DRSC/TRiP Functional Genomics Resources

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Protein Alignment cue and LRP1B

DIOPT Version :10

Sequence 1:NP_612113.2 Gene:cue / 38174 FlyBaseID:FBgn0011204 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_061027.2 Gene:LRP1B / 53353 HGNCID:6693 Length:4599 Species:Homo sapiens


Alignment Length:570 Identity:133/570 - (23%)
Similarity:224/570 - (39%) Gaps:146/570 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 LAYDPLNMNLFWSDTEQRKIF---------------FAPIHGSATPQVLVDLSAEGGRPDGVAVD 163
            :|.|.:..|::|:|..:...|               ...::|....::|.:::   |.|..:||:
Human  3974 IAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMA---GEPYAIAVN 4035

  Fly   164 VCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVE 228
            ..|..:|||... .|..:|...:||:.|.:::..|:..|.|:.||..|:|::|.|....:..|| 
Human  4036 PKRGMMYWTVVG-DHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSV- 4098

  Fly   229 SSKLDGSDRQVVLKDKHH--EPLNLAVTNDAIYWTDRTTRAVWSHPKVPVIKVTTTSKPDEEDST 291
              ..|||:..|.:..|..  .|..:.:..|.||         .:.||..|.:|       ::...
Human  4099 --LYDGSNSVVSVSSKQGLLHPHRIDIFEDYIY---------GAGPKNGVFRV-------QKFGH 4145

  Fly   292 DSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQKDHHCASIVRKVKERVDEQSR--- 353
            .|.::              :|...::.:|::. :..|::|...:.|..:..:....::....   
Human  4146 GSVEY--------------LALNIDKTKGVLI-SHRYKQLDLPNPCLDLACEFLCLLNPSGATCV 4195

  Fly   354 ----KFEIR------SLLDQKIKVLEDE--RC-MND-GEYRAATDLCICPTGFKGSRCEIRECHN 404
                |:.|.      ||||...|:..:.  || :|: |:.|     |.|...:.|.|||:..|.|
Human  4196 CPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLR-----CHCWPSYSGERCEVNHCSN 4255

  Fly   405 YCVH-GTCQMSELAYPKCYCQPGFKGERCELSVCSGLCLNGGHCRVSKDENEAPSCECPAKFGGA 468
            ||.: |||..|.|..|.|.|..||.|..|..:||...|.|||.|.|:  ....|.|.|..::.|.
Human  4256 YCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVT--AGNQPYCHCQPEYTGD 4318

  Fly   469 RCEQN-------STEICSL--------FCRLLKHEPEMYVP-----FGCHSICEELAQD---NST 510
            ||:..       ::|.|::        .|......|:..|.     .|.|.|..:.::|   |.|
Human  4319 RCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCT 4383

  Fly   511 NIAI--------------------PQYQHLEVCLTPRVWT-----------------SSVIIILV 538
            |..|                    |: .::.|||....|:                 |:..|.::
Human  4384 NGKIASSCQLCDGYCYNGGTCQLDPE-TNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAII 4447

  Fly   539 VGIVSSLLLVAVIVQGIRRLYKPKRPRIRKTFVVRKQARTNSAGDTPLTN 588
            |.:|..:.|:..:|.|: .|.|.|    |:|..:|:|...|...:..:.|
Human  4448 VPLVLLVTLITTLVIGL-VLCKRK----RRTKTIRRQPIINGGINVEIGN 4492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cueNP_612113.2 TerD_like 48..>85 CDD:473128
YvrE <73..>164 CDD:442613 12/64 (19%)
LY 101..141 CDD:214531 6/41 (15%)
Ldl_recept_b 167..208 CDD:459654 11/40 (28%)
LY 193..237 CDD:214531 14/43 (33%)
LRP1BNP_061027.2 LDLa 76..109 CDD:197566
FXa_inhibition 163..193 CDD:464251
NHL 282..459 CDD:302697
NHL repeat 285..321 CDD:271320
LDL-receptor class B 1 295..337
LY 319..361 CDD:214531
NHL repeat 328..367 CDD:271320
LDL-receptor class B 2 338..381
NHL repeat 371..406 CDD:271320
LDL-receptor class B 3 382..425
NHL repeat 415..445 CDD:271320
FXa_inhibition 475..516 CDD:464251
LY 548..590 CDD:214531
LDL-receptor class B 4 568..610
LY 591..630 CDD:214531
LDL-receptor class B 5 611..656
LY 637..686 CDD:214531
LDL-receptor class B 6 657..706
LY 687..729 CDD:214531
LDL-receptor class B 7 707..750
FXa_inhibition 798..833 CDD:464251
LDLa 886..919 CDD:238060
LDLa 926..958 CDD:197566
LDLa 1006..1038 CDD:238060
LDLa 1053..1088 CDD:238060
LDLa 1097..1131 CDD:238060
LDLa 1136..1169 CDD:197566
FXa_inhibition 1176..1212 CDD:464251
YncE 1282..1506 CDD:442618
LDL-receptor class B 8 1300..1346
LY 1327..1367 CDD:214531
LDL-receptor class B 9 1347..1389
LY 1371..1414 CDD:214531
LDL-receptor class B 10 1390..1436
LDL-receptor class B 11 1437..1480
LDL-receptor class B 12 1481..1522
LDL-receptor class B 13 1618..1660
Ldl_recept_b 1618..1658 CDD:459654
LY 1641..1683 CDD:214531
LDL-receptor class B 14 1661..1704
LDL-receptor class B 15 1705..1744
Ldl_recept_b 1705..1742 CDD:459654
LY <1735..1766 CDD:214531
LDL-receptor class B 16 1745..1787
FXa_inhibition 1838..1874 CDD:464251
Vgb 1921..>2110 CDD:443399
LDL-receptor class B 17 1922..1964
LY 1947..1987 CDD:214531
LDL-receptor class B 28 1965..2007
LDL-receptor class B 19 2008..2051
LY 2033..2075 CDD:214531
LDL-receptor class B 20 2052..2095
FXa_inhibition 2147..2182 CDD:464251
LDL-receptor class B 21 2239..2280
LDL-receptor class B 22 2281..2329
LDL-receptor class B 23 2330..2374
Ldl_recept_b 2330..2372 CDD:459654
LY 2355..2397 CDD:214531
LDL-receptor class B 24 2375..2416
LDL-receptor class B 25 2417..2459
FXa_inhibition 2468..2502 CDD:464251
LDLa 2514..2543 CDD:238060
LDLa 2552..2586 CDD:238060
LDLa 2591..2625 CDD:238060
LDLa 2645..2674 CDD:238060
LDLa 2682..2716 CDD:238060
LDLa 2720..2753 CDD:238060
LDLa 2760..2793 CDD:197566
LDLa 2844..2877 CDD:197566
LDLa 2891..2925 CDD:238060
FXa_inhibition 2937..2966 CDD:464251
EGF_CA 2968..2998 CDD:214542
LY 3035..3079 CDD:214531
LDL-receptor class B 26 3055..3098
LY 3080..3118 CDD:214531
LDL-receptor class B 27 3099..3141
LY 3123..3164 CDD:214531
LDL-receptor class B 28 3142..3185
LY 3167..3206 CDD:214531
LDL-receptor class B 29 3186..3224
LDL-receptor class B 30 3225..3268
FXa_inhibition 3277..3313 CDD:464251
LDLa 3317..3348 CDD:197566
LDLa 3357..3391 CDD:238060
LDLa 3396..3431 CDD:238060
LDLa 3436..3471 CDD:238060
LDLa 3476..3510 CDD:238060
LDLa 3515..3549 CDD:238060
LDLa 3553..3587 CDD:238060
LDLa 3594..3628 CDD:238060
LDLa 3632..3667 CDD:238060
LDLa 3674..3706 CDD:238060
LDLa 3721..3751 CDD:238060
LDLa 3762..3796 CDD:238060
EGF_CA 3844..3878 CDD:214542
LDL-receptor class B 31 3933..3980 2/5 (40%)
LY <3971..>3990 CDD:214531 5/15 (33%)
LDL-receptor class B 32 3981..4038 10/59 (17%)
LDL-receptor class B 33 4039..4082 13/43 (30%)
Ldl_recept_b 4039..4080 CDD:459654 12/41 (29%)
LY 4063..4102 CDD:214531 11/41 (27%)
LDL-receptor class B 34 4083..4127 11/46 (24%)
EGF_CA 4250..4284 CDD:238011 15/33 (45%)
Endocytosis signal. /evidence=ECO:0000255 4492..4495 1/1 (100%)
Endocytosis signal. /evidence=ECO:0000255 4559..4562
Blue background indicates that the domain is not in the aligned region.

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