Protein Alignment cue and Ldlrad3

DIOPT Version :10

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_849217.2
• Gene: Ldlrad3 / 241576
• MGIID: 2138856
• Length: 345
• Species: Mus musculus
• Alignment Length: 206
• Identity: 43/206 - (20%)
• Similarity: 64/206 - (31%)
• Gaps: 79/206 - (38%)

  Fly   383 TDLCICPTGFKGSRCEIRECHN-YCVHGTCQMSELAYPKCY--------------CQPGF----K 428
            |:.|..|..|.        |.| .|:.|..|...|  |.|:              |.|.|    .
Mouse    26 TNECNIPGNFM--------CSNGRCIPGAWQCDGL--PDCFDKSDEKECPKAKSKCGPTFFPCAS 80

  Fly   429 GERCELS--VCSGL--CLNGG-----------------HCRVSKDENEAPSCECPAKFGGARCEQ 472
            |..|.:.  .|:|.  |.:|.                 |||.....:::..|:     |...|:.
Mouse    81 GIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCRNGLCIDKSFICD-----GQNNCQD 140

  Fly   473 NSTEICSLFCRLLKHEPEMYVPFGCHSICEELAQDNSTNIAIPQYQHLEV--CLTPRVWTSSVII 535
            ||.|                      ..||...:..|..:.:.....|..  .:|..:..||||.
Mouse   141 NSDE----------------------ESCESSLEPGSGQVFVTSENQLVYYPSITYAIIGSSVIF 183

  Fly   536 ILVVGIVSSLL 546
            :|||.:::.:|
Mouse   184 VLVVALLALVL 194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	TerD_like	48..>85	CDD:473128
		YvrE	<73..>164	CDD:442613
		LY	101..141	CDD:214531
		Ldl_recept_b	167..208	CDD:459654
		LY	193..237	CDD:214531
Ldlrad3	NP_849217.2	LDLa	32..64	CDD:238060	10/41 (24%)
		LDLa	71..106	CDD:238060	9/34 (26%)
		LDLa	113..147	CDD:238060	9/60 (15%)
		Involved in ITCH interaction. /evidence=ECO:0000250|UniProtKB:Q86YD5	256..259
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	270..345
		Involved in ITCH interaction. /evidence=ECO:0000250|UniProtKB:Q86YD5	275..278