Protein Alignment cue and lrp-2

DIOPT Version :10

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_491270.2
• Gene: lrp-2 / 171981
• WormBaseID: WBGene00003072
• Length: 4858
• Species: Caenorhabditis elegans
• Alignment Length: 803
• Identity: 161/803 - (20%)
• Similarity: 264/803 - (32%)
• Gaps: 289/803 - (35%)

  Fly    17 ATCLLTPAHGTPLEWDFAVTLRTKIQFMDSSWQTIATAAHEF----DELSALTFDESEELIYFND 77
            |.|...|.:.           |||..  ::..:.::.:|..|    :.|..::.:.|:..:.
 Worm  3934 ARCHCAPGYA-----------RTKND--ENECEPLSKSAEMFITNGNRLHLMSLENSQVSVL--- 3982

  Fly    78 LKHRNGSIFSLKRDLIAAN-----HVAEQTIART---GN---------------------ESVGG 113
                 ..:|::|.:||...     .|...|:..|   ||                     ||..|
 Worm  3983 -----RPVFNIKMNLIPGGIDFGYDVFRTTLMYTVGIGNSRVDIRSKKWSDGLIGSWGEEESTAG 4042

  Fly   114 L-AYDPLNMNLFWSDT----------EQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRR 167
            | .||.::.|::::::          .|..|:.|....::|..::|:.:   |..:.:|||..:|
 Worm  4043 LITYDFMHNNVYFTESSEQNRGVLFDRQANIYVAKAKDTSTRTLIVNST---GTINSLAVDPIKR 4104

  Fly   168 KLYWTNSNVTHPTVERINLDG-----------SNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLK 221
            .::||.| ...|.:...||||           .....::..||..|..:|:|..::||:|||.||
 Worm  4105 LIFWTTS-APVPRILSANLDGKPIAQPFKTGSQPHKALVERNIFEPTSMVLDFSNERLYWIDVLK 4168

  Fly   222 GVFFSVESSKLDGSDRQVVLK-DKHHEPLNLAVTNDAIY-------------WTDRTTRAVWSHP 272
            .   ::|:...||.||:.|.| :....|:.:.|....||             :|.:|.:.|....
 Worm  4169 R---TIETVSFDGRDRRTVRKFELGDTPVTMDVLGGYIYLITRQGSIHRMHKFTGKTNKYVQKIR 4230

  Fly   273 KV-PVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQKDHH 336
            :| |.|:: ..:.|.:...:..|..|:| ..::.||...|....::..||:
 Worm  4231 EVSPRIQI-RVAHPAKHTVSHITHQKNP-CQSDYCPSNTVCVPDQDKNGIL-------------- 4279

  Fly   337 CASIVRKVKERVDEQSRKFEI--RSLLDQKIKVLEDERCMNDGEYRAATD-------LCICPTGF 392
                   :.:.:....|.||:  :..:..:.|..|..:|   |:|....:       .|:||.||
 Worm  4280 -------IPKCLCGPGRFFEVSTKKCMQLREKDQEASQC---GDYFCYNNAGCSPQKTCVCPPGF 4334

  Fly   393 KGSRCEIRECHNYCVHG-TCQMSEL---------------------------------------- 416
            .|.:|||.||...|.:| ||.:.|.
 Worm  4335 YGRQCEINECSETCWNGETCAVQEFGSTTNVVCHCPSNYTQSSCATNVCEGVCGPRGSCKTVPCP 4399

  Fly   417 -------AYPKCYCQPGFKGERC----ELSVCSG------------------------------- 439
                   :|..|.|..|:.|..|    :..||.|
 Worm  4400 KDEPHCRSYSFCECDKGWTGPHCRHKADAKVCYGHCFSGGACDGEGPLNLRCSCGDGLTGNRCQN 4464

  Fly   440 ----LCLNGGHCRVSKDENEAPSCECPAKFGGARCEQNSTEICSLFCRLLKHEPEMYVPFG---- 496
                .|||||.|..:......|.|.||:.|.|..||:   .:|...|           |||
 Worm  4465 CVGHECLNGGFCSYANSNRSLPHCICPSGFTGDHCEE---YLCKDAC-----------PFGSKCT 4515

  Fly   497 -----------CHSICEELAQDNSTNIAIPQYQHLEVCLTPRVWTSSVIIILVVGIVSSLLLVAV 550
                       |.  ||:.|..::|:.:       .:|.....|..:
 Worm  4516 YDITKPMDPITCS--CEQNAAAHNTDCS-------PICQKQPNWCHN------------------ 4553

  Fly   551 IVQGIRRLYKPKRPRIRKTFVVRKQARTNSAG---DTPLTNRPLATEQCEITIENCCNMNICETP 612
               |.|.|..|..|.       :.:.....||   |.|:......|...:.||.|..:......|
 Worm  4554 ---GGRCLDTPGYPG-------KCKCLPRFAGPRCDVPVQCDDYCTNNSKCTITNGTHFECDCKP 4608

  Fly   613 CFDPKLVEQTLSKSSCKEDKKIL 635
            .|.....||....|.|..:.|.:
 Worm  4609 GFKGLRCEQETKCSECSNEAKCI 4631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	TerD_like	48..>85	CDD:473128	4/40 (10%)
		YvrE	<73..>164	CDD:442613	24/130 (18%)
		LY	101..141	CDD:214531	14/74 (19%)
		Ldl_recept_b	167..208	CDD:459654	13/51 (25%)
		LY	193..237	CDD:214531	15/43 (35%)
lrp-2	NP_491270.2	LDLa	80..119	CDD:197566
		LDLa	130..162	CDD:197566
		LY	668..702	CDD:214531
		LY	707..758	CDD:214531
		LY	759..801	CDD:214531
		LDLa	968..1000	CDD:197566
		LDLa	1013..1047	CDD:238060
		LDLa	1053..1087	CDD:238060
		LDLa	1098..1129	CDD:238060
		LDLa	1144..1175	CDD:238060
		LDLa	1182..1216	CDD:238060
		LDLa	1227..1261	CDD:197566
		FXa_inhibition	1276..1305	CDD:464251
		FXa_inhibition	1314..1344	CDD:464251
		LY	1421..1463	CDD:214531
		LY	1465..1508	CDD:214531
		LY	1521..1555	CDD:214531
		FXa_inhibition	2270..2309	CDD:464251
		YvrE	2360..>2531	CDD:442613
		LY	2480..2521	CDD:214531
		LDLa	2681..2715	CDD:238060
		LDLa	2717..2751	CDD:238060
		LDLa	<2774..2798	CDD:238060
		LDLa	2819..2851	CDD:238060
		LDLa	2856..2891	CDD:238060
		LDLa	2904..2938	CDD:238060
		LDLa	2988..3020	CDD:197566
		LY	3231..3270	CDD:214531
		Ldl_recept_b	3296..3336	CDD:459654
		LY	3319..3362	CDD:214531
		LY	3363..3404	CDD:214531
		LDLa	3481..3514	CDD:197566
		LDLa	3527..3564	CDD:197566
		LDLa	3574..3609	CDD:238060
		LDLa	3614..3649	CDD:197566
		LDLa	3659..3693	CDD:238060
		LDLa	3881..3912	CDD:238060
		LY	4084..4125	CDD:214531	13/44 (30%)
		LY	4139..4181	CDD:214531	15/44 (34%)