DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hfp and rnp-6

DIOPT Version :9

Sequence 1:	NP_525123.2	Gene:	hfp / 38173	FlyBaseID:	FBgn0028577	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_491176.1	Gene:	rnp-6 / 171922	WormBaseID:	WBGene00004389	Length:	749	Species:	Caenorhabditis elegans

Alignment Length:	759	Identity:	284/759 - (37%)
Similarity:	380/759 - (50%)	Gaps:	189/759 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PYLSQPLYDLKQTGDVKFGPGTR--SALLGLLGGALPKLSSEQHDLVSKAKKYAMEQSIKMVLMK 103
            |.:|.|:..|.|.|:|..|||.:  :..:||   .|.||||::.|.:..||||||:.|||.:|::
Worm    18 PAVSVPMPVLPQDGEVFVGPGGKKDAQKIGL---GLSKLSSKRKDDIQMAKKYAMDISIKQILLR 79

  Fly   104 QTLAHQQQQLATQRTQVQRQQALALMCRVYVGSISFELKEDTIRVAFTPFGPIKSINMSWDPITQ 168
            |    |:||...|:.|....|||::|.|:||||||||::||.:|.||.||||||||||||||.|.
Worm    80 Q----QKQQQENQQRQQMYSQALSIMSRIYVGSISFEIREDMLRRAFDPFGPIKSINMSWDPATG 140

  Fly   169 KHKGFAFVEYEIPEGAQLALEQMNGALMGGRNIKVGR--------PSNMPQAQQVIDEVQEEAKS 225
            .||.|||||||:||.|.||.|.|||.::||||:||..        |.||||||.:||.||::||.
Worm   141 HHKTFAFVEYEVPEAALLAQESMNGQMLGGRNLKVNSMMFQEMRLPQNMPQAQPIIDMVQKDAKK 205

  Fly   226 FNRIYVASIHPDLSEEDIKSVFEAFGPILYCKLAQGTSLHTHKGYGFIEYANKQAMDEAIASMNL 290
            :.|:||:|:||||||.|:||||||||.|:.|:||:..:...|:|:|::|:.|..:..||||.||:
Worm   206 YFRVYVSSVHPDLSETDLKSVFEAFGEIVKCQLARAPTGRGHRGFGYLEFNNLTSQSEAIAGMNM 270

  Fly   291 FDLGGQLLRVGRSITPPNALAC--PTTNSTMPTAAAVAAAAATAKIQALDAVASNAVLGLSQNTP 353
            ||||||.||||:.:|||:||..  |.:.|.:|.:.:||.||.|||:.|.:|.|     |.|..||
Worm   271 FDLGGQYLRVGKCVTPPDALTYLQPASVSAIPASVSVACAAITAKVMAAEAAA-----GSSPKTP 330

  Fly   354 VMAAG-----------AVVTKVGAMPV---VSAATSAAALHPALAQAAPALLPPGI--------- 395
            ..:.|           :..|...::|.   ..|..|:....|...:..|  |||..
Worm   331 SESGGSRAASPAPRAQSPATPSSSLPTDIENKAVISSPKKEPEEIEVPP--LPPSAPDVVKDEPM 393

  Fly   396 -----------FQAPTPVA---PSLLGVPAGLQPLQAVVPT-----LPPPALLATPTL------- 434
                       .:.|.|||   |..|.:|:.:.|...:.||     :|.|:.||....
Worm   394 EIEEEEEYTIPEEKPKPVAIVPPPGLAIPSLVAPPGLIAPTEIGIVVPNPSFLAQQQQKIEEKIE 458

  Fly   435 ---------------------------------------------------PMTVG--------- 439
                                                               |:|.|
Worm   459 EEEEARTERVKLSTSQRKKMKREKLNQMTFEEKMAQVLGQQKAVQNQRMADPVTFGALDDTVAWK 523

  Fly   440 ------------------GVGVGLVPTVATLAGAEASKGAAAAAALSAAANNAAVTAANLSENIK 486
                              |.|.| ...||::|.|....|::...|.:|.|..||  ||...|..|
Worm   524 DPSNEDQTSEDGKMLAIMGPGRG-GDNVASMALALMDGGSSLMLANNAKAKEAA--AALALEPKK 585

  Fly   487 KAHEKQQEELQKKL-----------------------MDEGDVQTLQQQENMSIKGQSARQLVMQ 528
            |...|:.:::|.||                       |:..|. :|..||.:.|:|..||.|:|.
Worm   586 KKKVKEGKKIQPKLNTAQALAAAAKAGEMSDALKNEVMNSEDA-SLASQEGLEIRGNDARHLLMT 649

  Fly   529 RLMRPVDSRVIILRNMVGPEDVDETLQEEIQEECSKFGTVSRVIIFNEKQTENEDDDEAEIIVKI 593
            :|||...|.||:|||||.|:|:||.|:.||:|||.|:|.|..|:|.|...:.         :|||
Worm   650 KLMRTNRSNVIVLRNMVTPQDIDEFLEGEIREECGKYGNVIDVVIANFASSG---------LVKI 705

  Fly   594 FVEFSAGAEAMRGKEALDGRFFGGRRVVAELYDQGIFDQGDLSG 637
            ||::|...:..|.|.|||||||||..|.||.|||.:||..|.:|
Worm   706 FVKYSDSMQVDRAKAALDGRFFGGNTVKAEAYDQILFDHADYTG 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hfp	NP_525123.2	half-pint	10..637	CDD:130706	283/757 (37%)
		RRM1_PUF60	130..205	CDD:240816	53/74 (72%)
		RRM2_PUF60	227..303	CDD:240817	44/75 (59%)
		RRM3_UHM_PUF60	536..636	CDD:241092	50/99 (51%)
rnp-6	NP_491176.1	half-pint	5..749	CDD:130706	283/757 (37%)
		RRM1_PUF60	102..177	CDD:240816	53/74 (72%)
		RRM2_PUF60	207..283	CDD:240817	44/75 (59%)
		RRM_SF	657..748	CDD:302621	50/99 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166356
Domainoid	1	1.000	112	1.000	Domainoid score	I3881
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8614
Inparanoid	1	1.050	328	1.000	Inparanoid score	I1449
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51929
OrthoDB	1	1.010	-	-		D438205at33208
OrthoFinder	1	1.000	-	-		FOG0005543
OrthoInspector	1	1.000	-	-		oto17608
orthoMCL	1	0.900	-	-		OOG6_104067
Panther	1	1.100	-	-	LDO	PTHR47330
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4280
SonicParanoid	1	1.000	-	-		X3961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940