLQFKADNQNPGFGTASQALEQAIEKTKANINW 959

  Fly  1060 LQRDREQLAIFLRD 1073
            :.:::..:..:..|
Frog   960 VNQNKAAVKKWFED 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	163/422 (39%)
		M1_APN_2	227..667	CDD:189008	186/484 (38%)
		ERAP1_C	742..1052	CDD:288671	78/332 (23%)
anpep	XP_031755081.1	M1_APN-Q_like	92..555	CDD:341064	185/480 (39%)
anpep	XP_031755081.1	ERAP1_C	628..955	CDD:403137	80/336 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010