DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cue and LRP6

DIOPT Version :10

Sequence 1:NP_612113.2 Gene:cue / 38174 FlyBaseID:FBgn0011204 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_001401173.1 Gene:LRP6 / 4040 HGNCID:6698 Length:1644 Species:Homo sapiens


Alignment Length:264 Identity:80/264 - (30%)
Similarity:126/264 - (47%) Gaps:39/264 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 VLLLATCLLTPAHGTPLEWDFAVTLRTKIQFMDSSWQTIATAAHE--------FDELSALTFDES 69
            |||.|..||..|:            |..::.:|      ||...|        .::.:|:.|..|
Human    15 VLLRAAPLLLYAN------------RRDLRLVD------ATNGKENATIVVGGLEDAAAVDFVFS 61

  Fly    70 EELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSDTEQRKIF 134
            ..|||::|:...     ::||....... :.|.:..:|..|..|||.|.|...|:|:|:|..:|.
Human    62 HGLIYWSDVSEE-----AIKRTEFNKTE-SVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIE 120

  Fly   135 FAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNI 199
            .:.:.||.. :||  ...|..:|..:|:|.....:|||:.... |.:||..:|||:|.:||:|.|
Human   121 VSNLDGSLR-KVL--FWQELDQPRAIALDPSSGFMYWTDWGEV-PKIERAGMDGSSRFIIINSEI 181

  Fly   200 DMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEPLNLAVTNDAIYWTDRT 264
            ..|.|:.:|....:|:|. |.|..|  :..|.|||::||.|:|.....|..|.:..|.:||||.:
Human   182 YWPNGLTLDYEEQKLYWA-DAKLNF--IHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWS 243

  Fly   265 TRAV 268
            |.::
Human   244 THSI 247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cueNP_612113.2 TerD_like 48..>85 CDD:473128 10/44 (23%)
YvrE <73..>164 CDD:442613 25/90 (28%)
LY 101..141 CDD:214531 13/39 (33%)
Ldl_recept_b 167..208 CDD:459654 16/40 (40%)
LY 193..237 CDD:214531 16/43 (37%)
LRP6NP_001401173.1 YncE 1..204 CDD:442618 63/217 (29%)
Beta-propeller 1 20..275 76/259 (29%)
LY 89..127 CDD:214531 12/37 (32%)
Ldl_recept_b 150..191 CDD:459654 16/41 (39%)
LY 175..216 CDD:214531 16/43 (37%)
LY 217..251 CDD:214531 11/31 (35%)
LDL-receptor class B 5 237..276 5/11 (45%)
FXa_inhibition 286..323 CDD:464251
Beta-propeller 2 328..589
LY 353..393 CDD:214531
LY 397..437 CDD:214531
Ldl_recept_b 458..499 CDD:459654
LY 483..524 CDD:214531
LY 525..558 CDD:214531
FXa_inhibition 592..627 CDD:464251
Beta-propeller 3 631..890
YncE <654..813 CDD:442618
LY 697..739 CDD:214531
LY 827..866 CDD:214531
FXa_inhibition 893..929 CDD:464251
LY 958..998 CDD:214531
YncE <968..1075 CDD:442618
LY 1094..1132 CDD:214531
FXa_inhibition 1238..1274 CDD:464251
LDLa 1280..1316 CDD:238060
LDLa 1319..1353 CDD:238060
LDLa 1357..1391 CDD:238060
PPPSP motif A 1518..1524
PPPSP motif B 1558..1565
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1644
PPPSP motif C 1599..1606
PPPSP motif D 1619..1624
PPPSP motif E 1634..1641
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.