DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cue and lrp-2

DIOPT Version :9

Sequence 1:NP_612113.2 Gene:cue / 38174 FlyBaseID:FBgn0011204 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_491270.2 Gene:lrp-2 / 171981 WormBaseID:WBGene00003072 Length:4858 Species:Caenorhabditis elegans


Alignment Length:803 Identity:161/803 - (20%)
Similarity:264/803 - (32%) Gaps:289/803 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 ATCLLTPAHGTPLEWDFAVTLRTKIQFMDSSWQTIATAAHEF----DELSALTFDESEELIYFND 77
            |.|...|.:.           |||..  ::..:.::.:|..|    :.|..::.:.|:..:.   
 Worm  3934 ARCHCAPGYA-----------RTKND--ENECEPLSKSAEMFITNGNRLHLMSLENSQVSVL--- 3982

  Fly    78 LKHRNGSIFSLKRDLIAAN-----HVAEQTIART---GN---------------------ESVGG 113
                 ..:|::|.:||...     .|...|:..|   ||                     ||..|
 Worm  3983 -----RPVFNIKMNLIPGGIDFGYDVFRTTLMYTVGIGNSRVDIRSKKWSDGLIGSWGEEESTAG 4042

  Fly   114 L-AYDPLNMNLFWSDT----------EQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRR 167
            | .||.::.|::::::          .|..|:.|....::|..::|:.:   |..:.:|||..:|
 Worm  4043 LITYDFMHNNVYFTESSEQNRGVLFDRQANIYVAKAKDTSTRTLIVNST---GTINSLAVDPIKR 4104

  Fly   168 KLYWTNSNVTHPTVERINLDG-----------SNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLK 221
            .::||.| ...|.:...||||           .....::..||..|..:|:|..::||:|||.||
 Worm  4105 LIFWTTS-APVPRILSANLDGKPIAQPFKTGSQPHKALVERNIFEPTSMVLDFSNERLYWIDVLK 4168

  Fly   222 GVFFSVESSKLDGSDRQVVLK-DKHHEPLNLAVTNDAIY-------------WTDRTTRAVWSHP 272
            .   ::|:...||.||:.|.| :....|:.:.|....||             :|.:|.:.|....
 Worm  4169 R---TIETVSFDGRDRRTVRKFELGDTPVTMDVLGGYIYLITRQGSIHRMHKFTGKTNKYVQKIR 4230

  Fly   273 KV-PVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQKDHH 336
            :| |.|:: ..:.|.:...:..|..|:| ..::.||...|....::..||:              
 Worm  4231 EVSPRIQI-RVAHPAKHTVSHITHQKNP-CQSDYCPSNTVCVPDQDKNGIL-------------- 4279

  Fly   337 CASIVRKVKERVDEQSRKFEI--RSLLDQKIKVLEDERCMNDGEYRAATD-------LCICPTGF 392
                   :.:.:....|.||:  :..:..:.|..|..:|   |:|....:       .|:||.||
 Worm  4280 -------IPKCLCGPGRFFEVSTKKCMQLREKDQEASQC---GDYFCYNNAGCSPQKTCVCPPGF 4334

  Fly   393 KGSRCEIRECHNYCVHG-TCQMSEL---------------------------------------- 416
            .|.:|||.||...|.:| ||.:.|.                                        
 Worm  4335 YGRQCEINECSETCWNGETCAVQEFGSTTNVVCHCPSNYTQSSCATNVCEGVCGPRGSCKTVPCP 4399

  Fly   417 -------AYPKCYCQPGFKGERC----ELSVCSG------------------------------- 439
                   :|..|.|..|:.|..|    :..||.|                               
 Worm  4400 KDEPHCRSYSFCECDKGWTGPHCRHKADAKVCYGHCFSGGACDGEGPLNLRCSCGDGLTGNRCQN 4464

  Fly   440 ----LCLNGGHCRVSKDENEAPSCECPAKFGGARCEQNSTEICSLFCRLLKHEPEMYVPFG---- 496
                .|||||.|..:......|.|.||:.|.|..||:   .:|...|           |||    
 Worm  4465 CVGHECLNGGFCSYANSNRSLPHCICPSGFTGDHCEE---YLCKDAC-----------PFGSKCT 4515

  Fly   497 -----------CHSICEELAQDNSTNIAIPQYQHLEVCLTPRVWTSSVIIILVVGIVSSLLLVAV 550
                       |.  ||:.|..::|:.:       .:|.....|..:                  
 Worm  4516 YDITKPMDPITCS--CEQNAAAHNTDCS-------PICQKQPNWCHN------------------ 4553

  Fly   551 IVQGIRRLYKPKRPRIRKTFVVRKQARTNSAG---DTPLTNRPLATEQCEITIENCCNMNICETP 612
               |.|.|..|..|.       :.:.....||   |.|:......|...:.||.|..:......|
 Worm  4554 ---GGRCLDTPGYPG-------KCKCLPRFAGPRCDVPVQCDDYCTNNSKCTITNGTHFECDCKP 4608

  Fly   613 CFDPKLVEQTLSKSSCKEDKKIL 635
            .|.....||....|.|..:.|.:
 Worm  4609 GFKGLRCEQETKCSECSNEAKCI 4631

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cueNP_612113.2 LY 101..141 CDD:214531 14/74 (19%)
Ldl_recept_b 167..208 CDD:278487 13/51 (25%)
LY 193..237 CDD:214531 15/43 (35%)
lrp-2NP_491270.2 LDLa 80..119 CDD:197566
LDLa 130..162 CDD:197566
LY 668..702 CDD:214531
LY 707..758 CDD:214531
LY 759..801 CDD:214531
LDLa 968..1000 CDD:197566
LDLa 1013..1047 CDD:238060
LDLa 1053..1087 CDD:238060
LDLa 1098..1129 CDD:238060
LDLa 1144..1175 CDD:238060
LDLa 1182..1216 CDD:238060
FXa_inhibition 1276..1305 CDD:291342
LY 1421..1463 CDD:214531
LY 1465..1508 CDD:214531
LY 1521..1555 CDD:214531
LY 2480..2521 CDD:214531
LDLa 2681..2715 CDD:238060
LDLa 2717..2751 CDD:238060
LDLa <2774..2798 CDD:238060
LDLa 2819..2851 CDD:238060
LDLa 2856..2891 CDD:238060
LDLa 2904..2938 CDD:238060
LDLa 2988..3020 CDD:197566
LY 3231..3270 CDD:214531
Ldl_recept_b 3296..3336 CDD:278487
LY 3319..3362 CDD:214531
LY 3363..3404 CDD:214531
LDLa 3481..3514 CDD:197566
LDLa 3574..3609 CDD:238060
LDLa 3614..3649 CDD:197566
LDLa 3659..3693 CDD:238060
LDLa 3881..3912 CDD:238060
LY 4084..4125 CDD:214531 13/44 (30%)
LY 4139..4181 CDD:214531 15/44 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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