DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cue and crb

DIOPT Version :9

Sequence 1:NP_612113.2 Gene:cue / 38174 FlyBaseID:FBgn0011204 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster


Alignment Length:330 Identity:82/330 - (24%)
Similarity:122/330 - (36%) Gaps:117/330 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   362 DQKIKVLEDERCMNDGEYRAATDL-----CICPTGFKGSRCEIRE---CHNY-CVHG-TCQMSEL 416
            :|.|....|:.|.|.|.   .|||     |.||..:.|.:|::.:   |.|. |.:| |||....
  Fly  1937 EQNIDECADQPCHNGGN---CTDLIASYVCDCPEDYMGPQCDVLKQMTCENEPCRNGSTCQNGFN 1998

  Fly   417 AYP----KCYCQPGFKGERCELSVC-------SGLCLNGG---HCRVS---------KDENEAPS 458
            |..    .|.|.|||:|..|::..|       .||||..|   .|:.|         :|.||..|
  Fly  1999 ASTGNNFTCTCVPGFEGPLCDIPFCEITPCDNGGLCLTTGAVPMCKCSLGYTGRLCEQDINECES 2063

  Fly   459 -----------------CECPAK-FGGARCEQNSTEICSL---FCRLLK---HEPEMY-----VP 494
                             |:|... |.|.||| |..:.|::   :|..|.   ::|..:     .|
  Fly  2064 NPCQNGGQCKDLVGRYECDCQGTGFEGIRCE-NDIDECNMEGDYCGGLGRCFNKPGSFQCICQKP 2127

  Fly   495 FGCHSICEELAQDNSTNI------------AIPQYQHLEVCLTPRVW----------------TS 531
            : |.:.|......|:|::            |.|.|    .|..|..:                ::
  Fly  2128 Y-CGAYCNFTDPCNATDLCSNGGRCVESCGAKPDY----YCECPEGFAGKNCTAPITAKEDGPST 2187

  Fly   532 SVIIILVVGIVSSLLLVAVIVQGIRRLYKPKRPRIRKTFVVRKQARTNSAGDTPLTNRPLATEQC 596
            :.|.|:|:.:|..|||:|..:.|              ||:|..:.:..:.|    |..|.|.|.|
  Fly  2188 TDIAIIVIPVVVVLLLIAGALLG--------------TFLVMARNKRATRG----TYSPSAQEYC 2234

  Fly   597 EITIE 601
            ...:|
  Fly  2235 NPRLE 2239

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cueNP_612113.2 LY 101..141 CDD:214531
Ldl_recept_b 167..208 CDD:278487
LY 193..237 CDD:214531
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011
EGF_CA 425..460 CDD:238011
EGF 466..495 CDD:278437
EGF 605..633 CDD:278437
EGF_CA 716..750 CDD:238011
EGF_CA 753..789 CDD:238011
EGF_CA 792..828 CDD:238011
EGF_CA 830..865 CDD:238011
EGF_CA 868..905 CDD:238011
EGF_CA 907..943 CDD:238011
EGF_CA 1009..1045 CDD:238011
EGF_CA 1047..1082 CDD:238011
Laminin_G_1 1155..1290 CDD:278483
EGF 1316..1346 CDD:278437
Laminin_G_1 1388..1550 CDD:278483
EGF_CA <1593..1622 CDD:238011
Laminin_G_2 1692..1828 CDD:280389
EGF_CA 1901..1937 CDD:238011 82/330 (25%)
EGF_CA 1939..1974 CDD:238011 12/37 (32%)
EGF_CA 2057..2094 CDD:238011 9/36 (25%)
EGF_CA 2096..2133 CDD:238011 6/37 (16%)
EGF_CA 2137..2175 CDD:238011 7/41 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24044
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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