DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cue and lrp1ba

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_021325253.1	Gene:	lrp1ba / 565136	ZFINID:	ZDB-GENE-050208-608	Length:	4654	Species:	Danio rerio

Alignment Length:	499	Identity:	125/499 - (25%)
Similarity:	193/499 - (38%)	Gaps:	128/499 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 IYFNDLKHR------NGSI---FSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSDT 128
            :::.||:.|      :|.|   |...||:.|                      |.:..||:|:|.
Zfish  3958 MFYKDLQDRSPDTTNSGVICPDFRRPRDISA----------------------DWVTGNLYWTDH 4000

  Fly   129 EQ-----------RKIFFA----PIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTH 178
            .:           |::.::    .:.|....:::.|:.   |.|..:.|:..|..:|||... .|
Zfish  4001 SRMHWFSYYTAHWRRLRYSINVGQLGGPNCTRLITDID---GEPFAITVNPIRGMVYWTVIG-DH 4061

  Fly   179 PTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKD 243
            ..:|...:|||.|.|:|:.|:..|.|:.:|..:.||:|.|   .....:.|.:.||||..|.:..
Zfish  4062 SHIEEAAMDGSMRRVLITRNLRRPTGLAIDYYNQRLYWAD---SELSQIGSVRFDGSDSLVAISS 4123

  Fly   244 KH--HEPLNLAVTNDAIYWTD--RTTRAVWSHPKVPVIKVTTTSKPDEEDSTDSTDF---KDPE- 300
            :|  .:|..:.:..|.||...  .....|..:.|:|..:::.    ..|.|:....|   |..|
Zfish  4124 RHGISQPFRIDLFEDYIYGVSMKHDIFRVHKYGKLPAERLSL----GVERSSSVLVFHRYKQQEV 4184

  Fly   301 --PVAE-DCPLVRVANLS------EEARGIVARTGFYQRLQKDHHCASIVRKVKERVDEQSRKFE 356
              |.|: .|..:.:.|.|      .|.:.::.||.....:..|     :.|...|
Zfish  4185 SNPCAQMSCTFLCLLNPSGARCVCPEGKILLNRTCTDTNISGD-----LCRPACE---------- 4234

  Fly   357 IRSLLDQKIKVLEDERCMND--GEYRAATDLCICPTGFKGSRCEIRECHNYCVH-GTCQMSELAY 418
                        ...||:.:  ||.|     |.|...:.|.||||..|.::|:: |||..|.|..
Zfish  4235 ------------NGGRCITNERGESR-----CFCWPNYSGERCEISHCKDFCLNGGTCTGSPLGK 4282

  Fly   419 PKCYCQPGFKGERCELSVCSGLCLNGGHCRVSKDENEAPSCECPAKFGGARCEQNSTEICSLFCR 483
            ..|.|..||.|..||..:|.|.|||||.|.|:.  ...|.|:|||::.|.||:|:   ||..:|.
Zfish  4283 ATCRCALGFSGSLCEQRLCDGFCLNGGSCDVTL--GNQPVCQCPAEYTGERCQQH---ICHHYCA 4342

  Fly   484 LLKHEPEMYVPFGCHSICEELAQDNSTNIAIPQYQHLEVCLTPR 527
            ..|         ||     .|:.........|.......|.|.|
Zfish  4343 HSK---------GC-----TLSSSGHVECVCPTRYEGSKCETDR 4372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	6/54 (11%)
		Ldl_recept_b	167..208	CDD:278487	14/40 (35%)
		LY	193..237	CDD:214531	14/43 (33%)
lrp1ba	XP_021325253.1	LDLa	30..62	CDD:197566
		LDLa	74..107	CDD:197566
		FXa_inhibition	163..191	CDD:317114
		LY	276..309	CDD:214531
		LY	317..359	CDD:214531
		LY	362..402	CDD:214531
		FXa_inhibition	487..519	CDD:317114
		LY	553..593	CDD:214531
		LY	594..633	CDD:214531
		LY	640..689	CDD:214531
		LY	690..732	CDD:214531
		FXa_inhibition	801..838	CDD:317114
		LDLa	891..924	CDD:238060
		LDLa	974..1007	CDD:238060
		LDLa	1011..1042	CDD:197566
		LDLa	1057..1092	CDD:238060
		LDLa	1104..1135	CDD:238060
		LDLa	1140..1173	CDD:197566
		FXa_inhibition	1180..1216	CDD:317114
		LY	1284..1322	CDD:214531
		LY	1331..1370	CDD:214531
		LY	1375..1418	CDD:214531
		LY	<1430..1463	CDD:214531
		LY	1604..1643	CDD:214531
		LY	1645..1687	CDD:214531
		LY	1689..1728	CDD:214531
		LY	<1739..1770	CDD:214531
		FXa_inhibition	1842..1878	CDD:317114
		NHL	1923..>2095	CDD:302697
		NHL repeat	1923..1956	CDD:271320
		NHL repeat	1961..1996	CDD:271320
		NHL repeat	2002..2040	CDD:271320
		NHL repeat	2043..2084	CDD:271320
		FXa_inhibition	2151..2186	CDD:317114
		LY	2265..2305	CDD:214531
		Ldl_recept_b	2334..2375	CDD:278487
		LY	2359..2401	CDD:214531
		FXa_inhibition	2472..2506	CDD:317114
		LDLa	2518..2547	CDD:238060
		LDLa	2556..2590	CDD:238060
		LDLa	2595..2629	CDD:238060
		LDLa	<2652..2681	CDD:294076
		LDLa	2689..2723	CDD:238060
		LDLa	2727..2758	CDD:238060
		LDLa	2768..2801	CDD:238060
		LDLa	2811..2843	CDD:197566
		LDLa	2852..2884	CDD:197566
		LDLa	2898..2932	CDD:238060
		cEGF	2955..2978	CDD:315355
		EGF_CA	2975..3005	CDD:214542
		LY	3042..3086	CDD:214531
		LY	3088..3125	CDD:214531
		Ldl_recept_b	3149..3189	CDD:278487
		LY	3173..3213	CDD:214531
		FXa_inhibition	3284..3320	CDD:317114
		LDLa	3324..3355	CDD:197566
		LDLa	3364..3398	CDD:238060
		LDLa	3403..3438	CDD:238060
		LDLa	3443..3478	CDD:238060
		LDLa	3483..3517	CDD:238060
		LDLa	3522..3556	CDD:238060
		LDLa	3560..3594	CDD:238060
		LDLa	3608..3642	CDD:238060
		LDLa	3646..3681	CDD:238060
LDLa	3688..3720	CDD:238060
LDLa	3729..3765	CDD:238060
LDLa	3775..3809	CDD:238060
Ldl_recept_b	4051..4091	CDD:278487	14/40 (35%)
LY	4075..4116	CDD:214531	13/43 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910