Protein Alignment hfp and PUF60

DIOPT Version :9

• Sequence 1: NP_525123.2
• Gene: hfp / 38173
• FlyBaseID: FBgn0028577
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: NP_001349824.1
• Gene: PUF60 / 22827
• HGNCID: 17042
• Length: 596
• Species: Homo sapiens
• Alignment Length: 606
• Identity: 304/606 - (50%)
• Similarity: 375/606 - (61%)
• Gaps: 108/606 - (17%)

  Fly    53 TGDVKFGPG-TRSALLGLLGGALPKLSSEQHDLVSKAKKYAMEQSIKMVLMKQTLAHQQQQLAT- 115
            |..:|...| :.:|.||     ||.|:.||.:.:.||||||||||||.||:|||:|||||||..
Human    76 TDSIKMENGQSTAAKLG-----LPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTNL 135

  Fly   116 ----------------QRTQVQRQQALALMCRVYVGSISFELKEDTIRVAFTPFGPIKSINMSWD 164
                            |....|||:|||:|||||||||.:||.|||||.||.||||||||:||||
Human   136 QMAAVTMGFGDPLSPLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWD 200

  Fly   165 PITQKHKGFAFVEYEIPEGAQLALEQMNGALMGGRNIKVGRPSNMPQAQQVIDEVQEEAKSFNRI 229
            .:|.|||||||||||:||.|||||||||..::||||||||||||:.|||.:||::.|||::||||
Human   201 SVTMKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRI 265

  Fly   230 YVASIHPDLSEEDIKSVFEAFGPILYCKLAQGTSLHTHKGYGFIEYANKQAMDEAIASMNLFDLG 294
            ||||:|.|||::||||||||||.|..|.||:..:...|||||||||...|:..:|::||||||||
Human   266 YVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLG 330

  Fly   295 GQLLRVGRSITPPNALACPTTNSTMPTAAAVAAAAATAKIQALDAVASNAVLGLSQNTPVMAAGA 359
            ||.||||:::|||..|..|.|...:|.|||||||||||||.|.:|||..||||
Human   331 GQYLRVGKAVTPPMPLLTPATPGGLPPAAAVAAAAATAKITAQEAVAGAAVLG------------ 383

  Fly   360 VVTKVGAMPVVSAATSAAALHPALAQAAP-ALLPPGIFQAPTPVAPSLLGVPAGLQPLQAVVPTL 423
               .:|...:||         |||..|.| ..||..:..|..|      ||..|:.|
Human   384 ---TLGTPGLVS---------PALTLAQPLGTLPQAVMAAQAP------GVITGVTP-------- 422

  Fly   424 PPPALLATPTLPMTVGGVGVGLVPTVA---TLAGAEASKGAAAAAALSAAANNAAVTAANLSENI 485
                  |.|.:|:|:..||| :.|.:|   ||...|..|
Human   423 ------ARPPIPVTIPSVGV-VNPILASPPTLGLLEPKK-------------------------- 454

  Fly   486 KKAHEKQQEELQKKLMDEGDVQTLQQQENMSIKGQSARQLVMQRLMRPVDSRVIILRNMVGPEDV 550
                ||::|||   ..:....:.|.:||:|||.|.|||.:|||:|:|..:|.|::|||||.|:|:
Human   455 ----EKEEEEL---FPESERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDI 512

  Fly   551 DETLQEEIQEECSKFGTVSRVIIFNEKQTENEDDDEAEIIVKIFVEFSAGAEAMRGKEALDGRFF 615
            |:.|:.|:.|||.|||.|:||||:.|||.|.||   ||||||||||||..:|..:..:||:||:|
Human   513 DDDLEGEVTEECGKFGAVNRVIIYQEKQGEEED---AEIIVKIFVEFSIASETHKAIQALNGRWF 574

  Fly   616 GGRRVVAELYDQGIFDQGDLS 636
            .||:||||:|||..||..|||
Human   575 AGRKVVAEVYDQERFDNSDLS 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hfp	NP_525123.2	half-pint	10..637	CDD:130706	304/606 (50%)
		RRM1_PUF60	130..205	CDD:240816	59/74 (80%)
		RRM2_PUF60	227..303	CDD:240817	50/75 (67%)
		RRM3_UHM_PUF60	536..636	CDD:241092	59/99 (60%)
PUF60	NP_001349824.1	half-pint	44..596	CDD:130706	304/606 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158837
Domainoid	1	1.000	198	1.000	Domainoid score	I3090
eggNOG	1	0.900	-	-		E1_KOG0124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8614
Inparanoid	1	1.050	504	1.000	Inparanoid score	I1356
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51929
OrthoDB	1	1.010	-	-		D438205at33208
OrthoFinder	1	1.000	-	-		FOG0005543
OrthoInspector	1	1.000	-	-		oto88714
orthoMCL	1	0.900	-	-		OOG6_104067
Panther	1	1.100	-	-	LDO	PTHR47330
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4280
SonicParanoid	1	1.000	-	-		X3961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800