DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cue and ldlrad3

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001124079.1	Gene:	ldlrad3 / 570705	ZFINID:	ZDB-GENE-030131-1533	Length:	314	Species:	Danio rerio

Alignment Length:	214	Identity:	48/214 - (22%)
Similarity:	76/214 - (35%)	Gaps:	72/214 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 CICPTGFKGSRCEIRECHNYCVHGTCQMSELAYPKCYCQPGFKG-----ERCELSVCSGLCLNGG 445
            |..|..|   .|...||  ....|.|.    .||.|..:...:|     .:|..:..|  |.||.
Zfish    27 CSAPGSF---MCADGEC--VPAAGQCD----GYPDCADRSDERGCLKLKSKCASTFFS--CANGV 80

  Fly   446 HCRVSKDENEAPSC----ECPAKFGGARCEQNSTEICS---LFCRLLKHEPEMYVPFGCHS---- 499
            ||.:.:.:     |    :||        :.:..:.|:   |.|..|:        |.|.:
Zfish    81 HCIIGRFQ-----CNGFRDCP--------DGSDEDNCTAHPLLCSSLR--------FHCANGRCV 124

  Fly   500 ----IC--EELAQDNS------TNIAIPQYQ--------HLEVCLTPRVWTSSVIIILVVGIVSS 544
                :|  ::..||||      |....|::.        .....:|..|..|::|.:|||    :
Zfish   125 DRSFLCNGQDNCQDNSDEENCLTTAESPEHMLGTLDYRLRYYPSITYAVIGSAIIFVLVV----A 185

  Fly   545 LLLVAVIVQGIRRLYKPKR 563
            ||.:.:..|..|.:..|:|
Zfish   186 LLALVLHHQRKRSVLLPQR 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531
		Ldl_recept_b	167..208	CDD:278487
		LY	193..237	CDD:214531
ldlrad3	NP_001124079.1	LDLa	30..62	CDD:238060	10/40 (25%)
		LDLa	69..104	CDD:238060	10/49 (20%)
		LDLa	111..145	CDD:238060	9/41 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900