DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cue and Lrp4

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_766256.3	Gene:	Lrp4 / 228357	MGIID:	2442252	Length:	1905	Species:	Mus musculus

Alignment Length:	345	Identity:	88/345 - (25%)
Similarity:	146/345 - (42%)	Gaps:	83/345 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSD 127
            ||.|....||::::|:     ::..:.|..:..::|.|  :..||.||.||||.|.::..|:|:|
Mouse   472 ALDFHHRRELVFWSDV-----TLDRILRANLNGSNVEE--VVSTGLESPGGLAVDWVHDKLYWTD 529

  Fly   128 TEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRT 192
            :...:|..|.:.| |..:||:..|.|  :|..:|:......:|||:...| |.:|..::|||.|.
Mouse   530 SGTSRIEVANLDG-AHRKVLLWQSLE--KPRAIALHPMEGTIYWTDWGNT-PRIEASSMDGSGRR 590

  Fly   193 VIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEPLNLAVTNDA 257
            :|..:::..|.|:.:|....|::|:|....|   :|.:.||||.|:.|:......|..:.|..|:
Mouse   591 IIADTHLFWPNGLTIDYAGRRMYWVDAKHHV---IERANLDGSHRKAVISQGLPHPFAITVFEDS 652

  Fly   258 IYWTDRTTRAVWS-------------------------HP-KVPVIK---------VTTTSKPDE 287
            :||||..|:::.|                         || :.|..|         .|....|..
Mouse   653 LYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSG 717

  Fly   288 EDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQKDHHCASIVRK---VKERVD 349
            ::.|.:            ||                 |||  |....|.||..:.|   ...|:|
Mouse   718 QNYTCA------------CP-----------------TGF--RKINSHACAQSLDKFLLFARRMD 751

  Fly   350 EQSRKFEIRSLLDQKIKVLE 369
            .:...|:...|.|..|.:.:
Mouse   752 IRRISFDTEDLSDDVIPLAD 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	14/39 (36%)
		Ldl_recept_b	167..208	CDD:278487	13/40 (33%)
		LY	193..237	CDD:214531	13/43 (30%)
Lrp4	NP_766256.3	LDLa	27..66	CDD:238060
		Ldl_recept_a	70..105	CDD:278486
		LDLa	110..142	CDD:238060
		LDLa	148..182	CDD:238060
		LDLa	231..265	CDD:238060
		LDLa	270..304	CDD:238060
		LDLa	311..343	CDD:197566
		FXa_inhibition	358..393	CDD:291342
		EGF_CA	395..434	CDD:214542
		NHL	<471..622	CDD:302697	49/163 (30%)
		NHL repeat	471..507	CDD:271320	9/41 (22%)
		LDL-receptor class B 1	480..522		15/48 (31%)
		LY	505..545	CDD:214531	16/40 (40%)
		NHL repeat	510..550	CDD:271320	16/40 (40%)
		LDL-receptor class B 2	523..565		13/44 (30%)
		NHL repeat	555..589	CDD:271320	11/34 (32%)
		LDL-receptor class B 3	566..609		14/43 (33%)
		LY	590..632	CDD:214531	13/44 (30%)
		NHL repeat	598..622	CDD:271320	7/26 (27%)
		LDL-receptor class B 4	610..652		13/44 (30%)
		LY	633..673	CDD:214531	10/39 (26%)
		LDL-receptor class B 5	653..693		7/39 (18%)
		FXa_inhibition	702..>729	CDD:291342	8/57 (14%)
		LY	766..806	CDD:214531	1/6 (17%)
		LDL-receptor class B 6	785..827
		LY	808..850	CDD:214531
		LDL-receptor class B 7	828..870
		LDL-receptor class B 8	871..914
		Ldl_recept_b	871..911	CDD:278487
		LY	895..937	CDD:214531
		LDL-receptor class B 9	915..956
		LY	938..979	CDD:214531
		LDL-receptor class B 10	957..998
		FXa_inhibition	1006..1043	CDD:291342
		NHL	<1085..1277	CDD:302697
		NHL repeat	1085..1123	CDD:271320
		LDL-receptor class B 11	1093..1135
		NHL repeat	1128..1161	CDD:271320
		LDL-receptor class B 12	1136..1178
		NHL repeat	1166..1203	CDD:271320
		LDL-receptor class B 13	1179..1222
		NHL repeat	1212..1244	CDD:271320
		LDL-receptor class B 14	1223..1263
		NHL repeat	1253..1277	CDD:271320
		LDL-receptor class B 15	1264..1306
		FXa_inhibition	1313..1348	CDD:291342
		LY	1379..1418	CDD:214531
		LDL-receptor class B 16	1397..1439
		LY	1420..1460	CDD:214531
		LDL-receptor class B 17	1440..1482
		LDL-receptor class B 18	1483..1526
		Ldl_recept_b	1483..1523	CDD:278487
		LY	1507..1547	CDD:214531
		LDL-receptor class B 19	1527..1568
		LY	1549..1589	CDD:214531
		LDL-receptor class B 20	1569..1610
		FXa_inhibition	1617..1648	CDD:291342
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1661..1696
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1852..1905
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900