Protein Alignment cue and LRP1

DIOPT Version :10

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_320185.5
• Gene: LRP1 / 1280340
• VectorBaseID: AGAMI1_005394
• Length: 4869
• Species: Anopheles gambiae
• Alignment Length: 717
• Identity: 151/717 - (21%)
• Similarity: 234/717 - (32%)
• Gaps: 247/717 - (34%)

  Fly    17 ATCLLTPAHG----------------TPL------------EWDFAVTLRTKIQFMDSSWQTI-- 51
            |||:.....|                ||:            .:|||:|......|...|:.|.
Mosquito  3994 ATCVAVDEQGILLVASESDFRSLYADTPVMGYLQTSSLKIDRFDFAITRHNITLFWIDSYDTSIN 4058

  Fly    52 --------------------------------ATAAHEFDELSALTFDESEELIYFNDLKHRNGS 84
                                            |.|...:|.:..|            |.||   |
Mosquito  4059 KILMDTTVKDGGDYSRSPPVDKRKIVRRGLGPAPAPPSYDRIKTL------------DGKH---S 4108

  Fly    85 IFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIHGSATPQVLVD 149
            ...||.|.|       ..||         :|.|.|...|:..:.::..||....:|:..    ..
Mosquito  4109 SVVLKDDEI-------HPIA---------IACDWLTERLYVINKKRSNIFVMSFNGTNH----TT 4153

  Fly   150 LSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRL 214
            |:|.|..|..:.||.....:.|:    ...|:....:||..:..::.:|::...|:.:|..:.||
Mosquito  4154 LTATGKHPIDLVVDPVSGMMVWS----IMETIISSGMDGRGKQKLVHTNVEWASGLAIDTTTKRL 4214

  Fly   215 FWIDDLKGVFFSVESS-KLDGSDRQVV--LKDKHHEPLNLAVTNDAIYWTDRTTRAVWSHPKVPV 276
            :|.|..|.   ::|:. .|.|.||.|:  |.| :.:|..|.|..|::|                |
Mosquito  4215 YWADYRKS---TIETCLLLTGGDRHVIAELHD-YSKPKLLDVFEDSVY----------------V 4259

  Fly   277 I----KVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTG-------FYQR 330
            |    .:...:|...::.|                     .::|||||.....|       |...
Mosquito  4260 ILYNQNILKLNKYGRDNGT---------------------YMNEEARGAGGLAGYRSSDVHFIHP 4303

  Fly   331 LQKD------------HHCA----SIVRKVKERV---DEQSR-----KFEIRSLLDQKIKVLEDE 371
            |:.|            |:..    |.|.::|...   |.:||     :.|::..||...:..|.:
Mosquito  4304 LKHDRSVPNPCIISPCHNSTVCLLSTVSRLKRACVCPDARSRIVFDERGEVKECLDLPAQAPECK 4368

  Fly   372 RCMNDGEYRAATD---LCICPTGFKGSRCEIRECHNYCVH-GTCQMSELAYPKCYCQPGFKGERC 432
            ...|:|.....||   .|.|...|.|..|:...|..||.: |.|::.. ..|:|.|.|.:.|.||
Mosquito  4369 LHCNNGTCFIDTDGQQKCKCSASFDGKYCDHYICSGYCKNKGFCELVN-GEPQCTCLPQWTGTRC 4432

  Fly   433 ELSV--CSGLCLNGGHCRVSKDENEAPSCECPAKFGGARCEQNSTEICSL--FCRLLKHE----- 488
            ::|.  |...|.|||:|.:.:.:..:.||.||..:.|.:||..|...|..  .||....:
Mosquito  4433 DISTNKCQRYCHNGGNCTIVQRDGGSLSCSCPVGYTGEQCEHCSNLRCENGGVCRKTTTDRSQCL 4497

  Fly   489 -PEMYVPFGCH-SICEELAQDNSTNIAIPQYQHLEVCLTPRVWTSSVIIILVVGIVSSLLLVAVI 551
             .|.||...|. ::|.|..::...                                      ..|
Mosquito  4498 CAEGYVGRNCEKNVCTEFCENGGE--------------------------------------CTI 4524

  Fly   552 VQGIRRLYKPKRPRIRKTFVVRKQAR-----TNSAGDTPLTNRPLATEQCEITIEN-CCNMNICE 610
            .:|..:...|:     .|:..|.|.|     ..:.||.....||..  :|....|. .|..::||
Mosquito  4525 ERGAAKCSCPE-----NTYGERCQLRQCADLCRNGGDCVPGERPYC--KCRQGYEGPYCEHDLCE 4582

  Fly   611 TP 612
            .|
Mosquito  4583 LP 4584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	TerD_like	48..>85	CDD:473128	8/70 (11%)
		YvrE	<73..>164	CDD:442613	22/90 (24%)
		LY	101..141	CDD:214531	8/39 (21%)
		Ldl_recept_b	167..208	CDD:459654	6/40 (15%)
		LY	193..237	CDD:214531	11/44 (25%)
LRP1	XP_320185.5	None