Protein Alignment cue and Lrp1

DIOPT Version :10

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_008763615.1
• Gene: Lrp1 / 299858
• RGDID: 1307535
• Length: 4562
• Species: Rattus norvegicus
• Alignment Length: 563
• Identity: 142/563 - (25%)
• Similarity: 208/563 - (36%)
• Gaps: 141/563 - (25%)

  Fly   113 GLAYDPLNMNLFWSDTEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVT 177
            |:|.|.:..|::|:|:.:..|..|.:.|.....::..:..|   |..:.||..|..:||::.. .
  Rat  3980 GIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDE---PHAIVVDPLRGTMYWSDWG-N 4040

  Fly   178 HPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLK 242
            ||.:|...:||:.|..::..||..|.|:.||..::||:|.|....|..|:   :|:|:|..|.:.
  Rat  4041 HPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSI---RLNGTDPIVAVD 4102

  Fly   243 DKH--HEPLNLAVTNDAIYWTDRTTRAVWSHPKV---PVIKVTTTSKPDEEDSTDSTDFKDPEPV 302
            .|.  ..|.::.|..|.||........|:...|.   |:|.: |.......|.......|.|| |
  Rat  4103 SKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLINL-TGGLSHASDVVLYHQHKQPE-V 4165

  Fly   303 AEDC---------------PLVRVANLSEEARGI------------VARTG-----------FYQ 329
            ...|               |:....|......|.            ..|.|           .:.
  Rat  4166 TNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCTLQCFNGGSCFL 4230

  Fly   330 RLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATD---LCICPTG 391
            ..::...|....|...::.:           |||..     |.|.|.|...|:..   .|.||||
  Rat  4231 NARRQPKCRCQPRYTGDKCE-----------LDQCW-----EYCHNGGTCAASPSGMPTCRCPTG 4279

  Fly   392 FKGSRCEIRECHNYCV-HGTCQMSELAYPKCYCQPGFKGERCELSVCSGLCLNGGHCRVSKDENE 455
            |.|.||..:.|..||. :.||.:::...|:|.|.|||.|:||:...|||.|.|.|.|:::.|.:.
  Rat  4280 FTGPRCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGFCENFGTCQMAADGSR 4344

  Fly   456 APSCECPAKFGGARCEQNSTEIC------------SLFCRLL----------------------- 485
              .|.|...|.|.|||.|....|            .:.|...
  Rat  4345 --QCRCTVYFEGTRCEVNKCSRCLQGACVVNKQTGDVTCNCTDGRVAPSCLTCIDHCSNGGSCTM 4407

  Fly   486 --KHEPEMYVPFGCHSI---CEELAQDNSTNIAIPQYQHLEVCLTPRVWTSSVIIILVVGIVSSL 545
              |..||...|  .|..   |||.        .:.|.|       |...||.:|.:|       |
  Rat  4408 NSKMMPECQCP--PHMTGPRCEEQ--------VVSQQQ-------PGHMTSILIPLL-------L 4448

  Fly   546 LLVAVIVQGIRRLYKPKRPRIRKTFVVRKQARTNSAGDTPLTN 588
            ||:.::|.|:...|| :|.|..|.|  :.|..||.|.:..:.|
  Rat  4449 LLLLLLVAGVVFWYK-RRVRGAKGF--QHQRMTNGAMNVEIGN 4488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	TerD_like	48..>85	CDD:473128
		YvrE	<73..>164	CDD:442613	12/50 (24%)
		LY	101..141	CDD:214531	8/27 (30%)
		Ldl_recept_b	167..208	CDD:459654	12/40 (30%)
		LY	193..237	CDD:214531	14/43 (33%)
Lrp1	XP_008763615.1	LDLa	27..60	CDD:197566
		LDLa	72..105	CDD:197566
		FXa_inhibition	120..149	CDD:464251
		FXa_inhibition	159..189	CDD:464251
		LY	276..315	CDD:214531
		LY	317..359	CDD:214531
		LY	362..402	CDD:214531
		FXa_inhibition	487..520	CDD:464251
		LY	552..594	CDD:214531
		LY	595..634	CDD:214531
		LY	641..690	CDD:214531
		LY	<701..734	CDD:214531
		FXa_inhibition	808..843	CDD:464251
		LDLa	854..886	CDD:197566
		LDLa	896..929	CDD:238060
		LDLa	936..968	CDD:197566
		LDLa	979..1012	CDD:238060
		LDLa	1033..1066	CDD:238060
		LDLa	1080..1115	CDD:238060
		LDLa	1122..1158	CDD:238060
		LDLa	1163..1196	CDD:238060
		FXa_inhibition	1203..1239	CDD:464251
		Vgb	1328..>1521	CDD:443399
		LY	1354..1394	CDD:214531
		LY	1398..1441	CDD:214531
		LY	1631..1667	CDD:214531
		LY	1668..1711	CDD:214531
		LY	1715..1752	CDD:214531
		LY	1752..1793	CDD:214531
		FXa_inhibition	1868..1904	CDD:464251
		LY	1934..1974	CDD:214531
		LY	1977..2017	CDD:214531
		LY	2018..2061	CDD:214531
		LY	2063..2105	CDD:214531
		FXa_inhibition	2177..2212	CDD:464251
		LY	2293..2333	CDD:214531
		Ldl_recept_b	2362..2404	CDD:459654
		LY	2388..2429	CDD:214531
		FXa_inhibition	2500..2532	CDD:464251
		LDLa	2545..2575	CDD:238060
		LDLa	2584..2618	CDD:238060
		LDLa	2623..2657	CDD:238060
		LDLa	<2684..2706	CDD:238060
		LDLa	2714..2748	CDD:238060
		LDLa	2752..2783	CDD:197566
		LDLa	2791..2824	CDD:197566
		LDLa	2835..2867	CDD:197566
		LDLa	2875..2908	CDD:197566
		LDLa	2925..2957	CDD:238060
		cEGF	2982..3003	CDD:463661
		EGF_CA	3000..>3029	CDD:214542
		LY	3067..3111	CDD:214531
		LY	3112..3154	CDD:214531
		LY	3156..3198	CDD:214531
		LY	3200..3241	CDD:214531
		LY	3242..3282	CDD:214531
		FXa_inhibition	3312..3348	CDD:464251
		LDLa	3352..3383	CDD:238060
		LDLa	3392..3426	CDD:238060
		LDLa	3431..3466	CDD:238060
		LDLa	3470..3503	CDD:197566
		LDLa	3511..3544	CDD:197566
		LDLa	3554..3588	CDD:238060
		LDLa	3593..3627	CDD:238060
LDLa	3631..3665	CDD:238060
LDLa	3671..3703	CDD:197566
LDLa	3713..3749	CDD:238060
LDLa	3764..3794	CDD:238060
YncE	3880..4082	CDD:442618	31/105 (30%)
LY	3973..4010	CDD:214531	9/29 (31%)
Ldl_recept_b	4031..4072	CDD:459654	13/41 (32%)
LY	4055..4096	CDD:214531	14/43 (33%)