Protein Alignment cue and Lrp8

DIOPT Version :9

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_006238632.1
• Gene: Lrp8 / 362558
• RGDID: 1305729
• Length: 1013
• Species: Rattus norvegicus
• Alignment Length: 599
• Identity: 120/599 - (20%)
• Similarity: 201/599 - (33%)
• Gaps: 211/599 - (35%)

  Fly    63 ALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNE--SVGGLAYDPLNMNLFW 125
            ||..:.....||:.||.:|  .|:|...|..:   :.::.:...|.:  |..|||.|.::.:::|
  Rat   504 ALDVEVDTNRIYWCDLSYR--KIYSAHMDKAS---IPDEQVVLIGEQLHSPEGLAVDWVHKHIYW 563

  Fly   126 SDTEQRKIFFAPIHGSATPQVL-VDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGS 189
            :|:..:.:..|...|.....:. .|||    .|..:|||..|..:||::... ...:|:..|:|:
  Rat   564 TDSGNKTVSVATTDGRRRCTLFNRDLS----EPRAIAVDPLRGFMYWSDWGF-QAKIEKAGLNGA 623

  Fly   190 NRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVL--KDKHHEPLNLA 252
            :|..::|.||:.|.||.:|.||.||:|:|   .....:.|...:|.:|::::  .|....|..:|
  Rat   624 DRQTLVSDNIEWPNGITLDLLSQRLYWVD---SKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVA 685

  Fly   253 VTNDAIYWTDRTTRAVWSHPKVPVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEE 317
            |..|.::|||....|::|..::..::::
  Rat   686 VFEDKVFWTDLENEAIFSANRLNGLEIS------------------------------------- 713

  Fly   318 ARGIVARTGFYQRLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAA 382
               |:|     :.|...|
  Rat   714 ---ILA-----ENLNNPH----------------------------------------------- 723

  Fly   383 TDLCICPTGFKGSRCEIRECHNYCVHGTCQMSELAYPKCYCQPGFKGERCELSV-----CSGLCL 442
             |:.|                         ..||..||.       .:.||||.     |..|||
  Rat   724 -DIVI-------------------------FHELKQPKA-------ADACELSAQPNGGCEYLCL 755

  Fly   443 NGGHCRVSKDENEAP--SCECPAKF----GGARC-----EQNSTEICSLFCRLL----------- 485
                 ...:..:.:|  :|.||...    ...||     ..::|.:.|...|.:
  Rat   756 -----PAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPPSTSTTTLASAMTRTVPATTGAPGTTI 815

  Fly   486 ------KHEPEM-----YVPFGCHSICEELAQDNSTNIAIP-QYQHLEVCLTPRVWTSSVIIILV 538
                  .|..||     .||   ||:....|...|.:...| ...|.:..........|.:...|
  Rat   816 HDSTYQNHSTEMPSQTAAVP---HSVNIPKAHSTSPSTLSPATSNHSQHYGNEGSQMGSTVTAAV 877

  Fly   539 VGIVSSLLLVAVIVQG---IRRLYKPK--------RPRIRKTFVVRKQ-----ARTNSAGDT-PL 586
            :||:..::::|::...   |.|.:|.|        .|..|||....::     .||...|.. |.
  Rat   878 IGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPA 942

  Fly   587 T----NRPLATEQC 596
            .    :|||..|.|
  Rat   943 AISSYDRPLWAEPC 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	9/41 (22%)
		Ldl_recept_b	167..208	CDD:278487	12/40 (30%)
		LY	193..237	CDD:214531	15/43 (35%)
Lrp8	XP_006238632.1	LDLa	44..78	CDD:238060
		LDLa	82..114	CDD:197566
		LDLa	124..160	CDD:238060
		LDLa	203..235	CDD:197566
		LDLa	256..289	CDD:238060
		LDLa	295..329	CDD:238060
		LDLa	333..369	CDD:294076
		FXa_inhibition	390..424	CDD:291342
		EGF_CA	426..456	CDD:214542
		LY	495..530	CDD:214531	9/27 (33%)
		LY	540..581	CDD:214531	10/40 (25%)
		Ldl_recept_b	602..642	CDD:278487	12/40 (30%)
		LY	626..668	CDD:214531	15/44 (34%)
		Ldl_recept_b	689..728	CDD:278487	12/156 (8%)
		FXa_inhibition	747..784	CDD:291342	8/41 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810