DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cue and EGF

DIOPT Version :9

Sequence 1:NP_612113.2 Gene:cue / 38174 FlyBaseID:FBgn0011204 Length:644 Species:Drosophila melanogaster
Sequence 2:XP_016863334.1 Gene:EGF / 1950 HGNCID:3229 Length:1223 Species:Homo sapiens


Alignment Length:704 Identity:155/704 - (22%)
Similarity:258/704 - (36%) Gaps:199/704 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 SWQTIATAAH--EFDELSALTFDESEELIYFN--DLKHRN--------------GSIFSLKRDLI 93
            ||:......:  :.||.|.........|::.|  |::|.:              |.:::|..|.:
Human   466 SWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPV 530

  Fly    94 AAN----HVAEQTIART-------------GNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIHGS 141
            ...    |.|.:.|.|.             |.:...|||.|.:....:|:|..:..|..:.::|.
Human   531 ENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGK 595

  Fly   142 ATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIV 206
            .:..:..:..::   |.|:||....::|:||::.: :|.:|..:|.|..|.||.||::..|.||.
Human   596 RSKIITKENISQ---PRGIAVHPMAKRLFWTDTGI-NPRIESSSLQGLGRLVIASSDLIWPSGIT 656

  Fly   207 VDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEPLNLAVTNDAIYWTDRTTRAVWSH 271
            :|.|:|:|:|.|..:.|   :|.:.||||.|:.:.::....|..:||..|.::::|      |:.
Human   657 IDFLTDKLYWCDAKQSV---IEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSD------WAM 712

  Fly   272 PKVPVIKVTTTS----------KPDEEDSTDSTDFKDP--EPVAEDCPLVR--VANLSEEARGIV 322
            |.|..:...|..          ||      .|.....|  :|.|:.|....  ..::.::..|..
Human   713 PSVMRVNKRTGKDRVRLQGSMLKP------SSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTA 771

  Fly   323 ---ARTGFYQR------LQKDHHCASIVRKV-------------KERVDEQSRKFEIRSLLDQKI 365
               .|.||.:.      |..|.|......:|             |.||.|.:.. |.:.:|..:|
Human   772 WCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNIT-ESQHMLVAEI 835

  Fly   366 KVLEDE-----------RCMNDGEYRAATDLCICPTGF--KGSRC-EIRECH---NYC--VHGTC 411
            .|.:.:           ||:::||  .||  |.|..||  .|..| :|.||.   ..|  ....|
Human   836 MVSDQDDCAPVGCSMYARCISEGE--DAT--CQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKC 896

  Fly   412 QMSELAYPKCYCQPGFKG--------ERCELSVCS----GLCLN--GGHCRVSKDENEAPSCECP 462
            ..:|..| .|.|..|::|        :.|:|...|    ..|.|  ||:..:.......|...||
Human   897 INTEGGY-VCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICP 960

  Fly   463 AKFGGARCEQ--------NSTEICSL----FCRLLKHEPEMYV----PFGCHSICEELAQDNSTN 511
            .........:        ||...|.|    :|  |.....||:    .:.|:.:...:.:.    
Human   961 DSTPPPHLREDDHHYSVRNSDSECPLSHDGYC--LHDGVCMYIEALDKYACNCVVGYIGER---- 1019

  Fly   512 IAIPQYQHLEVCLTPRVW---------TSSVIIILVVGIVSSLLLVAVIVQGIR--RLYK----- 560
               .||:.|:       |         ....:|::.|.:|..::|:.:.:.|..  |..|     
Human  1020 ---CQYRDLK-------WWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKN 1074

  Fly   561 PKRPRIRKTFVVRKQARTNSAGDTPLTNRPLATEQCEITIENCCNMNICETPCF 614
            ||.|....:..||             :.||..||.         .|:.|..|.|
Human  1075 PKNPYEESSRDVR-------------SRRPADTED---------GMSSCPQPWF 1106

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cueNP_612113.2 LY 101..141 CDD:214531 10/52 (19%)
Ldl_recept_b 167..208 CDD:278487 15/40 (38%)
LY 193..237 CDD:214531 19/43 (44%)
EGFXP_016863334.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0.928771 Normalized mean entropy S7221
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.760

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