DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cue and Lrp8

DIOPT Version :9

Sequence 1:NP_612113.2 Gene:cue / 38174 FlyBaseID:FBgn0011204 Length:644 Species:Drosophila melanogaster
Sequence 2:XP_011238756.1 Gene:Lrp8 / 16975 MGIID:1340044 Length:1010 Species:Mus musculus


Alignment Length:598 Identity:120/598 - (20%)
Similarity:202/598 - (33%) Gaps:209/598 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 ALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGN-ESVGGLAYDPLNMNLFWS 126
            ||..:.:...||:.||.:|  .|:|...|  .|:...||.:..... .|..|||.|.::.:::|:
Mouse   501 ALDVEVATNRIYWCDLSYR--KIYSAHMD--KASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWT 561

  Fly   127 DTEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNR 191
            |:..:.|..|...|.....:   .|.|...|..:|||..|..:||::... ...:|:..|:|::|
Mouse   562 DSGNKTISVATTDGRRRCTL---FSRELSEPRAIAVDPLRGFMYWSDWGF-QAKIEKAGLNGADR 622

  Fly   192 TVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVL--KDKHHEPLNLAVT 254
            ..::|.||:.|.||.:|.||.||:|:|   .....:.|...:|.:|::::  .|....|..:||.
Mouse   623 QTLVSDNIEWPNGITLDLLSQRLYWVD---SKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVF 684

  Fly   255 NDAIYWTDRTTRAVWSHPKVPVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEAR 319
            .|.::|||....|::|..::..:::                                        
Mouse   685 EDKVFWTDLENEAIFSANRLNGLEI---------------------------------------- 709

  Fly   320 GIVARTGFYQRLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATD 384
            .|:|     :.|...|                                                |
Mouse   710 AILA-----ENLNNPH------------------------------------------------D 721

  Fly   385 LCICPTGFKGSRCEIRECHNYCVHGTCQMSELAYPKCYCQPGFKGERCELSV-----CSGLCLNG 444
            :.|                         ..||..||.       .:.|:||.     |..|||  
Mouse   722 IVI-------------------------FHELKQPKA-------ADACDLSAQPNGGCEYLCL-- 752

  Fly   445 GHCRVSKDENEAP--SCECPAKF----GGARC-----EQNSTEICSLFCRLLK----------HE 488
               ...:..:.:|  :|.||...    ...||     ..::|.:.|...|.:.          |:
Mouse   753 ---PAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASAMTRTVPATTRAPGTTIHD 814

  Fly   489 PEMYVPFGCHSICEELAQDNSTNIAIPQYQHLEVCLTPRVWTS--------------SVIIILVV 539
            | .|......:..:..|..:|.|  :|:....... ||...||              |.:...|:
Mouse   815 P-TYQNHSTETPSQTAAAPHSVN--VPRAPSTSPS-TPSPATSNHSQHYGNEGSQMGSTVTAAVI 875

  Fly   540 GIVSSLLLVAVIVQG---IRRLYKPK--------RPRIRKTFVVRKQ-----ARTNSAG---DTP 585
            |::..::::|::...   |.|.:|.|        .|..|||....::     .||...|   ...
Mouse   876 GVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAA 940

  Fly   586 LTN--RPLATEQC 596
            ::|  |||..|.|
Mouse   941 ISNYDRPLWAEPC 953

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cueNP_612113.2 LY 101..141 CDD:214531 10/40 (25%)
Ldl_recept_b 167..208 CDD:278487 12/40 (30%)
LY 193..237 CDD:214531 15/43 (35%)
Lrp8XP_011238756.1 LDLa 41..75 CDD:238060
LDLa 79..111 CDD:197566
LDLa 121..157 CDD:238060
LDLa 200..232 CDD:197566
LDLa 256..286 CDD:238060
LDLa 292..326 CDD:238060
LDLa 330..366 CDD:381805
FXa_inhibition 387..421 CDD:373209
EGF_CA 423..453 CDD:214542
LY 492..527 CDD:214531 9/27 (33%)
LY 537..578 CDD:214531 10/40 (25%)
Ldl_recept_b 599..639 CDD:278487 12/40 (30%)
LY 623..665 CDD:214531 15/44 (34%)
Ldl_recept_b 686..725 CDD:278487 12/156 (8%)
FXa_inhibition 744..781 CDD:373209 8/41 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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