DRSC/TRiP Functional Genomics Resources

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Protein Alignment cue and Lrp2

DIOPT Version :10

Sequence 1:NP_612113.2 Gene:cue / 38174 FlyBaseID:FBgn0011204 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_001074557.1 Gene:Lrp2 / 14725 MGIID:95794 Length:4660 Species:Mus musculus


Alignment Length:430 Identity:95/430 - (22%)
Similarity:176/430 - (40%) Gaps:103/430 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 KIQFMDSSWQTIATAAHEFDELSALTFDESEE-----LIYFNDLKHRNGSIF-SLKRDLI----- 93
            :|:..:.|.:..:....|.:.:.|:.:|...|     ::|:..|.  .||.| ::||..:     
Mouse  4065 RIRKYNISSEKFSEYLEEEEHIQAIDYDWDPEGIGLSVVYYTVLS--QGSQFGAIKRAYLPDFES 4127

  Fly    94 -AANHVAEQTIARTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIHGSATPQVLVDLSAEGGRP 157
             :.|.|.|..:.........|||.|.:..:::|||.:.::|..|.:.|.....:   ::.:..:|
Mouse  4128 GSNNPVREVDLGLKYLMQPDGLAVDWVGRHIYWSDAKSQRIEVATLDGRYRKWL---ITTQLDQP 4189

  Fly   158 DGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIVVDQLS-DRLFWIDDLK 221
            ..:||:.....::||:.. ..|.:|...::|.:|:|:.|:|:..|.|:.:|.|: ||::|.|..:
Mouse  4190 AAIAVNPKLGLMFWTDQG-KQPKIESAWMNGEHRSVLASANLGWPNGLSIDYLNGDRIYWSDSKE 4253

  Fly   222 GVFFSVESSKLDGSDRQVVLKDKHHEPLNLAVTNDAIYWTDRTTRAVWSHPKVPVIKVTTTSKPD 286
            .|   :||.|.||:||::::.|. .:|.:|.:..|.:||..:....||...|.        .|.:
Mouse  4254 DV---IESIKYDGTDRRLIINDA-MKPFSLDIFEDQLYWVAKEKGEVWRQNKF--------GKGN 4306

  Fly   287 EEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQKDHHCASIVRKVKERVDEQ 351
            :|.                   :.|.|      ..:.:...:.:|:.:...::..::|...:   
Mouse  4307 KEK-------------------LLVVN------PWLTQVRIFHQLRYNQSVSNPCKQVCSHL--- 4343

  Fly   352 SRKFEIRSLLDQKIKVLEDERC-MNDGEYRAATDLCICPTG---FKGSRCEI-----------RE 401
                                 | :..|.|.     |.||.|   ..||..|.           ..
Mouse  4344 ---------------------CLLRPGGYS-----CACPQGSDFVTGSTVECDAASELPITMPSP 4382

  Fly   402 CHNYCVH-GTCQMSELAYPKCYCQPGFKGERCELSVCSGL 440
            |.  |:| |:|...|...|||.|..|:.||.||:.:..|:
Mouse  4383 CR--CMHGGSCYFDENDLPKCKCSSGYSGEYCEIGLSRGI 4420

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cueNP_612113.2 TerD_like 48..>85 CDD:473128 7/41 (17%)
YvrE <73..>164 CDD:442613 23/97 (24%)
LY 101..141 CDD:214531 9/39 (23%)
Ldl_recept_b 167..208 CDD:459654 11/40 (28%)
LY 193..237 CDD:214531 17/44 (39%)
Lrp2NP_001074557.1 LDLa 28..62 CDD:238060
LDLa 67..99 CDD:197566
LDLa 108..142 CDD:238060
LDLa 148..179 CDD:238060
LDLa 183..217 CDD:238060
LDLa 222..256 CDD:238060
LDLa 265..299 CDD:238060
YncE <427..576 CDD:442618
LDL-receptor class B 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 435..477
LDL-receptor class B 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 478..520
LY 502..547 CDD:214531
LDL-receptor class B 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 521..567
LY 550..590 CDD:214531
LDL-receptor class B 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 568..612
FXa_inhibition 662..703 CDD:464251
LDL-receptor class B 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 752..794
LY 775..817 CDD:214531
LDL-receptor class B 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 795..836
LDL-receptor class B 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 837..880
Ldl_recept_b 837..878 CDD:459654
LY 863..903 CDD:214531
LDL-receptor class B 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 881..924
FXa_inhibition 980..1012 CDD:464251
LDLa 1025..1059 CDD:238060
Ldl_recept_a 1065..1101 CDD:395011
LDLa 1110..1144 CDD:238060
LDLa 1150..1184 CDD:238060
LDLa 1188..1223 CDD:238060
LDLa 1231..1263 CDD:197566
LDLa 1272..1306 CDD:238060
LDLa 1313..1345 CDD:197566
FXa_inhibition 1354..1389 CDD:464251
EGF_CA 1391..1430 CDD:214542
LDL-receptor class B 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1479..1521
LY 1502..1544 CDD:214531
LDL-receptor class B 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1522..1564
LY 1546..1590 CDD:214531
LDL-receptor class B 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1567..1610
LY 1592..1633 CDD:214531
LDL-receptor class B 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1611..1655
LDL-receptor class B 13. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1656..1696
FXa_inhibition 1710..1741 CDD:464251
LDL-receptor class B 14. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1791..1833
LDL-receptor class B 15. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1834..1883
LDL-receptor class B 16. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1884..1931
Ldl_recept_b 1884..1929 CDD:459654
LY 1912..1954 CDD:214531
LDL-receptor class B 17. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1932..1973
LDL-receptor class B 18. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1974..2014
YncE 2035..2277 CDD:442618
LDL-receptor class B 19. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2108..2157
LDL-receptor class B 20. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2158..2202
LY 2183..2226 CDD:214531
LDL-receptor class B 21. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2203..2246
LDL-receptor class B 22. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2247..2290
LDL-receptor class B 23. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2291..2333
FXa_inhibition 2347..2383 CDD:464251
LDL-receptor class B 24. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2432..2478
LY 2460..2501 CDD:214531
LDL-receptor class B 25. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2479..2519
LY 2503..2543 CDD:214531
LDL-receptor class B 26. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2520..2563
LDL-receptor class B 27. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2564..2605
LY <2595..2626 CDD:214531
LDL-receptor class B 28. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2606..2647
FXa_inhibition 2656..2693 CDD:464251
LDLa 2700..2732 CDD:197566
LDLa 2742..2776 CDD:238060
LDLa 2783..2818 CDD:238060
LDLa 2822..2855 CDD:197566
LDLa 2865..2899 CDD:238060
LDLa 2908..2939 CDD:197566
LDLa 2950..2986 CDD:197566
LDLa 2995..3029 CDD:238060
LDLa 3034..3066 CDD:238060
LDLa 3077..3111 CDD:238060
FXa_inhibition 3124..3152 CDD:464251
vWFA <3149..3192 CDD:469594
LY 3221..3262 CDD:214531
LDL-receptor class B 29. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3241..3283
LY 3264..3306 CDD:214531
Ldl_recept_b 3284..3332 CDD:459654
LDL-receptor class B 30. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3284..3326
LDL-receptor class B 31. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3335..3378
Ldl_recept_b 3335..3376 CDD:459654
LY 3360..3401 CDD:214531
LDL-receptor class B 32. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3379..3421
LY 3406..3443 CDD:214531
LDL-receptor class B 33. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3422..3462
FXa_inhibition 3471..>3500 CDD:464251
LDLa 3514..3548 CDD:238060
LDLa 3555..3586 CDD:197566
LDLa 3595..3627 CDD:197566
LDLa 3636..3668 CDD:197566
LDLa 3684..3716 CDD:238060
LDLa 3723..3756 CDD:238060
LDLa 3761..3795 CDD:238060
LDLa 3800..3834 CDD:238060
LDLa 3844..3876 CDD:238060
LDLa 3887..3917 CDD:197566
LDLa 3930..3964 CDD:238060
EGF_CA 4009..4049 CDD:214542
LY 4143..4178 CDD:214531 10/34 (29%)
LDL-receptor class B 34. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4156..4198 9/44 (20%)
LDL-receptor class B 35. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4199..4242 12/43 (28%)
Ldl_recept_b 4199..4240 CDD:459654 11/41 (27%)
LY 4224..4266 CDD:214531 17/44 (39%)
LDL-receptor class B 36. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4244..4285 15/44 (34%)
FXa_inhibition 4340..>4358 CDD:464251 6/46 (13%)
SH3-binding. /evidence=ECO:0000255 4454..4463
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4457..4462
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4460..4465
Endocytosis signal. /evidence=ECO:0000255 4522..4527
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4558..4660
Interaction with DAB2. /evidence=ECO:0000250|UniProtKB:P98164 4597..4610
NPXY motif 4603..4606
SH2-binding. /evidence=ECO:0000255 4606..4609
SH3-binding. /evidence=ECO:0000255 4619..4630
Blue background indicates that the domain is not in the aligned region.

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