Protein Alignment cue and lrp1bb

DIOPT Version :10

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_073769005.1
• Gene: lrp1bb / 559293
• ZFINID: ZDB-GENE-070912-401
• Length: 4666
• Species: Danio rerio
• Alignment Length: 776
• Identity: 154/776 - (19%)
• Similarity: 249/776 - (32%)
• Gaps: 306/776 - (39%)

  Fly    73 IYFNDLKHRN------GSI---FSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSD- 127
            :::.|:.:|:      |.|   |...||:.|                      |.:..|::|:|
Zfish  3981 LFYKDILNRSQTKTNVGIICPDFRRPRDVSA----------------------DWVTGNIYWTDH 4023

  Fly   128 -------------TEQR-KIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTH 178
                         |:.| .|....:.|....:::.|::   |.|..:||:..:..:||:... .|
Zfish  4024 SRMHWFSYYTAHWTKLRYSINVGQLKGPNCTRLITDIA---GEPYAIAVNPVKGMMYWSVIG-DH 4084

  Fly   179 PTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKD 243
            ..:|...:|||.|.|::...:..|.|:.:|..|.|::|.|....|..||   :.||||..||:..
Zfish  4085 SHIEESAMDGSMRRVLLDKKLRRPTGLAIDYFSQRVYWADAELSVIGSV---RFDGSDTLVVIDG 4146

  Fly   244 KH--HEPLNLAVTNDAIYWT------------------------DRTTRAVWSHPKVPVIKVTTT 282
            |.  .:|..:.:..|.||.|                        ::||..:.||.    .|....
Zfish  4147 KQGISQPYRIDIFEDHIYGTGLKNEVFRIHKYGKRPIEPLDLGIEKTTNVLISHR----FKQQDV 4207

  Fly   283 SKPDEEDSTDSTDFKDPEPVAEDCP----LVRVANLSEEARGIVARTGFYQRLQKDHHCASIVRK 343
            :.|....:.:.....:|...:..||    ||..:.:.....|.:.|..          |.:
Zfish  4208 ANPCLRMTCEFMCLLNPTGASCTCPEGKTLVNGSCIDPIVSGELCRPA----------CEN---- 4258

  Fly   344 VKERVDEQSRKFEIRSLLDQKIKVLEDERCM--NDGEYRAATDLCICPTGFKGSRCEIRECHNYC 406
                                      ..|||  ..|::|     |.|...|.|.|||:..|.:||
Zfish  4259 --------------------------GGRCMANEKGDWR-----CYCWPNFSGERCEVNHCADYC 4292

  Fly   407 VH-GTCQMSELAYPKCYCQPGFKGERCELSVCSGLCLNGGHCRVSKDENEA-------------- 456
            :: |||..|.|..|.|.|..||.|..||..:|...|||||.|.||......
Zfish  4293 LNGGTCTGSPLGKPTCRCVTGFTGPNCERRICDNHCLNGGTCDVSSGNQPVCRCLAEYTGDRCLY 4357

  Fly   457 --------------------PSCECPAKFGGARCE------------------------------ 471
                                ..|.|||::.|.:|:
Zfish  4358 HICHHHCVNSKACTLSSSGHVECVCPARYEGIKCDVDKCLRCHGAPCIINGDTGDVACNCTSGRI 4422

  Fly   472 QNSTEICSLFC---RLLKHEPEMYVPFGCHSI-------CEELAQDNSTNIAIPQYQHLEVCL-- 524
            .:|.::|..:|   .....:|:..:|| ||..       |:|||     |......|:..:|.
Zfish  4423 ASSCQLCDGYCYNGGTCHLDPDTSLPF-CHCTAGFKNQRCDELA-----NPCDYYCQNEGICTIT 4481

  Fly   525 ---TPRV-----W-----------------TSSVIIILVVGIVSSLLLVAVIVQGIRRLYKPKRP 564
               .||.     |                 |:...|.::|.:|..::|:..:|.|:
Zfish  4482 ALNKPRCKCSANWSGTQCERPAPKSSRSDNTAGGSIAIIVPLVLLVILITTVVTGV--------- 4537

  Fly   565 RIRKTFVVRKQARTNSAGDTPLTNRPLATE-------QCEITIEN-------------------- 602
                 |:.|::.|.......|:||..:..|       ..|:..:|
Zfish  4538 -----FICRRRQRGKRVQRQPITNGGINVEIGNPSYNMYEVDHDNHADAGSLLKPNFTLDPHKGW 4597

  Fly   603 C------CNMNICETP----------CFDPKLVEQTLSKSSCK-------EDKKILIHNME 640
            |      |.:||...|          ..:|...:..|...:|:       |.:::|...:|
Zfish  4598 CVKSSDPCTLNIHTVPKEVIPGQPMNYSNPMYAKMYLDGQNCRKPVINIDERRELLPKKLE 4658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	TerD_like	48..>85	CDD:473128	3/17 (18%)
		YvrE	<73..>164	CDD:442613	21/114 (18%)
		LY	101..141	CDD:214531	7/54 (13%)
		Ldl_recept_b	167..208	CDD:459654	11/40 (28%)
		LY	193..237	CDD:214531	14/43 (33%)
lrp1bb	XP_073769005.1	None