DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cue and LpR2

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster

Alignment Length:	364	Identity:	87/364 - (23%)
Similarity:	142/364 - (39%)	Gaps:	90/364 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 ELSALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIART----GNE----------S 110
            ::..:..|..|.....|..|......|..:..:|..:.||.|:|.:.    ||:          :
  Fly   619 DIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSVT 683

  Fly   111 VGGLAYDPLNMNLFWSDTEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSN 175
            ..|||.|.:..:::::||.:..|......|| ..:|||..|.:  .|..:|:|.....:||::..
  Fly   684 SDGLAVDWIYNHVYFTDTHKCTIELTNFEGS-MGKVLVKDSLD--IPRSIALDPIEGWMYWSDWG 745

  Fly   176 VTHPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVV 240
            .: |.:||..:||::||.||:.::..|.||.:|.:..||:|:|   |...::.||..|||.|..|
  Fly   746 AS-PRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVD---GKLNTISSSNYDGSQRHQV 806

  Fly   241 LKDKHH--EPLNLAVTNDAIYWTDRTTRAVWSHPKVPVIKVTTTSKPDEEDSTDSTDFKDPEPVA 303
            |....:  .|.::....|.:||||      |.  |..|.|....:..|.|..|.:...:.|
  Fly   807 LYSGEYLRHPFSITTFEDYVYWTD------WD--KQAVFKANKFNGMDVEPVTATHMLEHP---- 859

  Fly   304 EDCPLVRVANLSEEARGIVARTGFYQRLQKDHHCASIVRKVKE------RVDEQSRKFEIRSLLD 362
               .:|.|.:...:..|:             :||.|:......      |::|:|.:..
  Fly   860 ---MVVHVYHPYRQPDGV-------------NHCQSVNGHCSHLCLPAPRINERSPRIS------ 902

  Fly   363 QKIKVLEDERCMNDGEYRAATDLCICPTGFK----GSRC 397
                                   |.||||.|    |..|
  Fly   903 -----------------------CACPTGLKLMPDGLMC 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	11/53 (21%)
		Ldl_recept_b	167..208	CDD:278487	14/40 (35%)
		LY	193..237	CDD:214531	16/43 (37%)
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566
		LDLa	235..267	CDD:197566
		LDLa	277..313	CDD:238060
		LDLa	356..388	CDD:197566
		LDLa	400..432	CDD:197566
		LDLa	442..476	CDD:238060
		LDLa	484..517	CDD:197566
		FXa_inhibition	527..562	CDD:291342
		EGF_CA	564..594	CDD:214542
		LY	675..715	CDD:214531	9/40 (23%)
		LY	717..760	CDD:214531	14/45 (31%)
		LY	763..803	CDD:214531	16/42 (38%)
		FXa_inhibition	877..918	CDD:291342	12/69 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461679
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740