DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cue and LOC100536757

DIOPT Version :9

Sequence 1:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_021334054.1	Gene:	LOC100536757 / 100536757	-ID:	-	Length:	600	Species:	Danio rerio

Alignment Length:	258	Identity:	61/258 - (23%)
Similarity:	113/258 - (43%)	Gaps:	48/258 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AVTLRTKIQFMD---SSWQTIATAAHEFDELSALTFDESEELIYF----NDLKHRNGSIFSLKRD 91
            ||:.:..|:.||   |..:.|.........:|||   .:...:|:    ||:.:|        ..
Zfish   244 AVSTQEGIKMMDLSGSEERNITDKRLSPGPVSAL---NAHNTLYWSSPENDIIYR--------MS 297

  Fly    92 LIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIHGSATPQVLVDLSAEGGR 156
            |.:.:|  ...:....::.:.|||.|.::.:|:|..|..|.:..|.:..:....::..||    :
Zfish   298 LDSGDH--RPAVWLKASKGIVGLAVDWIHESLYWISTSTRALHMASLKNTKQRLLISGLS----K 356

  Fly   157 PDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISS--------NIDMPRGIVVDQLSDR 213
            |..|||......::|.....: ..:||:.|||.:|..::.|        ::|:|||:
Zfish   357 PTAVAVQPLLGYVFWAEGGES-ARIERVGLDGESRFALVVSFVRNPVAISLDIPRGL-------- 412

  Fly   214 LFWIDD-LKGVFFSVESSKLDGSDRQVVLKDKHH--EPLNLAVTNDAIYWTDRTTRAVWSHPK 273
            |:|.|. |:    |:.....||..|:.|::...:  :|..||:....:||:|:.|.::.|..|
Zfish   413 LYWADSGLR----SISRVLFDGQYRKTVVESNGYLDQPFGLAIFESRVYWSDQLTNSICSADK 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	LY	101..141	CDD:214531	9/39 (23%)
		Ldl_recept_b	167..208	CDD:278487	12/48 (25%)
		LY	193..237	CDD:214531	12/52 (23%)
LOC100536757	XP_021334054.1	LDLa	38..72	CDD:238060
		PRKCSH-like	<45..>112	CDD:193472
		LDLa	121..155	CDD:238060
		FXa_inhibition	160..193	CDD:317114
		Ldl_recept_b	367..407	CDD:278487	8/40 (20%)
		LY	393..433	CDD:214531	12/51 (24%)
		LY	434..476	CDD:214531	10/38 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900