Protein Alignment cue and Egf

DIOPT Version :10

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_036974.2
• Gene: Egf / 25313
• RGDID: 2542
• Length: 1132
• Species: Rattus norvegicus
• Alignment Length: 588
• Identity: 137/588 - (23%)
• Similarity: 222/588 - (37%)
• Gaps: 192/588 - (32%)

  Fly    46 SSWQTIATAAH--EFDELSALTFDESEELIYFN--DLKHRN--------------GSIFSLKRDL 92
            :||:......:  :.|..|.........|::.|  |::|.:              |.:|:|..|.
  Rat   458 ASWECDCFPGYDLQLDRKSCAASGPQPFLLFANSQDIRHMHFDGTDYKTLLSRQMGMVFALDYDP 522

  Fly    93 IAANHVAEQT-----------------IARTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIHG 140
            :.:.....||                 :...|.::..|||.|.:...::|:|:.:..|..:.:.|
  Rat   523 VESKIYFAQTALKWIERANLDGSQRERLITEGVDTPEGLAVDWIGRRIYWTDSGKSVIEGSDLSG 587

  Fly   141 SATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGI 205
            . ..|:::..|.  .||.|:||....|:|:||::.:: |.:|..:|.||:||:|.|||:..|.||
  Rat   588 K-HHQIIIKESI--SRPRGIAVHPKARRLFWTDTGMS-PRIESSSLQGSDRTLIASSNLLEPSGI 648

  Fly   206 VVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEPLNLAVTNDAIYWTDRTTRAVWS 270
            .:|.|:|.|:|.|....|   :|.:.||||.|:.:.::....|.:|||..|.::::|      |:
  Rat   649 AIDYLTDTLYWCDTKLSV---IEMADLDGSKRRRLTQNDVGHPFSLAVFEDHVWFSD------WA 704

  Fly   271 HPKVPVIKVTTTS------------KPDEEDSTDSTDFKDP--EPVAEDCPLVR---VANLSEEA 318
            .|.  ||:|...:            ||      .|.....|  :|.|:.| |.|   ..::.:|:
  Rat   705 IPS--VIRVNKRTGQNRVRLRGSMLKP------SSLVVVHPLAKPGADPC-LHRNGGCEHICQES 760

  Fly   319 RG---IVARTGFYQR-------LQKD------------HHCASIVRKVKERVDEQSRKFEIRSLL 361
            .|   .:.|.||.:.       .:||            ...||:....|..|.:..|...  |.|
  Rat   761 LGTAQCLCREGFVKAPDGKMCLTRKDDQILAGDNADLSKEVASLDNSPKAYVPDDDRTES--STL 823

  Fly   362 DQKIKV----LEDE----------RCMNDGEYRAATDLCICPTGFKG------------------ 394
            ..:|.|    .||:          .|:::||  ||  :|.|..||.|
  Rat   824 VAEIMVSGLNYEDDCGPGGCGSHAHCISEGE--AA--VCQCLKGFAGDGNLCSDIDECELGSSDC 884

  Fly   395 ----SRC-----------------------EIREC----HNYCVHGTCQMSELAYPKCYC----- 423
                |||                       ::.||    |....:.||..:|..| .|.|
  Rat   885 PPTSSRCINTEGGYVCQCSEGYEGDGIYCLDVDECQQGSHGCSENATCTNTEGGY-NCTCAGCPS 948

  Fly   424 ----------QPGFKGE------RCELSVC----SGLCLNGGHCRVSKDENEAPSCECPAKFGGA 468
                      .|...|:      |..::.|    .|.|||||.| :..:..:...|.|...:.|.
  Rat   949 APGLPCPDSTSPSLLGKDGCHWVRNSITGCPPSYDGYCLNGGVC-MYVESVDRYVCNCVIGYIGE 1012

  Fly   469 RCE 471
            ||:
  Rat  1013 RCQ 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	TerD_like	48..>85	CDD:473128	8/54 (15%)
		YvrE	<73..>164	CDD:442613	25/123 (20%)
		LY	101..141	CDD:214531	10/56 (18%)
		Ldl_recept_b	167..208	CDD:459654	18/40 (45%)
		LY	193..237	CDD:214531	19/43 (44%)
Egf	NP_036974.2	LDL-receptor class B 1	87..128
		LDL-receptor class B 2	129..170
		LY	152..193	CDD:214531
		LDL-receptor class B 3	171..212
		LDL-receptor class B 4	213..259
		cEGF	339..360	CDD:463661
		FXa_inhibition	361..396	CDD:464251
		FXa_inhibition	409..437	CDD:464251
		FXa_inhibition	440..477	CDD:464251	3/18 (17%)
		LDL-receptor class B 5	484..524		8/39 (21%)
		LY	505..547	CDD:214531	6/41 (15%)
		LDL-receptor class B 6	525..567		7/41 (17%)
		LY	548..590	CDD:214531	9/42 (21%)
		LDL-receptor class B 7	568..610		11/44 (25%)
		LY	591..634	CDD:214531	16/45 (36%)
		LDL-receptor class B 8	611..654		19/43 (44%)
		LY	634..677	CDD:214531	21/45 (47%)
		LDL-receptor class B 9	655..697		15/44 (34%)
		LY	678..719	CDD:214531	11/48 (23%)
		FXa_inhibition	746..781	CDD:464251	8/35 (23%)
		EGF_3	839..871	CDD:463759	10/35 (29%)
		EGF_CA	873..913	CDD:214542	3/39 (8%)
		EGF_CA	915..943	CDD:429571	8/28 (29%)
		PHA03099	<974..>1016	CDD:165381	13/43 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1068..1096