DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cue and vldlr

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_005155618.1	Gene:	vldlr / 393897	ZFINID:	ZDB-GENE-040426-803	Length:	877	Species:	Danio rerio

Alignment Length:	344	Identity:	78/344 - (22%)
Similarity:	145/344 - (42%)	Gaps:	76/344 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANH--VAEQTIARTGNESVGGLAYDPLNMNLFW 125
            ||..|..:::|::.||..:  :|||...|....:|  |.:..      :...|:|.|.:..|::|
Zfish   469 ALDADFIQQMIFWADLGQK--AIFSTVLDKQDESHKKVIDDV------QMPVGIAVDWIYKNIYW 525

  Fly   126 SDTEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPT-VERINLDGS 189
            ||...:.|..|..:|: ..:||.:...:  .|..:|||.....|||  |:...|. :|:..::|:
Zfish   526 SDLGSKSITVANFNGT-KKKVLFNSGLK--EPASIAVDPLSGFLYW--SDWGEPAKIEKSGMNGN 585

  Fly   190 NRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHH--EPLNLA 252
            :|.|::.::|..|.||.:|.:..||:|:|....:..||:   |:|.:|:.||:...:  .|..|.
Zfish   586 DRQVLVETDIQWPNGITLDLIKGRLYWVDSKLHMLCSVD---LNGDNRRKVLQSPDYLAHPFALT 647

  Fly   253 VTNDAIYWTDRTTRAVWSHPKVPVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEE 317
            |..|.::|||....|::...|.....||..          :::..:|:.:.....|::::.
Zfish   648 VFEDRVFWTDGENEAIYGANKFTGSDVTLL----------ASNLNEPQDIIVYHELIQLSG---- 698

  Fly   318 ARGIVARTGFYQRLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAA 382
                   |.:.....::..| |.:.....::::.|.|:
Zfish   699 -------TNWCNEKMENGGC-SFMCLPAPQINKHSPKY--------------------------- 728

  Fly   383 TDLCICPTG----FKGSRC 397
              .|:||.|    ..|.||
Zfish   729 --TCVCPEGQTLASDGLRC 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	9/39 (23%)
		Ldl_recept_b	167..208	CDD:278487	13/41 (32%)
		LY	193..237	CDD:214531	14/43 (33%)
vldlr	XP_005155618.1	LDLa	29..63	CDD:238060
		LDLa	67..99	CDD:197566
		Ldl_recept_a	107..145	CDD:278486
		Ldl_recept_a	149..184	CDD:278486
		Ldl_recept_a	234..269	CDD:278486
		Ldl_recept_a	272..308	CDD:278486
		LDLa	316..346	CDD:238060
		FXa_inhibition	356..390	CDD:291342
		EGF_CA	392..426	CDD:214542
		NHL	479..>570	CDD:302697	28/103 (27%)
		LY	504..541	CDD:214531	10/42 (24%)
		NHL repeat	511..551	CDD:271320	12/40 (30%)
		Ldl_recept_b	564..604	CDD:278487	13/41 (32%)
		LY	588..630	CDD:214531	14/44 (32%)
		Ldl_recept_b	651..690	CDD:278487	9/48 (19%)
		FXa_inhibition	707..745	CDD:291342	9/67 (13%)
		Mucin	<723..817	CDD:250634	9/52 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810