Protein Alignment cue and Lrp6

DIOPT Version :10

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_032540.2
• Gene: Lrp6 / 16974
• MGIID: 1298218
• Length: 1613
• Species: Mus musculus
• Alignment Length: 405
• Identity: 99/405 - (24%)
• Similarity: 166/405 - (40%)
• Gaps: 112/405 - (27%)

  Fly    19 CLLTPAHGTPLEWDFAVTLRTKIQFMDSSWQTIATAAHE---------FDELSALTFDESEELIY 74
            ||::|.  .|.   :.....|.::.:::. :|....|.|         ...:|..|.|.::.::.
Mouse   297 CLMSPV--KPF---YQCACPTGVKLLENG-KTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQ 355

  Fly    75 FNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIH 139
            ..|::|                     .||         :.|||:...::|:|.|.|.|..:.|.
Mouse   356 LEDIRH---------------------AIA---------IDYDPVEGYIYWTDDEVRAIRRSFID 390

  Fly   140 GSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRG 204
            ||.:..|   ::|:...|||:|||...|.||||::......|.|:|  |:.|.::||.:::.||.
Mouse   391 GSGSQFV---VTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLN--GTMRKILISEDLEEPRA 450

  Fly   205 IVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEPLNLAVTND--AIYWTDRTTRA 267
            ||:|.:...::|.|  .|....:|.:.||||||.|::......|..||:..|  .|||.|..|
Mouse   451 IVLDPMVGYMYWTD--WGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKT-- 511

  Fly   268 VWSHPKVPVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQ 332
                .|:.|:            :||.|..:   .:.||    ::.::          .||  .|.
Mouse   512 ----DKIEVM------------NTDGTGRR---VLVED----KIPHI----------FGF--TLL 541

  Fly   333 KDH-HCASIVRKVKERVDEQSRKFEIRSLLDQ-----------KIKVLEDERCMNDGE------- 378
            .|: :.....|:..|||.::|.:.|:  ::||           ..:::....|..|..
Mouse   542 GDYVYWTDWQRRSIERVHKRSAEREV--IIDQLPDLMGLKATSVHRIIGSNPCAEDNGGCSHLCL 604

  Fly   379 YRAATDLCICPTGFK 393
            ||.....|.||.||:
Mouse   605 YRPQGLRCACPIGFE 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	TerD_like	48..>85	CDD:473128	8/45 (18%)
		YvrE	<73..>164	CDD:442613	22/90 (24%)
		LY	101..141	CDD:214531	11/39 (28%)
		Ldl_recept_b	167..208	CDD:459654	16/40 (40%)
		LY	193..237	CDD:214531	15/43 (35%)
Lrp6	NP_032540.2	YncE	1..204	CDD:442618
		Beta-propeller 1	20..275
		LY	89..127	CDD:214531
		Ldl_recept_b	150..191	CDD:459654
		LY	175..216	CDD:214531
		LY	217..251	CDD:214531
		LDL-receptor class B 5	236..277
		FXa_inhibition	286..323	CDD:464251	5/31 (16%)
		Beta-propeller 2	328..589		83/336 (25%)
		LY	353..393	CDD:214531	14/69 (20%)
		LY	397..437	CDD:214531	17/44 (39%)
		Ldl_recept_b	458..499	CDD:459654	14/42 (33%)
		LY	483..524	CDD:214531	15/58 (26%)
		LY	525..558	CDD:214531	8/51 (16%)
		FXa_inhibition	592..627	CDD:464251	9/28 (32%)
		Beta-propeller 3	631..890
		YncE	<654..813	CDD:442618
		LY	697..739	CDD:214531
		LY	827..866	CDD:214531
		FXa_inhibition	893..929	CDD:464251
		Beta-propeller 4	933..1202
		LY	958..998	CDD:214531
		YncE	<968..1075	CDD:442618
		Ldl_recept_b	1069..1110	CDD:459654
		LY	1094..1136	CDD:214531
		FXa_inhibition	1207..1243	CDD:464251
		LDLa	1249..1285	CDD:238060
		LDLa	1288..1322	CDD:238060
		LDLa	1326..1360	CDD:238060
		PPPSP motif A	1487..1493
		PPPSP motif B	1527..1534
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1556..1613
		PPPSP motif C	1568..1575
		PPPSP motif D	1588..1593
		PPPSP motif E	1603..1610