DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cue and Sorl1

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_035566.2	Gene:	Sorl1 / 20660	MGIID:	1202296	Length:	2215	Species:	Mus musculus

Alignment Length:	587	Identity:	126/587 - (21%)
Similarity:	194/587 - (33%)	Gaps:	219/587 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 IATAAHEFDELS------ALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNE 109
            :|:.|.|...||      ||.||.....:|::||     ::.:::| |.......::.|..:|.|
Mouse   774 LASGATEQLPLSGLRAAVALDFDYERNCLYWSDL-----ALDTIQR-LCLNGSTGQEVIINSGLE 832

  Fly   110 SVGGLAYDPLNMNLFWSDTEQRKI--------FFAPIHGSAT---PQVLVDLSAEGGRPDGVAVD 163
            :|..||::||:..|:|.|...:||        |...|..|:.   |:.||.:..||
Mouse   833 TVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEG--------- 888

  Fly   164 VCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVE 228
                .::||:.....|.:.|..:|||....::|.::..|.||.||  |..::|.|   .....:|
Mouse   889 ----VMFWTDWGDLKPGIYRSYMDGSAAYRLVSEDVKWPNGISVD--SQWIYWTD---AYLDCIE 944

  Fly   229 SSKLDGSDRQVVLKDKHHEPLNLAVTNDAIYWTDRTTRAVW-----SHPKVPVIKVTTTSKPDEE 288
            .....|..|.|:|....| |..:||..:.|||.|.:..:::     |..:|.::....|...|.:
Mouse   945 RITFSGQQRSVILDSLPH-PYAIAVFKNEIYWDDWSQLSIFRASKHSRSQVEILASQLTGLMDMK 1008

  Fly   289 ------------------------DSTDSTDFKDPEPVAE----------DCPLVRVANLSEEAR 319
                                    .:.:|...:.||.||.          |||           :
Mouse  1009 VFYKGKNAGSNACVPQPCSLLCLPKANNSKSCRCPEGVASSVLPSGDLMCDCP-----------Q 1062

  Fly   320 GIVARTGFYQRLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATD 384
            |       |||  |::.|                             |.|:..|:.: :||.:..
Mouse  1063 G-------YQR--KNNTC-----------------------------VKEENTCLRN-QYRCSNG 1088

  Fly   385 LCI--------------------CPTGFKGSRCEIRECHNYCVHGTCQMSELAYPKCY------- 422
            .||                    |||....:..:.|          ||.|....|..|
Mouse  1089 NCINSIWWCDFDNDCGDMSDERNCPTTVCDADTQFR----------CQESGTCIPLSYKCDLEDD 1143

  Fly   423 CQPGFKGERCELSVC--------SGLCLNG-------GHCRVSKDEN---------EAPSCEC-- 461
            |........||:..|        ||:|:..       ..||...||.         ||.:.:|
Mouse  1144 CGDNSDESHCEMHQCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCHN 1208

  Fly   462 ----PAKF---GGARCEQNSTEICSLFCRLLKHEPEMYVPFGCHSICEELAQDNSTNIAIPQYQH 519
                |.::   |.|.|:..|.|                .|..|...|......|.|  .||..:|
Mouse  1209 GHCIPQRWACDGDADCQDGSDE----------------DPVSCEKKCNGFHCPNGT--CIPSSKH 1255

  Fly   520 LE 521
            .:
Mouse  1256 CD 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	15/47 (32%)
		Ldl_recept_b	167..208	CDD:278487	11/40 (28%)
		LY	193..237	CDD:214531	11/43 (26%)
Sorl1	NP_035566.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..84
		VPS10	124..753	CDD:214740
		BNR 1	136..147
		BNR 2	232..243
		BNR 3	441..452
		BNR 4	521..532
		BNR 5	562..573
		Sortilin_C	588..753	CDD:292523
		LY	780..821	CDD:214531	12/46 (26%)
		LDL-receptor class B 1	800..843		12/48 (25%)
		LY	824..866	CDD:214531	13/41 (32%)
		LDL-receptor class B 2	844..887		11/42 (26%)
		LY	868..910	CDD:214531	12/54 (22%)
		LDL-receptor class B 3	888..932		15/58 (26%)
		Ldl_recept_b	890..929	CDD:278487	11/38 (29%)
		LY	913..953	CDD:214531	11/44 (25%)
		LDL-receptor class B 4	933..972		11/42 (26%)
		LDL-receptor class B 5	973..1013		8/39 (21%)
		LDLa	1078..1112	CDD:238060	5/34 (15%)
		LDLa	1117..1153	CDD:238060	7/45 (16%)
		Ldl_recept_a	1157..1192	CDD:278486	8/34 (24%)
		Ldl_recept_a	1198..1230	CDD:278486	8/31 (26%)
		LDLa	1240..1271	CDD:238060	5/20 (25%)
		LDLa	1281..1308	CDD:197566
		LDLa	1325..1359	CDD:238060
		LDLa	1373..1403	CDD:238060
		LDLa	1419..1453	CDD:238060
		LDLa	1471..1506	CDD:238060
		LDLa	1514..1549	CDD:238060
		FN3	1557..1630	CDD:238020
		FN3	1651..1742	CDD:238020
		FN3	1752..1831	CDD:238020
		FN3	1935..2022	CDD:238020
		FN3	2026..2113	CDD:238020
		Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000250\|UniProtKB:Q92673	2162..2165
		Endocytosis signal. /evidence=ECO:0000255	2173..2178
		Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000250\|UniProtKB:Q92673	2191..2215
		Required for interaction with GGA1 and GGA2. /evidence=ECO:0000250\|UniProtKB:Q92673	2202..2215
		DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000250\|UniProtKB:Q92673	2209..2213
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900