DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cue and Lrp12

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_006520965.1	Gene:	Lrp12 / 239393	MGIID:	2443132	Length:	859	Species:	Mus musculus

Alignment Length:	249	Identity:	48/249 - (19%)
Similarity:	87/249 - (34%)	Gaps:	77/249 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 EDERCMNDGEYRAATDLCICPTGFKGSRCEIRECHNYCVHGTCQMSELAYPKCYCQPGFKGERCE 433
            |.:||  ||.:.       ||.|.....|.:.:...:    .|..:.:.||        :.:||.
Mouse   392 EQQRC--DGYWH-------CPNGRDEINCTMCQKEEF----PCSRNGVCYP--------RSDRCN 435

  Fly   434 LSVCSGLCLNGGHCRVSKDENEAPSCECPAKFGGARCEQNSTEICSLFCRLLKHEPEMYVPFGCH 498
            ..         .||....||.....|: |..|   .|:.|.....|..|             ...
Mouse   436 YQ---------NHCPNGSDEKNCFFCQ-PGNF---HCKNNRCVFESWVC-------------DSQ 474

  Fly   499 SICEELAQDNSTNIAIPQYQHLEVCLTPRVWTSSVIIILVVGIVSSLLLVAV--------IVQGI 555
            ..|.:.:.:.:..:.:|          .||.|::||..|:.|:   ||::|:        :....
Mouse   475 DDCGDGSDEENCPVIVP----------TRVITAAVIGSLICGL---LLVIALGCTCKLYSLRMFE 526

  Fly   556 RRLYKPKRPRIRKTFVVRKQARTNSAGD-------TPLTNRPLATEQCEITIEN 602
            ||.::.:..|: :..::|::| ..|.|.       .|:.:.|:.:......:||
Mouse   527 RRSFETQLSRV-EAELLRREA-PPSYGQLIAQGLIPPVEDFPVCSPNQASVLEN 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531
		Ldl_recept_b	167..208	CDD:278487
		LY	193..237	CDD:214531
Lrp12	XP_006520965.1	CUB	47..156	CDD:366096
		LDLa	167..201	CDD:238060
		LDLa	216..255	CDD:238060
		CUB	268..372	CDD:238001
		LDLa	376..411	CDD:238060	8/27 (30%)
		LDLa	414..449	CDD:238060	9/55 (16%)
		LDLa	452..486	CDD:238060	8/50 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900