DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cue and lrp8

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_005166314.1	Gene:	lrp8 / 557734	ZFINID:	ZDB-GENE-050506-134	Length:	1008	Species:	Danio rerio

Alignment Length:	211	Identity:	70/211 - (33%)
Similarity:	115/211 - (54%)	Gaps:	14/211 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQ-TIARTGNESVGGLAYDPLNMNLFWS 126
            ||..|.:...:|:.||.||  .|||..  :..||:.:|| |:..|...|..|||.|.::.|::|:
Zfish   475 ALDVDVTTNKMYWCDLYHR--KIFSAY--INKANNSSEQITLIDTALHSPEGLAMDWVHKNIYWT 535

  Fly   127 DTEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNR 191
            |:..:.|..|.:.|... :||:|  .|.|.|..:|||..:..:||::.. ....:|:..::|.:|
Zfish   536 DSGHKTISVANVDGKKR-KVLID--TELGEPRAIAVDPRQGFMYWSDWG-AQAKIEKAGMNGVDR 596

  Fly   192 TVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLK--DKHHEPLNLAVT 254
            .|::|..|:.|.||.:|..|.||:|:|....:..||:   |:|.:|:::|.  |:...|..|.:.
Zfish   597 QVLVSERIEWPNGIALDLSSSRLYWVDSKLHLISSVD---LNGDNRRILLSSMDQLGHPFALTLF 658

  Fly   255 NDAIYWTDRTTRAVWS 270
            .|.:||||....|::|
Zfish   659 EDRVYWTDLEYEAIYS 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	13/40 (33%)
		Ldl_recept_b	167..208	CDD:278487	11/40 (28%)
		LY	193..237	CDD:214531	16/43 (37%)
lrp8	XP_005166314.1	LDLa	66..98	CDD:197566
		Ldl_recept_a	107..144	CDD:278486
		Ldl_recept_a	191..224	CDD:278486
		Ldl_recept_a	240..274	CDD:278486
		Ldl_recept_a	278..313	CDD:278486
		LDLa	322..352	CDD:197566
		FXa_inhibition	362..396	CDD:291342
		EGF_CA	398..428	CDD:214542
		LY	463..504	CDD:214531	11/32 (34%)
		LY	511..552	CDD:214531	13/40 (33%)
		Ldl_recept_b	573..613	CDD:278487	11/40 (28%)
		LY	597..639	CDD:214531	16/44 (36%)
		Ldl_recept_b	660..699	CDD:278487	7/15 (47%)
		FXa_inhibition	718..755	CDD:291342
		IgaA	913..>985	CDD:284503
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810