DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cue and lrp-1

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001379135.1	Gene:	lrp-1 / 172520	WormBaseID:	WBGene00003071	Length:	4753	Species:	Caenorhabditis elegans

Alignment Length:	409	Identity:	97/409 - (23%)
Similarity:	150/409 - (36%)	Gaps:	128/409 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 IYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAP 137
            ||::|.|..|...|..         :.|..||         ||:|.|...::|||..::||..|.
Worm  1494 IYYSDHKLDNWHTFGA---------IVENAIA---------LAWDSLTDRIYWSDIREKKILSAN 1540

  Fly   138 IHG-SATPQVL--VDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINL-DGSNRTVIISSN 198
            .:| :||..:.  :|::      :|:|:|...|.|||.:|::.  |:|..|| |...||:::..|
Worm  1541 RNGTNATVFIADGLDIT------EGIALDWVGRNLYWVDSSLN--TIEVANLEDPKQRTLLVHQN 1597

  Fly   199 IDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEPLNLAV--TNDAIYWT 261
            :..||||.||.....:||.|  .|....:|.:.:||:|||:::|.|.:.|..:|:  |.|.:|:.
Worm  1598 VSQPRGIAVDPRKGVMFWTD--WGQNPCIERASMDGTDRQIIVKTKIYWPNTIALDYTTDRVYFA 1660

  Fly   262 DRTTRAVWSHPKVPVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEAR-GIVART 325
            |                          ...|..||               .|.....| .::|.:
Worm  1661 D--------------------------SKLDFIDF---------------VNYDGSGRTQVLASS 1684

  Fly   326 GFYQRLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATDLCICPT 390
            .|   :|..|..|                            :.||....:|   |....|.:.|.
Worm  1685 KF---VQHPHALA----------------------------IFEDMMYYSD---RRLQKLQVYPK 1715

  Fly   391 GFKGSRCEIRECHNYCVHGTCQMSELAYPKCYCQPGFKGERCELSVCSGLCLNGGHCRVSKDENE 455
            ...|:..|      |..|...:...:.......||..|...|..:.||.|||        .:...
Worm  1716 YPNGTTSE------YPSHTFSKALGVVAVHPVLQPVIKNNPCSTNPCSHLCL--------LNNKN 1766

  Fly   456 APSCECP----AKFGGARC 470
            ..:|:||    ....|.:|
Worm  1767 TFTCKCPMGEKLDASGKKC 1785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	13/40 (33%)
		Ldl_recept_b	167..208	CDD:278487	17/41 (41%)
		LY	193..237	CDD:214531	14/43 (33%)
lrp-1	NP_001379135.1	LDLa	53..87	CDD:238060
		LDLa	92..131	CDD:238060
		LDLa	140..173	CDD:238060
		LDLa	182..216	CDD:238060
		LDLa	223..257	CDD:238060
		LDLa	262..297	CDD:238060
		LY	463..505	CDD:214531
		LY	507..546	CDD:214531
		LY	547..589	CDD:214531
		LY	883..925	CDD:214531
		exchanger_TraA	<1054..1451	CDD:411343
		LDLa	1057..1087	CDD:197566
		LDLa	1146..1177	CDD:197566
		LDLa	1187..1219	CDD:238060
		LDLa	1228..1263	CDD:238060
		LDLa	1270..1302	CDD:238060
		LDLa	1313..1344	CDD:238060
		FXa_inhibition	1447..1475	CDD:405372
		LY	1511..1545	CDD:214531	14/42 (33%)
		LY	1548..1585	CDD:214531	12/44 (27%)
		LY	1590..1634	CDD:214531	16/45 (36%)
		LY	1635..1677	CDD:214531	13/82 (16%)
		Ldl_recept_b	1943..1986	CDD:423042
		LY	1971..2012	CDD:214531
		LY	2015..2052	CDD:214531
		LY	2193..2239	CDD:214531
		LY	2240..2283	CDD:214531
		LY	2284..2325	CDD:214531
		LY	2570..2612	CDD:214531
		LY	2613..2655	CDD:214531
		LDLa	2794..2824	CDD:197566
		LDLa	2834..2868	CDD:238060
		LDLa	2874..2907	CDD:197566
		LDLa	2961..2994	CDD:238060
		LDLa	3012..3038	CDD:238060
		LDLa	3048..3088	CDD:197566
		LDLa	3099..3131	CDD:197566
		LDLa	3140..3174	CDD:238060
		LDLa	3186..3218	CDD:197566
		FXa_inhibition	3276..3305	CDD:405372
		LY	3382..3424	CDD:214531
		Ldl_recept_b	3445..3490	CDD:395012
		LY	3476..3516	CDD:214531
		FXa_inhibition	3586..3623	CDD:405372
		LDLa	3627..3660	CDD:197566
		LDLa	3671..3705	CDD:238060
		LDLa	3792..3825	CDD:197566
		LDLa	3837..3868	CDD:238060
		LDLa	3878..3912	CDD:238060
		LDLa	3917..3951	CDD:238060
		LDLa	3958..3990	CDD:197566
		LDLa	4049..4083	CDD:238060
		FXa_inhibition	4097..>4121	CDD:405372
		EGF_CA	4132..4163	CDD:214542
		NHL	4219..>4431	CDD:302697
		NHL repeat	4219..4257	CDD:271320
		NHL repeat	4267..4330	CDD:271320
		NHL repeat	4333..4371	CDD:271320
		NHL repeat	4373..4410	CDD:271320
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810