DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hfp and Puf60

DIOPT Version :9

Sequence 1:	NP_525123.2	Gene:	hfp / 38173	FlyBaseID:	FBgn0028577	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_006241956.2	Gene:	Puf60 / 84401	RGDID:	621674	Length:	564	Species:	Rattus norvegicus

Alignment Length:	633	Identity:	303/633 - (47%)
Similarity:	379/633 - (59%)	Gaps:	134/633 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TKRTRSDSGKSTDSKIPYLSQPLYDLKQTGDVKFGPGTRSALLGLLGGALPKLSSEQHDLVSKAK 89
            |:..:.::|:||.:|:                                .||.|:.||.:.:.|||
  Rat    44 TESIKMENGQSTGTKL--------------------------------GLPPLTPEQQEALQKAK 76

  Fly    90 KYAMEQSIKMVLMKQTLAHQQQQLAT-----------------QRTQVQRQQALALMCRVYVGSI 137
            |||||||||.||:|||:|||||||..                 |....|||:|||:|||||||||
  Rat    77 KYAMEQSIKSVLVKQTIAHQQQQLTNLQMAAVTMGFGDPLSPLQSMAAQRQRALAIMCRVYVGSI 141

  Fly   138 SFELKEDTIRVAFTPFGPIKSINMSWDPITQKHKGFAFVEYEIPEGAQLALEQMNGALMGGRNIK 202
            .:||.|||||.||.||||||||:||||.:|.|||||||||||:||.|||||||||..::||||||
  Rat   142 YYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIK 206

  Fly   203 VGRPSNMPQAQQVIDEVQEEAKSFNRIYVASIHPDLSEEDIKSVFEAFGPILYCKLAQGTSLHTH 267
            ||||||:.|||.:||::.|||::||||||||:|.|||::||||||||||.|..|.||:..:...|
  Rat   207 VGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKH 271

  Fly   268 KGYGFIEYANKQAMDEAIASMNLFDLGGQLLRVGRSITPPNALACPTTNSTMPTAAAVAAAAATA 332
            ||||||||...|:..:|::||||||||||.||||:::|||..|..|.|...:|.|||||||||||
  Rat   272 KGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTPATPGGLPPAAAVAAAAATA 336

  Fly   333 KIQALDAVASNAVLGLSQNTPVMAAGAVVTKVGAMPVVSAATSAAALHPALAQAAP-ALLPPGIF 396
            ||.|.:|||..||||      .:|...:|:                  |||..|.| ..||..:.
  Rat   337 KITAQEAVAGAAVLG------TLATPGLVS------------------PALTLAQPLGALPQAVM 377

  Fly   397 QAPTPVAPSLLGVPAGLQPLQAVVPTLPPPALLATPTLPMTVGGVGVGLVPTVA---TLAGAEAS 458
            .|..|      ||..|:.|              |.|.:|:|:..||| :.|.:|   ||...|..
  Rat   378 AAQAP------GVITGVTP--------------ARPPIPVTIPSVGV-VNPILASPPTLGLLEPK 421

  Fly   459 KGAAAAAALSAAANNAAVTAANLSENIKKAHEKQQEELQKKLMDEGDVQTLQQQENMSIKGQSAR 523
            |                              ||::|||   ..:....:.|.:||:|||.|.|||
  Rat   422 K------------------------------EKEEEEL---FPESERPEMLSEQEHMSISGSSAR 453

  Fly   524 QLVMQRLMRPVDSRVIILRNMVGPEDVDETLQEEIQEECSKFGTVSRVIIFNEKQTENEDDDEAE 588
            .:|||:|:|..:|.|::|||||.|:|:|:.|:.|:.|||.|||.|:||||:.|||.|.||   ||
  Rat   454 HMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEED---AE 515

  Fly   589 IIVKIFVEFSAGAEAMRGKEALDGRFFGGRRVVAELYDQGIFDQGDLS 636
            ||||||||||..:|..:..:||:||:||||:||||:|||..||..|||
  Rat   516 IIVKIFVEFSMASETHKAIQALNGRWFGGRKVVAEVYDQERFDNSDLS 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hfp	NP_525123.2	half-pint	10..637	CDD:130706	303/633 (48%)
		RRM1_PUF60	130..205	CDD:240816	59/74 (80%)
		RRM2_PUF60	227..303	CDD:240817	50/75 (67%)
		RRM3_UHM_PUF60	536..636	CDD:241092	60/99 (61%)
Puf60	XP_006241956.2	half-pint	7..564	CDD:130706	303/633 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352837
Domainoid	1	1.000	198	1.000	Domainoid score	I2994
eggNOG	1	0.900	-	-		E1_KOG0124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8614
Inparanoid	1	1.050	506	1.000	Inparanoid score	I1283
OMA	1	1.010	-	-		QHG51929
OrthoDB	1	1.010	-	-		D438205at33208
OrthoFinder	1	1.000	-	-		FOG0005543
OrthoInspector	1	1.000	-	-		oto95845
orthoMCL	1	0.900	-	-		OOG6_104067
Panther	1	1.100	-	-	LDO	PTHR47330
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770