DRSC/TRiP Functional Genomics Resources

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Protein Alignment cue and LDLR

DIOPT Version :9

Sequence 1:NP_612113.2 Gene:cue / 38174 FlyBaseID:FBgn0011204 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_000518.1 Gene:LDLR / 3949 HGNCID:6547 Length:860 Species:Homo sapiens


Alignment Length:381 Identity:84/381 - (22%)
Similarity:154/381 - (40%) Gaps:89/381 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 QTIATAAHEF----DELSALTFDESE--------------------ELIYFNDLKHRNGSIFSLK 89
            :.:.:.|:.|    .|:..:|.|.||                    ..||::||..|  .|.|.:
Human   393 KAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQR--MICSTQ 455

  Fly    90 RDLIAANHVAE-QTIARTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIHGSATPQVLVDLSAE 153
            .|  .|:.|:. .|:.....::..|||.|.::.|::|:|:....:..|...|.....:..:   .
Human   456 LD--RAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRE---N 515

  Fly   154 GGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWID 218
            |.:|..:.||.....:|||:.. |...:::..|:|.:...:::.||..|.||.:|.||.||:|:|
Human   516 GSKPRAIVVDPVHGFMYWTDWG-TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVD 579

  Fly   219 DLKGVFFSVESSKLDGSDRQVVLKDKHH--EPLNLAVTNDAIYWTDRTTRAVWSHPKVPVIKVTT 281
               ....|:.|..::|.:|:.:|:|:..  .|.:|||..|.::|||....|::|..::....|..
Human   580 ---SKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNL 641

  Fly   282 TSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQKDHHCASIVRKVKE 346
            .::          :...||      .:|...||: :.||:    .:.:|....:.....:.....
Human   642 LAE----------NLLSPE------DMVLFHNLT-QPRGV----NWCERTTLSNGGCQYLCLPAP 685

  Fly   347 RVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATDLCICPTGFKGSRCEIREC 402
            :::..|.||                             .|.||.|...:| ::|.|
Human   686 QINPHSPKF-----------------------------TCACPDGMLLAR-DMRSC 711

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cueNP_612113.2 LY 101..141 CDD:214531 9/39 (23%)
Ldl_recept_b 167..208 CDD:278487 11/40 (28%)
LY 193..237 CDD:214531 15/43 (35%)
LDLRNP_000518.1 Ldl_recept_a 25..58 CDD:278486
Ldl_recept_a 66..104 CDD:278486
Ldl_recept_a 107..143 CDD:278486
Ldl_recept_a 147..179 CDD:278486
Ldl_recept_a 195..231 CDD:278486
Ldl_recept_a 235..270 CDD:278486
LDLa 278..308 CDD:294076
FXa_inhibition 318..>346 CDD:291342
EGF_CA 354..388 CDD:214542
LDL-receptor class B 1 397..438 7/40 (18%)
LY 419..457 CDD:214531 7/39 (18%)
LDL-receptor class B 2 439..485 15/49 (31%)
Ldl_recept_b 439..482 CDD:278487 14/46 (30%)
LDL-receptor class B 3 486..528 9/44 (20%)
Ldl_recept_b 487..525 CDD:278487 7/40 (18%)
LDL-receptor class B 4 529..572 12/43 (28%)
Ldl_recept_b 529..569 CDD:278487 11/40 (28%)
LY 553..595 CDD:214531 15/44 (34%)
LDL-receptor class B 5 573..615 14/44 (32%)
LDL-receptor class B 6 616..658 10/57 (18%)
Ldl_recept_b 616..655 CDD:278487 10/54 (19%)
FXa_inhibition 671..711 CDD:291342 9/69 (13%)
Clustered O-linked oligosaccharides 721..768
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 734..755
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913 811..860
NPXY motif. /evidence=ECO:0000269|PubMed:22509010 823..828
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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