Protein Alignment cue and Lrp5

DIOPT Version :10

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001424443.1
• Gene: Lrp5 / 293649
• RGDID: 1309329
• Length: 1615
• Species: Rattus norvegicus
• Alignment Length: 272
• Identity: 81/272 - (29%)
• Similarity: 136/272 - (50%)
• Gaps: 26/272 - (9%)

  Fly    11 LLVLLLATCLLTPAHGTPLEWDFAVTLRTKIQFMDSSWQTIAT--AAHEFDELSALTFDESEELI 73
            ||:||...|.|.||..:||   .....|..::.:|:....:.:  .|...::.:|:.|..|:..:
  Rat    16 LLLLLALCCSLVPAAASPL---LLFANRRDVRLVDAGGVKLESTIVASGLEDAAAVDFQFSKGAV 77

  Fly    74 YFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAPI 138
            |:.|:...     ::|:..:.....|.|.|..:|..|..|||.|.:...|:|:|:|..:|..|.:
  Rat    78 YWTDVSEE-----AIKQTYLNQTGAAAQNIVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANL 137

  Fly   139 HGSATPQVLV--DLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDM 201
            :|::. :||.  ||.    :|..:|:|.....:|||:.... |.:||..:|||.|.:|:.|:|..
  Rat   138 NGTSR-KVLFWQDLD----QPRAIALDPAHGYMYWTDWGEA-PRIERAGMDGSTRKIIVDSDIYW 196

  Fly   202 PRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEPLNLAVTNDAIYWTDRTTR 266
            |.|:.:|....:|:|. |.|..|  :..:.||||.||.|::.....|..|.::.|.:||||..||
  Rat   197 PNGLTIDLEEQKLYWA-DAKLSF--IHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTR 258

  Fly   267 AV-----WSHPK 273
            ::     |:..|
  Rat   259 SIHACNKWTGEK 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	TerD_like	48..>85	CDD:473128	6/38 (16%)
		YvrE	<73..>164	CDD:442613	25/92 (27%)
		LY	101..141	CDD:214531	14/39 (36%)
		Ldl_recept_b	167..208	CDD:459654	15/40 (38%)
		LY	193..237	CDD:214531	15/43 (35%)
Lrp5	NP_001424443.1	None