Protein Alignment cue and Lrp5

DIOPT Version :9

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_032539.2
• Gene: Lrp5 / 16973
• MGIID: 1278315
• Length: 1614
• Species: Mus musculus
• Alignment Length: 261
• Identity: 78/261 - (29%)
• Similarity: 133/261 - (50%)
• Gaps: 21/261 - (8%)

  Fly    12 LVLLLATCLLTPAHGTPLEWDFAVTLRTKIQFMDSSWQTIAT--AAHEFDELSALTFDESEELIY 74
            |:||:..|.|.||..:||   .....|..::.:|:....:.:  .|...::.:|:.|..|:..:|
Mouse    16 LLLLVLYCSLVPAAASPL---LLFANRRDVRLVDAGGVKLESTIVASGLEDAAAVDFQFSKGAVY 77

  Fly    75 FNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIH 139
            :.|:...     ::|:..:.....|.|.|..:|..|..|||.|.:...|:|:|:|..:|..|.::
Mouse    78 WTDVSEE-----AIKQTYLNQTGAAAQNIVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLN 137

  Fly   140 GSATPQVLV--DLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMP 202
            |::. :||.  ||.    :|..:|:|.....:|||:.... |.:||..:|||.|.:|:.|:|..|
Mouse   138 GTSR-KVLFWQDLD----QPRAIALDPAHGYMYWTDWGEA-PRIERAGMDGSTRKIIVDSDIYWP 196

  Fly   203 RGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEPLNLAVTNDAIYWTDRTTRA 267
            .|:.:|....:|:|. |.|..|  :..:.||||.||.|::.....|..|.::.|.:||||..||:
Mouse   197 NGLTIDLEEQKLYWA-DAKLSF--IHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRS 258

  Fly   268 V 268
            :
Mouse   259 I 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	14/39 (36%)
		Ldl_recept_b	167..208	CDD:278487	15/40 (38%)
		LY	193..237	CDD:214531	15/43 (35%)
Lrp5	NP_032539.2	Beta-propeller 1	31..287		71/246 (29%)
		NHL	<36..>168	CDD:302697	34/141 (24%)
		NHL repeat	64..103	CDD:271320	9/43 (21%)
		LY	101..141	CDD:214531	14/39 (36%)
		NHL repeat	106..147	CDD:271320	14/41 (34%)
		Ldl_recept_b	162..202	CDD:278487	15/40 (38%)
		LY	186..228	CDD:214531	15/44 (34%)
		LY	229..270	CDD:214531	11/31 (35%)
		LDL-receptor class B 5	247..289		7/13 (54%)
		FXa_inhibition	298..335	CDD:291342
		Beta-propeller 2	340..601
		LY	365..405	CDD:214531
		LY	407..449	CDD:214531
		LY	450..493	CDD:214531
		LY	494..536	CDD:214531
		LY	537..570	CDD:214531
		FXa_inhibition	604..639	CDD:291342
		Beta-propeller 3	643..902
		NHL	684..877	CDD:302697
		LY	709..751	CDD:214531
		NHL repeat	719..755	CDD:271320
		NHL repeat	762..801	CDD:271320
		NHL repeat	807..842	CDD:271320
		NHL repeat	846..870	CDD:271320
		FXa_inhibition	905..940	CDD:291342
		Beta-propeller 4	944..1211
		LY	969..1008	CDD:214531
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1002..1025
		LY	1059..1102	CDD:214531
		LY	1103..1145	CDD:214531
		FXa_inhibition	1216..1252	CDD:291342
		LDLa	1258..1294	CDD:238060
		LDLa	1297..1331	CDD:238060
		LDLa	1335..1369	CDD:238060
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1474..1498
		PPPSP motif A	1499..1505
		PPPSP motif B	1537..1544
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1567..1599
		PPPSP motif C	1573..1580
		PPPSP motif D	1590..1595
		PPPSP motif E	1604..1611

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810