DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cue and LRP12

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_038465.1	Gene:	LRP12 / 29967	HGNCID:	31708	Length:	859	Species:	Homo sapiens

Alignment Length:	541	Identity:	96/541 - (17%)
Similarity:	168/541 - (31%)	Gaps:	198/541 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 EQTIARTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIHGSATPQVL--------VDLSAEGGR 156
            |:..|:..|..... |:.|...|.|...:...|::      :..|:.|        :||.
Human   197 EEICAKEANPPTAA-AFQPCAYNQFQCLSRFTKVY------TCLPESLKCDGNIDCLDLG----- 249

  Fly   157 PDGVAVDV--CRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWIDD 219
             |.:..||  |.:.|.:.......|........|||.|.:|.:.                    |
Human   250 -DEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTG--------------------D 293

  Fly   220 LKGVFFSVESSKLDGS---DRQVV---LKDKHHEPLNLAVTNDAIYWTDRTTRAVWSHPKVPVIK 278
            .:.|.......||||:   |...:   |::..|:.|.:....|             ||  .|:..
Human   294 HRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD-------------SH--APLTV 343

  Fly   279 VTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQKDHHCASIVRK 343
            |:::.:                        :||...:::   :.|..||....|.|..|
Human   344 VSSSGQ------------------------IRVHFCADK---VNAARGFNATYQVDGFC------ 375

  Fly   344 VKERVDEQSRKFEIRSLLDQKIK-------VLEDERCMNDGEYRAATDLCICPTGFKGSRCEIRE 401
                             |..:|.       ..|.:||  ||.:.       ||.|...:.|.:.:
Human   376 -----------------LPWEIPCGGNWGCYTEQQRC--DGYWH-------CPNGRDETNCTMCQ 414

  Fly   402 CHNYCVHGTCQMSELAYPKCYCQPGFKGERCELSVCSGLCLNGGHCRVSKDENEAPSCECPAKFG 466
            ...:    .|..:.:.||        :.:||...         .||....||.....|: |..|
Human   415 KEEF----PCSRNGVCYP--------RSDRCNYQ---------NHCPNGSDEKNCFFCQ-PGNF- 456

  Fly   467 GARCEQNSTEICSLFCRLLKHEPEMYVPFGCHSICEELAQDNSTNIAIPQYQHLEVCLTPRVWTS 531
              .|:.|.....|..|             .....|.:.:.:.:..:.:|          .||.|:
Human   457 --HCKNNRCVFESWVC-------------DSQDDCGDGSDEENCPVIVP----------TRVITA 496

  Fly   532 SVIIILVVGIVSSLLLVAV--------IVQGIRRLYKPKRPRIRKTFVVRKQARTNSAGD----- 583
            :||..|:.|:   ||::|:        :....||.::.:..|: :..::|::| ..|.|.
Human   497 AVIGSLICGL---LLVIALGCTCKLYSLRMFERRSFETQLSRV-EAELLRREA-PPSYGQLIAQG 556

  Fly   584 --TPLTNRPLATEQCEITIEN 602
              .|:.:.|:.:......:||
Human   557 LIPPVEDFPVCSPNQASVLEN 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	7/39 (18%)
		Ldl_recept_b	167..208	CDD:278487	7/40 (18%)
		LY	193..237	CDD:214531	7/46 (15%)
LRP12	NP_038465.1	CUB	47..158	CDD:238001
		LDLa	166..200	CDD:238060	1/2 (50%)
		LDLa	215..254	CDD:238060	8/50 (16%)
		CUB	267..371	CDD:238001	26/165 (16%)
		LDLa	375..410	CDD:238060	11/66 (17%)
		LDLa	413..448	CDD:238060	9/55 (16%)
		LDLa	451..485	CDD:238060	8/50 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..678
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..723
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..823
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900