DRSC/TRiP Functional Genomics Resources

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Protein Alignment cue and Vldlr

DIOPT Version :9

Sequence 1:NP_612113.2 Gene:cue / 38174 FlyBaseID:FBgn0011204 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_037287.2 Gene:Vldlr / 25696 RGDID:3963 Length:873 Species:Rattus norvegicus


Alignment Length:506 Identity:98/506 - (19%)
Similarity:168/506 - (33%) Gaps:181/506 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 ALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSD 127
            ||..|.:.:.:::.||..:  :|||...|.....|.  :.|....|.:  .:|.|.:...::|:|
  Rat   473 ALDADIAAQKLFWADLSQK--AIFSASIDDKVGRHF--KMIDNVYNPA--AIAVDWVYKTIYWTD 531

  Fly   128 TEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPT-VERINLDGSNR 191
            ...:.|..|.:.|:....:   .:::...|..:|||.....:||  |:...|. :|:..::|.:|
  Rat   532 AASKTISVATLDGTKRKFL---FNSDLREPASIAVDPLSGFVYW--SDWGEPAKIEKAGMNGFDR 591

  Fly   192 TVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHH--EPLNLAVT 254
            ..:::.:|..|.||.:|.:..||:|:|....:..||:   |:|.||::|||....  .||.|.:.
  Rat   592 RPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVD---LNGQDRRIVLKSLEFLAHPLALTIF 653

  Fly   255 NDAIYWTDRTTRAVWSHPKVPVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEAR 319
            .|.:||.|....||:...|                      |...|       |..:.|...:|:
  Rat   654 EDRVYWIDGENEAVYGANK----------------------FTGSE-------LATLVNNLNDAQ 689

  Fly   320 GIVARTGFYQRLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATD 384
            .|:    .|..|                                                     
  Rat   690 DII----IYHEL----------------------------------------------------- 697

  Fly   385 LCICPTGFKGSRCEIRECHNYCVHGTCQMSELAYPKCYCQPGFKGERCELSVCSGLCLNGGHCRV 449
              :.|:|                            |.:|:...:...||.     |||.....  
  Rat   698 --VQPSG----------------------------KNWCEEDMENGGCEY-----LCLPAPQI-- 725

  Fly   450 SKDENEAPSCECPAKF----GGARCEQNSTEICSLFCRLLKHEPEMYVPFGCHSICEELAQDNST 510
             .|.:...:|.||..:    .|..|:..||             |..|         .|....|:|
  Rat   726 -NDHSPKYTCSCPNGYNLEENGRECQSTST-------------PVTY---------SETKDVNTT 767

  Fly   511 NI-----AIPQYQHL-----EVCLTPR----VWTSSVIIILVVGIVSSLLL 547
            :|     .:|...::     ||.:.|:    .|....:::||:..|...|:
  Rat   768 DILRTSGLVPGGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLM 818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cueNP_612113.2 LY 101..141 CDD:214531 8/39 (21%)
Ldl_recept_b 167..208 CDD:278487 11/41 (27%)
LY 193..237 CDD:214531 13/43 (30%)
VldlrNP_037287.2 LDLa 33..67 CDD:238060
LDLa 71..103 CDD:197566
Ldl_recept_a 111..149 CDD:395011
Ldl_recept_a 153..188 CDD:395011
LDLa 192..224 CDD:197566
Ldl_recept_a 237..273 CDD:395011
Ldl_recept_a 276..312 CDD:395011
Ldl_recept_a 320..350 CDD:395011
FXa_inhibition 360..394 CDD:405372
EGF_CA 396..426 CDD:214542
LDL-receptor class B 1 439..480 3/6 (50%)
LY 461..499 CDD:214531 8/27 (30%)
LDL-receptor class B 2 481..524 11/48 (23%)
Ldl_recept_b 481..521 CDD:395012 10/45 (22%)
LY 508..547 CDD:214531 9/40 (23%)
LDL-receptor class B 3 525..567 9/44 (20%)
LDL-receptor class B 4 568..611 12/44 (27%)
Ldl_recept_b 568..608 CDD:395012 11/41 (27%)
LY 592..634 CDD:214531 13/44 (30%)
LDL-receptor class B 5 612..654 16/44 (36%)
LDL-receptor class B 6 655..697 14/74 (19%)
Ldl_recept_b 655..694 CDD:395012 13/71 (18%)
FXa_inhibition 706..749 CDD:405372 11/50 (22%)
Clustered O-linked oligosaccharides 751..790 10/60 (17%)
Endocytosis signal. /evidence=ECO:0000255 832..837
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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