Protein Alignment cue and lrp2

DIOPT Version :10

• Sequence 1: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_012826499.2
• Gene: lrp2 / 100489914
• XenbaseID: XB-GENE-486052
• Length: 4662
• Species: Xenopus tropicalis
• Alignment Length: 516
• Identity: 122/516 - (23%)
• Similarity: 207/516 - (40%)
• Gaps: 147/516 - (28%)

  Fly    63 ALTFDESEELIYFNDLKHRNG------SIFSLK-----RDLIAANHVAEQTIARTGNESVGGLAY 116
            ||.:|..:..:||.   ..:|      |.|||.     |..:|::..|..           |:|:
 Frog  2428 ALDYDSLDNRVYFT---QSSGAGRSRISYFSLSSPSGPRTTVASDLGAPD-----------GIAF 2478

  Fly   117 DPLNMNLFWSDTEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTV 181
            |.::..:::||...:.|....::||....:     |...||..:.:|.||..:|||:.. |:..:
 Frog  2479 DWIHKRVYYSDYLNQTINSMAVNGSDRTVI-----ARVQRPRAIMLDPCRGYMYWTDWG-TNAKI 2537

  Fly   182 ERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWID-DLKGVFFSVESSKLDGSDRQVVLKDKH 245
            ||..|.|:.||.|:::::..|.|:.:|...:||:|.| :|:    .:|...|.|::|:||:....
 Frog  2538 ERATLGGNFRTAIVNTSLVWPNGLTLDYEEERLYWADANLQ----KIERCSLTGTNREVVVSTAV 2598

  Fly   246 HEPLNLAVTNDAIYWTDRTTRAVW---SH------------PKVPV-IKVTTTSKPDEEDSTDST 294
            : |..:.:.:..|||||..||:::   .|            |:.|: |.|.:.:| .::.|:...
 Frog  2599 Y-PFAMTLYDQHIYWTDWNTRSIYRANKHDGSDQIIMIQNLPQRPMDIHVLSKNK-QQQCSSPCD 2661

  Fly   295 DFKD-------PEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQKDHHCASIVRKVKERVDEQS 352
            .|..       |.|...:|.              ...:|.:.....:..|.         ||..:
 Frog  2662 QFNGGCSHICAPGPNGAECQ--------------CPASGRWYLANNNKDCI---------VDNGT 2703

  Fly   353 R----KFEIRSLLDQKIKVLEDERCMNDGEYRAATD----LC---ICP-TGFK--GSRC---EIR 400
            |    ||   :.|:.:. :.|..:|.||.:.|..:|    :|   .|| |.|.  ..||   ..|
 Frog  2704 RCENGKF---TCLNGRC-IPERHKCDNDNDCRDGSDELERVCAFHTCPSTSFTCGNGRCVPYHYR 2764

  Fly   401 ECHNY-----------CVHGTCQMSELAYPKCYCQPGFKGERC--ELSVCSGL--CLNGGHCRVS 450
             |.:|           |:..||..:    .:..|..|    ||  ...||:|:  |.:.|    :
 Frog  2765 -CDHYNDCGDNSDELGCLFRTCDPN----TEFTCNNG----RCISRAYVCNGVNNCFDNG----T 2816

  Fly   451 KDENEAPSCECPAKFGGARCEQNSTEICSLFCRLLKHEPEMYVPFGCHSICEELAQDNSTN 511
            .||...|...|..  |..:|  .||.||.         |..|:..|.:. |.:::.::.|:
 Frog  2817 SDERNCPDRTCQP--GYTKC--RSTNICI---------PRTYLCDGDND-CGDMSDESPTH 2863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cue	NP_612113.2	TerD_like	48..>85	CDD:473128	6/27 (22%)
		YvrE	<73..>164	CDD:442613	21/101 (21%)
		LY	101..141	CDD:214531	6/39 (15%)
		Ldl_recept_b	167..208	CDD:459654	13/40 (33%)
		LY	193..237	CDD:214531	12/44 (27%)
lrp2	XP_012826499.2	LDLa	33..67	CDD:238060
		LDLa	111..145	CDD:238060
		LDLa	151..182	CDD:238060
		LDLa	186..220	CDD:238060
		LDLa	266..300	CDD:238060
		EGF_CA	348..385	CDD:214542
		YncE	389..577	CDD:442618
		LY	503..548	CDD:214531
		LY	551..591	CDD:214531
		FXa_inhibition	663..704	CDD:464251
		LY	776..818	CDD:214531
		Ldl_recept_b	838..879	CDD:459654
		LY	864..904	CDD:214531
		FXa_inhibition	981..1013	CDD:464251
		LDLa	1026..1060	CDD:238060
		LDLa	1067..1101	CDD:238060
		LDLa	1109..1143	CDD:238060
		LDLa	1149..1183	CDD:238060
		LDLa	1187..1222	CDD:238060
		LDLa	1230..1264	CDD:238060
		LDLa	1271..1305	CDD:238060
		LDLa	1311..1344	CDD:197566
		FXa_inhibition	1358..1393	CDD:464251
		EGF_CA	1395..1434	CDD:214542
		Ldl_recept_b	1483..1523	CDD:459654
		LY	1506..1548	CDD:214531
		LY	1550..1594	CDD:214531
		LY	1596..1637	CDD:214531
		FXa_inhibition	1714..1745	CDD:464251
		YncE	1754..1984	CDD:442618
		LY	1825..1857	CDD:214531
		Ldl_recept_b	1888..1932	CDD:459654
		LY	1917..1958	CDD:214531
		FXa_inhibition	2027..2063	CDD:464251
		Vgb	2090..>2298	CDD:443399
		LY	2187..2230	CDD:214531
		LY	2232..2272	CDD:214531
		FXa_inhibition	2351..2387	CDD:464251
		Vgb	2416..2647	CDD:443399	64/243 (26%)
		LY	2463..2505	CDD:214531	11/52 (21%)
		Ldl_recept_b	2524..2565	CDD:459654	13/41 (32%)
		LY	2550..2590	CDD:214531	12/43 (28%)
		FXa_inhibition	2660..2697	CDD:464251	5/50 (10%)
		LDLa	2705..2737	CDD:238060	9/35 (26%)
		LDLa	2746..2780	CDD:238060	9/34 (26%)
		LDLa	2785..2822	CDD:238060	12/48 (25%)
		LDLa	2826..2859	CDD:197566	11/46 (24%)
		LDLa	2868..2900	CDD:197566
		LDLa	2910..2942	CDD:197566
		LDLa	2953..2993	CDD:238060
		LDLa	2998..3032	CDD:238060
		LDLa	<3046..3068	CDD:197566
		LDLa	3080..3114	CDD:238060
		FXa_inhibition	3126..3155	CDD:464251
		vWFA	<3152..3195	CDD:469594
		LY	3224..3265	CDD:214531
		LY	3267..3309	CDD:214531
		Ldl_recept_b	3338..3379	CDD:459654
		LY	3363..3404	CDD:214531
		LY	3405..3446	CDD:214531
		LDLa	3517..3549	CDD:238060
		LDLa	3558..3589	CDD:197566
		LDLa	3598..3630	CDD:197566
		LDLa	3639..3671	CDD:197566
LDLa	3724..3759	CDD:238060
LDLa	3764..3798	CDD:238060
LDLa	3802..3834	CDD:197566
LDLa	3847..3879	CDD:238060
LDLa	3890..3920	CDD:197566
LDLa	3933..3967	CDD:238060
LY	4146..4181	CDD:214531
Ldl_recept_b	4202..4243	CDD:459654
LY	4226..4269	CDD:214531
FXa_inhibition	4344..4371	CDD:464251