DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cue and Ldlr

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_034830.2	Gene:	Ldlr / 16835	MGIID:	96765	Length:	862	Species:	Mus musculus

Alignment Length:	233	Identity:	62/233 - (26%)
Similarity:	109/233 - (46%)	Gaps:	33/233 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 ELSALTFDESE--------------------ELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIA 104
            |:..:|.|.||                    ..||::||..:  .|:|...|  .|.:::..||.
Mouse   409 EVRKMTLDRSEYTSLLPNLKNVVALDTEVTNNRIYWSDLSQK--KIYSALMD--QAPNLSYDTII 469

  Fly   105 RTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKL 169
            .....:..|||.|.::.|::|:|:....:..|...|.....:..:   .|.||..:.||.....:
Mouse   470 SEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKRRTLFQE---AGSRPRAIVVDPVHGFM 531

  Fly   170 YWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDG 234
            |||:.. |...:::..|:|.:...:::.||..|.||.:|..|.||:|:|   ....|:.|..::|
Mouse   532 YWTDWG-TPAKIKKGGLNGVDIHSLVTENIQWPNGITLDLSSGRLYWVD---SKLHSISSIDVNG 592

  Fly   235 SDRQVVLKDKHH--EPLNLAVTNDAIYWTDRTTRAVWS 270
            .:|:.:|:|::.  .|.:||:..|.:||||....|::|
Mouse   593 GNRKTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFS 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	10/39 (26%)
		Ldl_recept_b	167..208	CDD:278487	11/40 (28%)
		LY	193..237	CDD:214531	14/43 (33%)
Ldlr	NP_034830.2	Ldl_recept_a	25..58	CDD:278486
		Ldl_recept_a	66..104	CDD:278486
		Ldl_recept_a	107..143	CDD:278486
		Ldl_recept_a	146..184	CDD:278486
		Ldl_recept_a	196..232	CDD:278486
		Ldl_recept_a	236..271	CDD:278486
		Ldl_recept_a	279..309	CDD:278486
		FXa_inhibition	319..>347	CDD:291342
		EGF_CA	355..389	CDD:214542
		LDL-receptor class B 1	398..439		5/29 (17%)
		LY	420..458	CDD:214531	6/39 (15%)
		LDL-receptor class B 2	440..485		14/48 (29%)
		Ldl_recept_b	440..482	CDD:278487	13/45 (29%)
		LDL-receptor class B 3	486..528		10/44 (23%)
		Ldl_recept_b	486..525	CDD:278487	8/41 (20%)
		LDL-receptor class B 4	529..572		12/43 (28%)
		Ldl_recept_b	529..569	CDD:278487	11/40 (28%)
		LY	553..595	CDD:214531	14/44 (32%)
		LDL-receptor class B 5	573..615		13/44 (30%)
		LDL-receptor class B 6	616..658		7/15 (47%)
		Ldl_recept_b	616..655	CDD:278487	7/15 (47%)
		FXa_inhibition	675..712	CDD:291342
		Clustered O-linked oligosaccharides	722..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..761
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250\|UniProtKB:P01130	813..862
		NPXY motif. /evidence=ECO:0000250\|UniProtKB:P01130	825..830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810