DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cue and Lrp1

DIOPT Version :9

Sequence 1:NP_612113.2 Gene:cue / 38174 FlyBaseID:FBgn0011204 Length:644 Species:Drosophila melanogaster
Sequence 2:XP_036011543.1 Gene:Lrp1 / 16971 MGIID:96828 Length:4562 Species:Mus musculus


Alignment Length:545 Identity:137/545 - (25%)
Similarity:212/545 - (38%) Gaps:105/545 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 GLAYDPLNMNLFWSDTEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVT 177
            |:|.|.:..|::|:|:.:..|..|.:.|.....::..:..|   |..:.||..|..:||::.. .
Mouse  3980 GIAIDWVAGNVYWTDSGRDVIEVAQMKGENR
KTLISGMIDE---PHAIVVDPLRGTMYWSDWG-N 4040

  Fly   178 HPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLK 242
            ||.:|...:||:.|..::..||..|.|:.||..::||:|.|....|..|:   :|:|:|..|...
Mouse  4041 HPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSI---RLNGTDPIVAAD 4102

  Fly   243 DKH--HEPLNLAVTNDAIYWTDRTTRAVWSHPKV---PVIKVTTTSKPDEEDSTDSTDFKDPEPV 302
            .|.  ..|.::.|..|.||........|:...|.   |:|.: |.......|.......|.|| |
Mouse  4103 SKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLINL-TGGLSHASDVVLYHQHKQPE-V 4165

  Fly   303 AEDC---------------PLVRVANLSEEARGI------------VARTG-----------FYQ 329
            ...|               |:....|......|.            ..|.|           .:.
Mouse  4166 TNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCTLQCFNGGSCFL 4230

  Fly   330 RLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATD---LCICPTG 391
            ..::...|....|...::.:           |||..     |.|.|.|...|:..   .|.||||
Mouse  4231 NARRQPKCRCQPRYTGDKCE-----------LDQCW-----EYCHNGGTCAASPSGMPTCRCPTG 4279

  Fly   392 FKGSRCEIRECHNYCV-HGTCQMSELAYPKCYCQPGFKGERCELSVCSGLCLNGGHCRVSKDENE 455
            |.|.:|..:.|..||. :.||.:::...|:|.|.|||.|:||:...|||.|.|.|.|:::.|.:.
Mouse  4280 FTGPKCTAQVCAGYCSNNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGFCENFGTCQMAADGSR 4344

  Fly   456 APSCECPAKFGGARCEQNSTEIC-SLFCRLLKHEPEM-------YVPFGCHSICEELAQDNSTNI 512
              .|.|...|.|.|||.|....| ...|.:.|...::       .|...|.:..:..:...|..:
Mouse  4345 --QCRCTVYFEGPRCEVNKCSRCLQGACVVNKQTGDVTCNCTDGRVAPSCLTCIDHCSNGGSCTM 4407

  Fly   513 ---AIPQYQHLEVCLTPRV-----------WTSSVIIILVVGIVSSLLLVAVIVQGIRRLYKPKR 563
               .:|:.|.......||.           ..:|::|.|:      |||:.::|.|:...|| :|
Mouse  4408 NSKMMPECQCPPHMTGPRCEEQVVSQQQPGHMASILIPLL------LLLLLLLVAGVVFWYK-RR 4465

  Fly   564 PRIRKTFVVRKQARTNSAGDTPLTN 588
            .|..|.|  :.|..||.|.:..:.|
Mouse  4466 VRGAKGF--QHQRMTNGAMNVEIGN 4488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cueNP_612113.2 LY 101..141 CDD:214531 8/27 (30%)
Ldl_recept_b 167..208 CDD:278487 12/40 (30%)
LY 193..237 CDD:214531 14/43 (33%)
Lrp1XP_036011543.1 LDLa 27..60 CDD:197566
LDLa 72..105 CDD:197566
FXa_inhibition 120..149 CDD:405372
FXa_inhibition 159..189 CDD:405372
LY 276..315 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..520 CDD:405372
LY 552..594 CDD:214531
LY 595..634 CDD:214531
LY 641..690 CDD:214531
LY <701..734 CDD:214531
FXa_inhibition 808..843 CDD:405372
LDLa 854..886 CDD:197566
LDLa 896..929 CDD:238060
LDLa 936..968 CDD:197566
LDLa 979..1012 CDD:238060
LDLa 1033..1066 CDD:238060
LDLa 1080..1115 CDD:238060
LDLa 1122..1158 CDD:238060
LDLa 1163..1196 CDD:238060
FXa_inhibition 1203..1239 CDD:405372
LY 1354..1394 CDD:214531
LY 1398..1441 CDD:214531
LY 1442..1486 CDD:214531
LY 1631..1667 CDD:214531
LY 1668..1711 CDD:214531
LY 1715..1752 CDD:214531
LY 1752..1793 CDD:214531
FXa_inhibition 1868..1904 CDD:405372
LY 1934..1974 CDD:214531
LY 1977..2017 CDD:214531
LY 2018..2061 CDD:214531
LY 2063..2105 CDD:214531
FXa_inhibition 2177..2212 CDD:405372
YvrE 2271..2481 CDD:225921
Ldl_recept_b 2362..2403 CDD:395012
LY 2388..2429 CDD:214531
FXa_inhibition 2500..2532 CDD:405372
LDLa 2545..2575 CDD:238060
LDLa 2584..2618 CDD:238060
LDLa 2623..2657 CDD:238060
LDLa <2684..2706 CDD:238060
LDLa 2714..2748 CDD:238060
LDLa 2752..2783 CDD:197566
LDLa 2791..2824 CDD:197566
LDLa 2835..2867 CDD:197566
LDLa 2875..2908 CDD:197566
LDLa 2925..2957 CDD:238060
cEGF 2980..3003 CDD:403760
EGF_CA 3000..>3029 CDD:214542
LY 3067..3111 CDD:214531
LY 3112..3154 CDD:214531
LY 3156..3198 CDD:214531
LY 3200..3241 CDD:214531
LY 3242..3282 CDD:214531
FXa_inhibition 3312..3348 CDD:405372
LDLa 3352..3383 CDD:238060
LDLa 3392..3426 CDD:238060
LDLa 3431..3466 CDD:238060
LDLa 3470..3503 CDD:197566
LDLa 3511..3544 CDD:197566
LDLa 3554..3588 CDD:238060
LDLa 3593..3627 CDD:238060
LDLa 3631..3665 CDD:238060
LDLa 3671..3703 CDD:197566
LDLa 3713..3749 CDD:238060
LDLa 3764..3794 CDD:238060
LY 3973..4010 CDD:214531 9/29 (31%)
Ldl_recept_b 4031..4071 CDD:395012 12/40 (30%)
LY 4055..4096 CDD:214531 14/43 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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