DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cue and EGF

DIOPT Version :10

Sequence 1:NP_612113.2 Gene:cue / 38174 FlyBaseID:FBgn0011204 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_001954.2 Gene:EGF / 1950 HGNCID:3229 Length:1207 Species:Homo sapiens


Alignment Length:704 Identity:155/704 - (22%)
Similarity:258/704 - (36%) Gaps:199/704 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 SWQTIATAAH--EFDELSALTFDESEELIYFN--DLKHRN--------------GSIFSLKRDLI 93
            ||:......:  :.||.|.........|::.|  |::|.:              |.:::|..|.:
Human   458 SWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPV 522

  Fly    94 AAN----HVAEQTIART-------------GNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIHGS 141
            ...    |.|.:.|.|.             |.:...|||.|.:....:|:|..:..|..:.::|.
Human   523 ENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGK 587

  Fly   142 ATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIV 206
            .:..:..:..::   |.|:||....::|:||::.: :|.:|..:|.|..|.||.||::..|.||.
Human   588 RSKIITKENISQ---PRGIAVHPMAKRLFWTDTGI-NPRIESSSLQGLGRLVIASSDLIWPSGIT 648

  Fly   207 VDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEPLNLAVTNDAIYWTDRTTRAVWSH 271
            :|.|:|:|:|.|..:.|   :|.:.||||.|:.:.::....|..:||..|.::::|      |:.
Human   649 IDFLTDKLYWCDAKQSV---IEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSD------WAM 704

  Fly   272 PKVPVIKVTTTS----------KPDEEDSTDSTDFKDP--EPVAEDCPLVR--VANLSEEARGIV 322
            |.|..:...|..          ||      .|.....|  :|.|:.|....  ..::.::..|..
Human   705 PSVMRVNKRTGKDRVRLQGSMLKP------SSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTA 763

  Fly   323 ---ARTGFYQR------LQKDHHCASIVRKV-------------KERVDEQSRKFEIRSLLDQKI 365
               .|.||.:.      |..|.|......:|             |.||.|.:.. |.:.:|..:|
Human   764 WCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNIT-ESQHMLVAEI 827

  Fly   366 KVLEDE-----------RCMNDGEYRAATDLCICPTGF--KGSRC-EIRECH---NYC--VHGTC 411
            .|.:.:           ||:::||  .||  |.|..||  .|..| :|.||.   ..|  ....|
Human   828 MVSDQDDCAPVGCSMYARCISEGE--DAT--CQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKC 888

  Fly   412 QMSELAYPKCYCQPGFKG--------ERCELSVCS----GLCLN--GGHCRVSKDENEAPSCECP 462
            ..:|..| .|.|..|::|        :.|:|...|    ..|.|  ||:..:.......|...||
Human   889 INTEGGY-VCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICP 952

  Fly   463 AKFGGARCEQ--------NSTEICSL----FCRLLKHEPEMYV----PFGCHSICEELAQDNSTN 511
            .........:        ||...|.|    :|  |.....||:    .:.|:.:...:.:.    
Human   953 DSTPPPHLREDDHHYSVRNSDSECPLSHDGYC--LHDGVCMYIEALDKYACNCVVGYIGER---- 1011

  Fly   512 IAIPQYQHLEVCLTPRVW---------TSSVIIILVVGIVSSLLLVAVIVQGIR--RLYK----- 560
               .||:.|:       |         ....:|::.|.:|..::|:.:.:.|..  |..|     
Human  1012 ---CQYRDLK-------WWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKN 1066

  Fly   561 PKRPRIRKTFVVRKQARTNSAGDTPLTNRPLATEQCEITIENCCNMNICETPCF 614
            ||.|....:..||             :.||..||.         .|:.|..|.|
Human  1067 PKNPYEESSRDVR-------------SRRPADTED---------GMSSCPQPWF 1098

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cueNP_612113.2 TerD_like 48..>85 CDD:473128 9/54 (17%)
YvrE <73..>164 CDD:442613 23/123 (19%)
LY 101..141 CDD:214531 10/52 (19%)
Ldl_recept_b 167..208 CDD:459654 15/40 (38%)
LY 193..237 CDD:214531 19/43 (44%)
EGFNP_001954.2 TolB 47..190 CDD:440585
LDL-receptor class B 1 86..127
LDL-receptor class B 2 128..169
LY 152..189 CDD:214531
LDL-receptor class B 3 170..211
LDL-receptor class B 4 212..258
EGF_CA 356..395 CDD:214542
FXa_inhibition 408..436 CDD:464251
FXa_inhibition 439..476 CDD:464251 4/17 (24%)
LDL-receptor class B 5 483..523 7/39 (18%)
LY 505..546 CDD:214531 7/40 (18%)
LDL-receptor class B 6 524..566 9/41 (22%)
LY 547..587 CDD:214531 8/39 (21%)
LDL-receptor class B 7 567..609 8/44 (18%)
LY 590..633 CDD:214531 11/46 (24%)
LDL-receptor class B 8 610..653 16/43 (37%)
LY 635..676 CDD:214531 19/43 (44%)
LDL-receptor class B 9 654..696 14/44 (32%)
LY 677..718 CDD:214531 9/46 (20%)
FXa_inhibition 745..780 CDD:464251 5/34 (15%)
O-glycosylated at one site 801..807 0/5 (0%)
EGF 835..864 CDD:394967 10/32 (31%)
EGF_CA 870..910 CDD:214542 11/40 (28%)
EGF_CA 912..940 CDD:429571 7/27 (26%)
PHA03099 <976..>1014 CDD:165381 7/46 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1093 10/47 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1108..1131
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1177..1207
Blue background indicates that the domain is not in the aligned region.

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