Protein Alignment cue and LRP1

DIOPT Version :9

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_016874792.1
• Gene: LRP1 / 4035
• HGNCID: 6692
• Length: 4561
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 139/569 - (24%)
• Similarity: 211/569 - (37%)
• Gaps: 153/569 - (26%)

  Fly   113 GLAYDPLNMNLFWSDTEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVT 177
            |:|.|.:..|::|:|:.:..|..|.:.|.....::..:..|   |..:.||..|..:||::.. .
Human  3979 GIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDE---PHAIVVDPLRGTMYWSDWG-N 4039

  Fly   178 HPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLK 242
            ||.:|...:||:.|..::..||..|.|:.||..::||:|.|....|..|:   :|:|:|..|...
Human  4040 HPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSI---RLNGTDPIVAAD 4101

  Fly   243 DKH--HEPLNLAVTNDAIYWTDRTTRAVWSHPKV---PVIKVT-------------------TTS 283
            .|.  ..|.::.|..|.||........|:...|.   |::.:|                   .|:
Human  4102 SKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTN 4166

  Fly   284 KPDEE-----------------------DSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVART 325
            ..|.:                       |:........|.| ..|.|.....||.....|
Human  4167 PCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTP-PPDAPRPGTCNLQCFNGG----- 4225

  Fly   326 GFYQRLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATD---LCI 387
            ..:...::...|....|...::.:           |||..     |.|.|.|...|:..   .|.
Human  4226 SCFLNARRQPKCRCQPRYTGDKCE-----------LDQCW-----EHCRNGGTCAASPSGMPTCR 4274

  Fly   388 CPTGFKGSRCEIRECHNYCV-HGTCQMSELAYPKCYCQPGFKGERCELSVCSGLCLNGGHCRVSK 451
            |||||.|.:|..:.|..||. :.||.:::...|:|.|.|||.|:||:...|||.|.|.|.|:::.
Human  4275 CPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAA 4339

  Fly   452 DENEAPSCECPAKFGGARCEQNSTEIC------------SLFCRLL------------------- 485
            |.:.  .|.|.|.|.|:|||.|....|            .:.|...
Human  4340 DGSR--QCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGG 4402

  Fly   486 ------KHEPEMYVPFGCHSI---CEE--LAQDNSTNIAIPQYQHLEVCLTPRVWTSSVIIILVV 539
                  |..||...|  .|..   |||  .:|....:||                  |::|.|:
Human  4403 SCTMNSKMMPECQCP--PHMTGPRCEEHVFSQQQPGHIA------------------SILIPLL- 4446

  Fly   540 GIVSSLLLVAVIVQGIRRLYKPKRPRIRKTFVVRKQARTNSAGDTPLTN 588
                 |||:.|:|.|:...|| :|.:..|.|  :.|..||.|.:..:.|
Human  4447 -----LLLLLVLVAGVVFWYK-RRVQGAKGF--QHQRMTNGAMNVEIGN 4487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	8/27 (30%)
		Ldl_recept_b	167..208	CDD:278487	12/40 (30%)
		LY	193..237	CDD:214531	14/43 (33%)
LRP1	XP_016874792.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810