DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cue and LRP10

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_005267567.1	Gene:	LRP10 / 26020	HGNCID:	14553	Length:	721	Species:	Homo sapiens

Alignment Length:	279	Identity:	70/279 - (25%)
Similarity:	96/279 - (34%)	Gaps:	97/279 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 EDERCMNDGEYRAA--TDLCICP-----------TGFKGS--------RCEIRECHNYCVHGTCQ 412
            |.:||  ||.:..|  ||...||           .|..|:        ||..:   .:|..|..:
Human   342 EAQRC--DGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQ---TFCADGADE 401

  Fly   413 MSELAYPKC-YCQPG---FKGERC--ELSVCSGL--CLNGGHCRVSKDENEAPSCECPAKFGGAR 469
            .      :| :||||   .:.|:|  |..||.|.  |.:|      .||.:. |...|.|.
Human   402 R------RCRHCQPGNFRCRDEKCVYETWVCDGQPDCADG------SDEWDC-SYVLPRKV---- 449

  Fly   470 CEQNSTEICSLFCRLLKHEPEMYVPFGC-----------HSICEELAQDNSTNI---AIPQYQHL 520
              ..:..|.||.|.||     :.:..||           :||...|::..:..:   |.|.|..|
Human   450 --ITAAVIGSLVCGLL-----LVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQL 507

  Fly   521 ---------EVCLTPRVWTSSVIIILVVGIVSSLLLVAVIVQGIRRLYKP-----KRPRIRKTFV 571
                     |...|.....:||:     |.:.|||      |.:|:...|     .|.|.|...:
Human   508 IAQGAIPPVEDFPTENPNDNSVL-----GNLRSLL------QILRQDMTPGGGPGARRRQRGRLM 561

  Fly   572 VRKQARTNSAGDTPLTNRP 590
            .|...|....|..|.||.|
Human   562 RRLVRRLRRWGLLPRTNTP 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531
		Ldl_recept_b	167..208	CDD:278487
		LY	193..237	CDD:214531
LRP10	XP_005267567.1	CUB	34..134	CDD:238001
		LDLa	148..182	CDD:238060
		CUB	200..310	CDD:238001
		LDLa	<338..361	CDD:238060	8/20 (40%)
		LDLa	407..441	CDD:238060	14/39 (36%)
		PRK04654	<581..683	CDD:135173	70/279 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900