DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cue and ldlra

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001025454.1	Gene:	ldlra / 387529	ZFINID:	ZDB-GENE-031217-1	Length:	911	Species:	Danio rerio

Alignment Length:	265	Identity:	66/265 - (24%)
Similarity:	115/265 - (43%)	Gaps:	72/265 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QTIATAAHEF----DELSALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNE 109
            :.|.|.|:.|    .|:..:|.|.||.:.....||                |.||
Zfish   389 KAIGTIAYLFFTNRHEVRKMTLDRSEYIRVIPRLK----------------NVVA---------- 427

  Fly   110 SVGGLAYDPLNMN-----LFWSDTEQRKIFFAPIHGSATPQVLVDLSAEGGR-----------PD 158
                     |:||     ::|||...:||:  .|.|:.:.     .:|:|.|           |.
Zfish   428 ---------LDMNIASRDIYWSDLSLKKIY--SIRGAISV-----ATADGSRRKTLFKENLAKPR 476

  Fly   159 GVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGV 223
            .:.||..:..::||:.. |...:|:..|:|.:|:.:::.:|..|.||.:|.|::||:|:|   ..
Zfish   477 AIVVDPIKNFMFWTDWG-TPAKIEKSGLNGVDRSTLVADDIVWPNGITLDLLTERLYWVD---SK 537

  Fly   224 FFSVESSKLDGSDRQVVLKD--KHHEPLNLAVTNDAIYWTDRTTRAVWSHPKV---PVIKVTT-T 282
            ..::.|..:.|..|:.::.|  |...||:|.|..:.::|||.:..|:.|..:|   .:.||.. .
Zfish   538 LHTLSSISVQGDGRRTLIIDQGKLAHPLSLTVFEEKVFWTDVSNNAILSANRVTGGDITKVAEHL 602

  Fly   283 SKPDE 287
            |.|::
Zfish   603 SSPED 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	9/44 (20%)
		Ldl_recept_b	167..208	CDD:278487	11/40 (28%)
		LY	193..237	CDD:214531	12/43 (28%)
ldlra	NP_001025454.1	LDLa	23..55	CDD:197566
		Ldl_recept_a	63..101	CDD:365841
		LDLa	106..140	CDD:238060
		LDLa	144..176	CDD:197566
		Ldl_recept_a	192..227	CDD:365841
		Ldl_recept_a	231..266	CDD:365841
		LDLa	274..304	CDD:238060
		FXa_inhibition	314..348	CDD:373209
		EGF_CA	350..380	CDD:214542
		Ldl_recept_b	437..481	CDD:278487	11/50 (22%)
		Ldl_recept_b	485..525	CDD:278487	11/40 (28%)
		LY	510..551	CDD:214531	12/43 (28%)
		Ldl_recept_b	572..611	CDD:278487	10/36 (28%)
		FXa_inhibition	623..664	CDD:373209
		PHA03247	<666..808	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900