Protein Alignment cue and VLDLR

DIOPT Version :9

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_003374.3
• Gene: VLDLR / 7436
• HGNCID: 12698
• Length: 873
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 96/506 - (18%)
• Similarity: 170/506 - (33%)
• Gaps: 181/506 - (35%)

  Fly    63 ALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSD 127
            ||..|.:.:.:::.||..:  :|||...|.....||  :.|....|.:  .:|.|.:...::|:|
Human   473 ALDADIAAQKLFWADLSQK--AIFSASIDDKVGRHV--KMIDNVYNPA--AIAVDWVYKTIYWTD 531

  Fly   128 TEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPT-VERINLDGSNR 191
            ...:.|..|.:.|:....:   .:::...|..:|||.....:||  |:...|. :|:..::|.:|
Human   532 AASKTISVATLDGTKRKFL---FNSDLREPASIAVDPLSGFVYW--SDWGEPAKIEKAGMNGFDR 591

  Fly   192 TVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHH--EPLNLAVT 254
            ..:::::|..|.||.:|.:..||:|:|....:..||:   |:|.||::|||....  .||.|.:.
Human   592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD---LNGQDRRIVLKSLEFLAHPLALTIF 653

  Fly   255 NDAIYWTDRTTRAVWSHPKVPVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEAR 319
            .|.:||.|....||:...|                      |...|       |..:.|...:|:
Human   654 EDRVYWIDGENEAVYGANK----------------------FTGSE-------LATLVNNLNDAQ 689

  Fly   320 GIVARTGFYQRLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATD 384
            .|:.    |..|
Human   690 DIIV----YHEL----------------------------------------------------- 697

  Fly   385 LCICPTGFKGSRCEIRECHNYCVHGTCQMSELAYPKCYCQPGFKGERCELSVCSGLCLNGGHCRV 449
              :.|:|                            |.:|:...:...||.     |||.....
Human   698 --VQPSG----------------------------KNWCEEDMENGGCEY-----LCLPAPQI-- 725

  Fly   450 SKDENEAPSCECPAKF----GGARCEQNSTEICSLFCRLLKHEPEMYVPFGCHSICEELAQDNST 510
             .|.:...:|.||:.:    .|..|:..:|.:                      ...|....|:|
Human   726 -NDHSPKYTCSCPSGYNVEENGRDCQSTATTV----------------------TYSETKDTNTT 767

  Fly   511 NIA-----IPQYQHL-----EVCLTPR----VWTSSVIIILVVGIVSSLLL 547
            .|:     :|...::     ||.:.|:    .|....:::||:..|...|:
Human   768 EISATSGLVPGGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLM 818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	8/39 (21%)
		Ldl_recept_b	167..208	CDD:278487	11/41 (27%)
		LY	193..237	CDD:214531	13/43 (30%)
VLDLR	NP_003374.3	LDLa	33..67	CDD:238060
		LDLa	71..103	CDD:197566
		Ldl_recept_a	111..149	CDD:278486
		LDLa	154..188	CDD:238060
		Ldl_recept_a	192..224	CDD:278486
		Ldl_recept_a	237..273	CDD:278486
		Ldl_recept_a	276..312	CDD:278486
		Ldl_recept_a	320..350	CDD:278486
		FXa_inhibition	360..394	CDD:291342
		EGF_CA	396..426	CDD:214542
		Ldl_recept_b	481..521	CDD:278487	11/45 (24%)
		LY	505..547	CDD:214531	11/45 (24%)
		Ldl_recept_b	568..608	CDD:278487	11/41 (27%)
		LY	592..634	CDD:214531	13/44 (30%)
		Ldl_recept_b	655..694	CDD:278487	13/71 (18%)
		FXa_inhibition	706..749	CDD:291342	11/50 (22%)
		Mucin	<751..813	CDD:250634	12/83 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810