DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cue and F14B4.1

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_492474.2	Gene:	F14B4.1 / 172750	WormBaseID:	WBGene00008779	Length:	722	Species:	Caenorhabditis elegans

Alignment Length:	456	Identity:	100/456 - (21%)
Similarity:	157/456 - (34%)	Gaps:	175/456 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 DTEQRKIFFAPIHGSATPQVLVDLSAEGGRP-----------DGVAVDVCRRKLY---------- 170
            |.::.::::|.|..:    |:..::.||..|           :|:|||...|.||
Worm   358 DVKENRLYYADIGAN----VIERMNIEGTFPQAVQRFDVDGLEGIAVDWIGRNLYSLRREDILVQ 418

  Fly   171 ----------WTN------SNVTHPT--------------VERINLDGSNRTVIISSNIDMPRGI 205
                      :.|      |...||.              :...::|||:...||:..|..|..:
Worm   419 SLDGRFRQPLYKNVMTLPRSITLHPAKGIMFVTDWSANAFIAAASMDGSHFRKIITERITWPNAV 483

  Fly   206 VVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEP--LNLAVTNDAIYWTDRTTRAV 268
            .||..:::::|.|   ....::||:.:||:.|:|::.|....|  ..||:.:|.:||||.|.|.
Worm   484 AVDIFAEKIYWAD---AFLDTIESANMDGTGRRVIIADAGSVPHVFGLAIADDYLYWTDWTYRG- 544

  Fly   269 WSHPKVPVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQK 333
                      :...:|.:.|:.|                             ::|:|.......|
Worm   545 ----------ILRANKHNGENIT-----------------------------VLAQTALLPYSLK 570

  Fly   334 DHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATDLCICPTGF----KG 394
            ..|        |....|::...|.|..         |:.|:. ||..|||  |.|..||    .|
Worm   571 VFH--------KSLQPEETSTCETRGC---------DQLCLL-GENGAAT--CACGEGFDLLNDG 615

  Fly   395 SRCEIRECHNYCVHGTCQMSEL----AYPKCYCQPGFKGERCELSVCSGLCLNGGHCRVSKDENE 455
            .:|.          ..|..|::    |.|||.         .::.:|.||    ..|....||.:
Worm   616 KKCS----------SNCSESQIECGGADPKCI---------SKIYLCDGL----AQCSNQADEEK 657

  Fly   456 APSCEC-PAKF-----------GG-----ARCEQNSTEICSLFCRLLK-HEPEMYV---PFGCHS 499
            .|...| |.:|           ||     ..|..:|.||   :|...| .|...:|   ..|.||
Worm   658 CPPRICLPGQFQCHDNHKCLPPGGLCDKVTDCSDSSDEI---YCEYQKTTEKGQFVLNTTKGKHS 719

  Fly   500 I 500
            |
Worm   720 I 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	3/13 (23%)
		Ldl_recept_b	167..208	CDD:278487	14/80 (18%)
		LY	193..237	CDD:214531	12/43 (28%)
F14B4.1	NP_492474.2	vWFA	<272..313	CDD:294047
		LY	343..383	CDD:214531	6/28 (21%)
		LY	391..425	CDD:214531	7/33 (21%)
		Ldl_recept_b	448..486	CDD:278487	7/37 (19%)
		LY	470..512	CDD:214531	12/44 (27%)
		LY	513..549	CDD:214531	12/46 (26%)
		FXa_inhibition	588..618	CDD:291342	12/41 (29%)
		LDLa	622..658	CDD:238060	12/48 (25%)
		LDLa	663..698	CDD:238060	9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900