DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stet and RHBDF2

DIOPT Version :9

Sequence 1:	NP_788450.1	Gene:	stet / 38169	FlyBaseID:	FBgn0020248	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_078875.4	Gene:	RHBDF2 / 79651	HGNCID:	20788	Length:	856	Species:	Homo sapiens

Alignment Length:	209	Identity:	53/209 - (25%)
Similarity:	86/209 - (41%)	Gaps:	42/209 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 PDKRHEIWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFD 326
            ||:.:.:|..||   ||||.:|...:|..|:.....||.:.|..|||.|:....:.|:|.::||.
Human   651 PDQFYRLWLSLF---LHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFL 712

  Fly   327 PDVFLVGASGGVYALLAAHLANVLLNYHQMRYGVIKLLHILVFVSFDFGFAIYARYAGDELQLGS 391
            |....||.:|..:.|||.                       :||.....:.:..|.....|.|.:
Human   713 PYRAEVGPAGSQFGLLAC-----------------------LFVELFQSWPLLERPWKAFLNLSA 754

  Fly   392 SSEFLAIDQAETAGAVSY---VAHLAGAIAGLTIGLLVLK----SFEQKLHEQLLWWIAL----G 445
            ...||.|     .|.:.:   :||:.|.::||.:....|.    ....|..::.|..::|    |
Human   755 IVLFLFI-----CGLLPWIDNIAHIFGFLSGLLLAFAFLPYITFGTSDKYRKRALILVSLLAFAG 814

  Fly   446 TYLALVVFAIAFNI 459
            .:.|||::...:.|
Human   815 LFAALVLWLYIYPI 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stet	NP_788450.1	EFh	<75..115	CDD:298682
		EF-hand_7	91..156	CDD:290234
		Rhomboid	262..428	CDD:279958	44/168 (26%)
RHBDF2	NP_078875.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..115
		Rhomboid_SP	128..334	CDD:289371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..184
		Involved in interaction with FRMD8. /evidence=ECO:0000269\|PubMed:29897333	191..271
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..553
		Rhomboid	648..789	CDD:279958	44/168 (26%)
		GtrA	748..832	CDD:303012	20/86 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820