Protein Alignment cue and LDLR

DIOPT Version :10

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_000518.1
• Gene: LDLR / 3949
• HGNCID: 6547
• Length: 860
• Species: Homo sapiens
• Alignment Length: 381
• Identity: 84/381 - (22%)
• Similarity: 154/381 - (40%)
• Gaps: 89/381 - (23%)

  Fly    49 QTIATAAHEF----DELSALTFDESE--------------------ELIYFNDLKHRNGSIFSLK 89
            :.:.:.|:.|    .|:..:|.|.||                    ..||::||..|  .|.|.:
Human   393 KAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQR--MICSTQ 455

  Fly    90 RDLIAANHVAE-QTIARTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIHGSATPQVLVDLSAE 153
            .|  .|:.|:. .|:.....::..|||.|.::.|::|:|:....:..|...|.....:..:   .
Human   456 LD--RAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRE---N 515

  Fly   154 GGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWID 218
            |.:|..:.||.....:|||:.. |...:::..|:|.:...:::.||..|.||.:|.||.||:|:|
Human   516 GSKPRAIVVDPVHGFMYWTDWG-TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVD 579

  Fly   219 DLKGVFFSVESSKLDGSDRQVVLKDKHH--EPLNLAVTNDAIYWTDRTTRAVWSHPKVPVIKVTT 281
               ....|:.|..::|.:|:.:|:|:..  .|.:|||..|.::|||....|::|..::....|..
Human   580 ---SKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNL 641

  Fly   282 TSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQKDHHCASIVRKVKE 346
            .::          :...||      .:|...||: :.||:    .:.:|....:.....:.....
Human   642 LAE----------NLLSPE------DMVLFHNLT-QPRGV----NWCERTTLSNGGCQYLCLPAP 685

  Fly   347 RVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATDLCICPTGFKGSRCEIREC 402
            :::..|.||                             .|.||.|...:| ::|.|
Human   686 QINPHSPKF-----------------------------TCACPDGMLLAR-DMRSC 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	TerD_like	48..>85	CDD:473128	12/59 (20%)
		YvrE	<73..>164	CDD:442613	23/91 (25%)
		LY	101..141	CDD:214531	9/39 (23%)
		Ldl_recept_b	167..208	CDD:459654	11/40 (28%)
		LY	193..237	CDD:214531	15/43 (35%)
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:395011
		Ldl_recept_a	66..104	CDD:395011
		Ldl_recept_a	107..143	CDD:395011
		Binding to Getah virus E1-E2 spike glycoproteins. /evidence=ECO:0000269|PubMed:38245515	146..233
		Ldl_recept_a	147..179	CDD:395011
		Ldl_recept_a	195..231	CDD:395011
		Ldl_recept_a	235..270	CDD:395011
		Ldl_recept_a	278..308	CDD:395011
		FXa_inhibition	318..>346	CDD:464251
		EGF_CA	354..388	CDD:214542
		LDL-receptor class B 1	397..438		7/40 (18%)
		LY	419..457	CDD:214531	7/39 (18%)
		LDL-receptor class B 2	439..485		15/49 (31%)
		Ldl_recept_b	439..483	CDD:459654	14/47 (30%)
		LDL-receptor class B 3	486..528		9/44 (20%)
		Ldl_recept_b	487..526	CDD:459654	8/41 (20%)
		LDL-receptor class B 4	529..572		12/43 (28%)
		Ldl_recept_b	529..569	CDD:459654	11/40 (28%)
		LY	553..595	CDD:214531	15/44 (34%)
		LDL-receptor class B 5	573..615		14/44 (32%)
		LDL-receptor class B 6	616..658		10/57 (18%)
		Ldl_recept_b	616..656	CDD:459654	10/55 (18%)
		FXa_inhibition	671..711	CDD:464251	9/69 (13%)
		Clustered O-linked oligosaccharides	721..768
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	734..755
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913	811..860
		NPXY motif. /evidence=ECO:0000269|PubMed:22509010	823..828