DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cue and rme-2

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_500815.2	Gene:	rme-2 / 177329	WormBaseID:	WBGene00004374	Length:	925	Species:	Caenorhabditis elegans

Alignment Length:	502	Identity:	103/502 - (20%)
Similarity:	181/502 - (36%)	Gaps:	153/502 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 DLKHRNGSIFSLKRDLIAANH--------VAEQTIARTGNESVGG---LAYDPLNMNLFW---SD 127
            |..|||..:|.    .|:..|        |::..:.|...|:|.|   :|.|.:..|:|:   |.
Worm   428 DFMHRNNKMFM----SISDEHGDPTGELSVSDNGLMRVLRENVIGVSNVAVDWIGGNVFFTQKSP 488

  Fly   128 TEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRT 192
            :....|....:.|....:| ::...:|....|:.|...|..:.|.:|...:..:...|:|||...
Worm   489 SPSAGISICTMSGMFCRRV-IEGKEQGQSYRGLVVHPMRGLIIWIDSYQKYHRIMMANMDGSQVR 552

  Fly   193 VIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEPLNLAVTNDA 257
            :::.:.:::|..:.:|.:...:::.|..:.:   :|...:|..:|:||:.:..|.|.::|..|..
Worm   553 ILLDNKLEVPSALAIDYIRHDVYFGDVERQL---IERVNIDTKERRVVISNGVHHPYDMAYFNGF 614

  Fly   258 IYWTDRTTRAVWSHPKVPVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIV 322
            :||.|      |....:.|.::|.                     ....|.| :...:....||.
Worm   615 LYWAD------WGSESLKVQEMTH---------------------HHSSPQV-IHTFNRYPYGIA 651

  Fly   323 ARTGFYQRLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATDLCI 387
            .....||.....:.|..:               |...|.   :.|.:.:..|        |..|:
Worm   652 VNHSLYQTGPPSNPCLEL---------------ECPWLC---VIVPKSDFIM--------TAKCV 690

  Fly   388 CPTGFKGSRCEIRECHNYCV---------------H-GTCQMSELAYPKCYCQPGFKGERCELSV 436
            ||.|:..|..|     |.|:               | |:..|:|      ||:.|.
Worm   691 CPDGYTHSVTE-----NSCIPPVTIEDEENLEKLSHIGSALMAE------YCEAGV--------- 735

  Fly   437 CSGLCLNGGHCRVSKDENEAPS---CECPAKFGGARCEQNSTEICSLFCRLLKHEPEMYVPFGCH 498
               .|:|||.||..::|:....   |:|...:.|..||           ||   .||.:
Worm   736 ---ACMNGGACRELQNEHGRAHRIVCDCEGPYDGQYCE-----------RL---NPEKF------ 777

  Fly   499 SICEELAQDNSTNIAIPQYQHLEVCLTPRVWTSSVIIILVVGIVSSL 545
            |..||  :|:|..:.:             :....:||:.||||::.|
Worm   778 SAMEE--EDSSLWLIV-------------LLLIFLIIVAVVGIIAFL 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	10/45 (22%)
		Ldl_recept_b	167..208	CDD:278487	7/40 (18%)
		LY	193..237	CDD:214531	5/43 (12%)
rme-2	NP_500815.2	LDLa	37..69	CDD:238060
		LDLa	75..109	CDD:238060
		LDLa	137..171	CDD:238060
		FXa_inhibition	309..337	CDD:291342
		vWFA	<337..375	CDD:294047
		Ldl_recept_b	527..568	CDD:278487	7/40 (18%)
		LY	552..594	CDD:214531	5/44 (11%)
		LY	595..634	CDD:214531	12/65 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810