Protein Alignment cue and LRP4

DIOPT Version :10

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_002325.2
• Gene: LRP4 / 4038
• HGNCID: 6696
• Length: 1905
• Species: Homo sapiens
• Alignment Length: 345
• Identity: 87/345 - (25%)
• Similarity: 146/345 - (42%)
• Gaps: 83/345 - (24%)

  Fly    63 ALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSD 127
            ||.|....||::::|:     ::..:.|..:..::|.|  :..||.||.||||.|.::..|:|:|
Human   472 ALDFHHRRELVFWSDV-----TLDRILRANLNGSNVEE--VVSTGLESPGGLAVDWVHDKLYWTD 529

  Fly   128 TEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRT 192
            :...:|..|.:.| |..:||:..:.|  :|..:|:......:|||:...| |.:|..::|||.|.
Human   530 SGTSRIEVANLDG-AHRKVLLWQNLE--KPRAIALHPMEGTIYWTDWGNT-PRIEASSMDGSGRR 590

  Fly   193 VIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEPLNLAVTNDA 257
            :|..:::..|.|:.:|....|::|:|....|   :|.:.||||.|:.|:......|..:.|..|:
Human   591 IIADTHLFWPNGLTIDYAGRRMYWVDAKHHV---IERANLDGSHRKAVISQGLPHPFAITVFEDS 652

  Fly   258 IYWTDRTTRAVWS-------------------------HP-KVPVIK---------VTTTSKPDE 287
            :||||..|:::.|                         || :.|..|         .|....|..
Human   653 LYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSG 717

  Fly   288 EDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQKDHHCASIVRK---VKERVD 349
            ::.|.:            ||                 |||  |....|.||..:.|   ...|:|
Human   718 QNYTCA------------CP-----------------TGF--RKISSHACAQSLDKFLLFARRMD 751

  Fly   350 EQSRKFEIRSLLDQKIKVLE 369
            .:...|:...|.|..|.:.:
Human   752 IRRISFDTEDLSDDVIPLAD 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	TerD_like	48..>85	CDD:473128	6/21 (29%)
		YvrE	<73..>164	CDD:442613	25/90 (28%)
		LY	101..141	CDD:214531	14/39 (36%)
		Ldl_recept_b	167..208	CDD:459654	13/40 (33%)
		LY	193..237	CDD:214531	13/43 (30%)
LRP4	NP_002325.2	LDLa	27..66	CDD:238060
		Ldl_recept_a	70..105	CDD:395011
		LDLa	110..142	CDD:238060
		LDLa	148..182	CDD:238060
		LDLa	231..265	CDD:238060
		LDLa	270..304	CDD:238060
		LDLa	311..343	CDD:197566
		FXa_inhibition	358..393	CDD:464251
		EGF_CA	395..434	CDD:214542
		LY	460..502	CDD:214531	7/34 (21%)
		LDL-receptor class B 1	480..522		15/48 (31%)
		LY	505..545	CDD:214531	16/40 (40%)
		LDL-receptor class B 2	523..565		12/44 (27%)
		LDL-receptor class B 3	566..609		14/43 (33%)
		Ldl_recept_b	566..607	CDD:459654	13/41 (32%)
		LY	590..632	CDD:214531	13/44 (30%)
		LDL-receptor class B 4	610..652		13/44 (30%)
		LY	633..673	CDD:214531	10/39 (26%)
		LDL-receptor class B 5	653..693		7/39 (18%)
		FXa_inhibition	702..>729	CDD:464251	8/57 (14%)
		YncE	749..982	CDD:442618	6/23 (26%)
		LDL-receptor class B 6	785..827
		LY	808..850	CDD:214531
		LDL-receptor class B 7	828..870
		LDL-receptor class B 8	871..914
		Ldl_recept_b	871..912	CDD:459654
		LY	895..937	CDD:214531
		LDL-receptor class B 9	915..956
		LDL-receptor class B 10	957..998
		FXa_inhibition	1006..1043	CDD:464251
		NHL	<1085..1277	CDD:302697
		NHL repeat	1085..1123	CDD:271320
		LDL-receptor class B 11	1093..1135
		NHL repeat	1128..1161	CDD:271320
		LDL-receptor class B 12	1136..1178
		NHL repeat	1166..1203	CDD:271320
		LDL-receptor class B 13	1179..1222
		Ldl_recept_b	1179..1219	CDD:459654
		NHL repeat	1212..1244	CDD:271320
		LDL-receptor class B 14	1223..1263
		NHL repeat	1253..1277	CDD:271320
		LDL-receptor class B 15	1264..1306
		FXa_inhibition	1313..1348	CDD:464251
		Vgb	1332..1583	CDD:443399
		LDL-receptor class B 16	1397..1439
		LDL-receptor class B 17	1440..1482
		LDL-receptor class B 18	1483..1526
		LDL-receptor class B 19	1527..1568
		LDL-receptor class B 20	1569..1610
		FXa_inhibition	1617..1648	CDD:464251
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1659..1686
		Endocytosis signal. /evidence=ECO:0000255	1766..1769
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1852..1905