DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cue and LRP8

DIOPT Version :9

Sequence 1:NP_612113.2 Gene:cue / 38174 FlyBaseID:FBgn0011204 Length:644 Species:Drosophila melanogaster
Sequence 2:XP_005271230.1 Gene:LRP8 / 7804 HGNCID:6700 Length:976 Species:Homo sapiens


Alignment Length:662 Identity:130/662 - (19%)
Similarity:228/662 - (34%) Gaps:237/662 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 ALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSD 127
            ||..:.:...||:.||.:|  .|:|...|. |::...::.:......|..|||.|.::.:::|:|
Human   467 ALDVEVATNRIYWCDLSYR--KIYSAYMDK-ASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD 528

  Fly   128 TEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRT 192
            :..:.|..|.:.|.....:   .|.....|..:|||..|..:||::.. ....:|:..|:|.:|.
Human   529 SGNKTISVATVDGGRRRTL---FSRNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGLNGVDRQ 589

  Fly   193 VIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLK--DKHHEPLNLAVTN 255
            .::|.||:.|.||.:|.||.||:|:|.......|::.|   |.:|:.::.  |....|..:||..
Human   590 TLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFS---GGNRKTLISSTDFLSHPFGIAVFE 651

  Fly   256 DAIYWTDRTTRAVWSHPKVPVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARG 320
            |.::|||....|::|..::..::::                                        
Human   652 DKVFWTDLENEAIFSANRLNGLEIS---------------------------------------- 676

  Fly   321 IVARTGFYQRLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATDL 385
            |:|     :.|...|                                                |:
Human   677 ILA-----ENLNNPH------------------------------------------------DI 688

  Fly   386 CICPTGFKGSRCEIRECHNYCVHGTCQMSELAYPKCYCQPGFKGERCELSV-----CSGLCLNGG 445
            .|                         ..||..|:.       .:.|||||     |..|||   
Human   689 VI-------------------------FHELKQPRA-------PDACELSVQPNGGCEYLCL--- 718

  Fly   446 HCRVSKDENEAP--SCECPAKF----GGARCEQ--NSTEICSLFCRLLKHEPEMYVPFGCHSICE 502
              ...:..:.:|  :|.||...    ...||.:  .||...:|...:.:..|......|. ::..
Human   719 --PAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGT-TVHR 780

  Fly   503 ELAQDNST-----------NIAIPQYQHLE-VCLTPRVWTS--------------SVIIILVVGI 541
            ...|::||           ::::|:...:. ..|:|.  ||              |.:...|:||
Human   781 STYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPA--TSNHSQHYANEDSKMGSTVTAAVIGI 843

  Fly   542 VSSLLLVAVIVQG---IRRLYKPK--------RPRIRKTFVVRKQ-----ARTNSAGDT-PLT-- 587
            :..::::|::...   |.|.:|.|        .|..|||.....:     .||...|.. |..  
Human   844 IVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAIS 908

  Fly   588 --NRPLATEQCEITIENCCNMNICET-------PCF--------DPK-----LVEQTLSKSSCKE 630
              :|||..|.|           :.||       |..        :|:     |.:..||:....:
Human   909 SFDRPLWAEPC-----------LGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVK 962

  Fly   631 DKKILIHNMEDD 642
            .|::.: ::|||
Human   963 SKRVAL-SLEDD 973

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cueNP_612113.2 LY 101..141 CDD:214531 9/39 (23%)
Ldl_recept_b 167..208 CDD:278487 12/40 (30%)
LY 193..237 CDD:214531 16/43 (37%)
LRP8XP_005271230.1 LDLa 47..81 CDD:238060
LDLa 85..117 CDD:197566
LDLa 127..163 CDD:238060
LDLa 206..240 CDD:197566
Ldl_recept_a 262..294 CDD:278486
Ldl_recept_a 298..333 CDD:278486
FXa_inhibition 353..387 CDD:291342
EGF_CA 389..419 CDD:214542
LY 458..493 CDD:214531 9/27 (33%)
LY 502..544 CDD:214531 10/41 (24%)
Ldl_recept_b 565..605 CDD:278487 12/40 (30%)
LY 589..631 CDD:214531 16/44 (36%)
Ldl_recept_b 652..691 CDD:278487 12/156 (8%)
FXa_inhibition 710..747 CDD:291342 8/41 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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