Protein Alignment cue and SORL1

DIOPT Version :10

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_003096.2
• Gene: SORL1 / 6653
• HGNCID: 11185
• Length: 2214
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 121/550 - (22%)
• Similarity: 193/550 - (35%)
• Gaps: 175/550 - (31%)

  Fly    63 ALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSD 127
            ||.||.....:|::||     ::..::| |.......::.|..:|.|:|..||::||:..|:|.|
Human   792 ALDFDYEHNCLYWSDL-----ALDVIQR-LCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVD 850

  Fly   128 TEQRKI--------FFAPIHGSAT---PQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTV 181
            ...:||        |...|..|:.   |:.||.:..||             .::||:.....|.:
Human   851 AGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEG-------------VMFWTDWGDLKPGI 902

  Fly   182 ERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHH 246
            .|.|:|||....::|.::..|.||.||  ...::|.|   .....:|.....|..|.|:|.:..|
Human   903 YRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTD---AYLECIERITFSGQQRSVILDNLPH 962

  Fly   247 EPLNLAVTNDAIYWTDRTTRAVWSHPKVPVIKVTTTSKPDEE----DSTDSTDFK---------- 297
             |..:||..:.|||.|      ||  ::.:.:.:..|....|    ..|...|.|
Human   963 -PYAIAVFKNEIYWDD------WS--QLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGS 1018

  Fly   298 ---DPEPVAEDCPLVRV--ANLSEEARGIVARTGFYQRLQKDHHC----ASIVRKVKERVDEQSR 353
               .|.|    |.|:.:  ||.|...|                 |    :|.|....:.:.:..:
Human  1019 NACVPRP----CSLLCLPKANNSRSCR-----------------CPEDVSSSVLPSGDLMCDCPQ 1062

  Fly   354 KFEIRSLLDQKIKVLEDERCMNDGEYRAATDLCI--------------------CPTGFKGSRCE 398
            .:::::    ...|.::..|:.: :||.:...||                    |||    :.|:
Human  1063 GYQLKN----NTCVKQENTCLRN-QYRCSNGNCINSIWWCDFDNDCGDMSDERNCPT----TICD 1118

  Fly   399 IRECHNYCVHGTCQMSELAYPKC----YCQPGFKGERCELSVC--------SGLCLNG------- 444
            :.........|||  ..|:| ||    .|........||:..|        ||:|:..
Human  1119 LDTQFRCQESGTC--IPLSY-KCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGD 1180

  Fly   445 GHCRVSKDEN---------EAPSCEC------PAKF---GGARCEQNSTEICSLFCRLLKHEPEM 491
            ..||...||.         ||.:.:|      |.::   |...|:..|.|
Human  1181 NDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDE--------------- 1230

  Fly   492 YVPFGCHSICEELAQDNSTNIAIPQYQHLE 521
             .|..|...|......|.|  .||..:|.:
Human  1231 -DPVNCEKKCNGFRCPNGT--CIPSSKHCD 1257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	TerD_like	48..>85	CDD:473128	7/21 (33%)
		YvrE	<73..>164	CDD:442613	26/101 (26%)
		LY	101..141	CDD:214531	15/47 (32%)
		Ldl_recept_b	167..208	CDD:459654	12/40 (30%)
		LY	193..237	CDD:214531	10/43 (23%)
SORL1	NP_003096.2	Cell attachment site. /evidence=ECO:0000255	63..65
		VPS10	124..753	CDD:214740
		BNR 1	136..147
		BNR 2	232..243
		BNR 3	441..452
		BNR 4	521..532
		BNR 5	562..573
		LY	780..821	CDD:214531	9/34 (26%)
		LDL-receptor class B 1	800..843		12/48 (25%)
		LY	824..866	CDD:214531	13/41 (32%)
		LDL-receptor class B 2	844..887		11/42 (26%)
		LY	868..910	CDD:214531	13/54 (24%)
		LDL-receptor class B 3	888..932		15/58 (26%)
		Ldl_recept_b	890..929	CDD:459654	12/38 (32%)
		LY	913..953	CDD:214531	10/44 (23%)
		LDL-receptor class B 4	933..970		11/40 (28%)
		LY	953..993	CDD:214531	14/48 (29%)
		LDL-receptor class B 5	971..1013		11/49 (22%)
		LDLa	1078..1112	CDD:238060	5/34 (15%)
		LDLa	1120..1153	CDD:238060	8/35 (23%)
		Ldl_recept_a	1157..1192	CDD:395011	8/34 (24%)
		LDLa	1198..1230	CDD:197566	7/31 (23%)
		LDLa	1240..1271	CDD:238060	5/19 (26%)
		LDLa	1281..1308	CDD:197566
		LDLa	1325..1359	CDD:238060
		LDLa	1373..1403	CDD:238060
		LDLa	1419..1453	CDD:238060
		LDLa	1471..1506	CDD:238060
		LDLa	1513..1546	CDD:197566
		FN3	1557..>1628	CDD:238020
		FN3	1651..1742	CDD:238020
		FN3	1703..>2099	CDD:442628
		FN3	1934..2021	CDD:238020
		Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000305|PubMed:16531402	2161..2164
		Endocytosis signal. /evidence=ECO:0000255	2172..2177
		Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000269|PubMed:17646382	2190..2214
		Required for interaction with GGA1 and GGA2. /evidence=ECO:0000269|PubMed:11821067	2201..2214
		DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000269|PubMed:20015111	2208..2212