DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stet and Rhbdl3

DIOPT Version :9

Sequence 1:	NP_788450.1	Gene:	stet / 38169	FlyBaseID:	FBgn0020248	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001099289.1	Gene:	Rhbdl3 / 287556	RGDID:	1311901	Length:	404	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	153/400 - (38%)
Similarity:	243/400 - (60%)	Gaps:	32/400 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 EAELRRELL-RDKWKLLFDMFDPEGFGEISVEEFLEALKSPEFLSQVPMNKRELLLERAKKAKLP 141
            |||.|.... .|.||:||:.|||...|.||..:|...|:|..  |::..:|:|:||..|..
  Rat    26 EAEERLPAAPEDHWKVLFEKFDPGSTGYISTGKFRSLLESHS--SKLDPHKKEVLLALADS---- 84

  Fly   142 TGPGYVTFQDFVNVMSGKRTRSFKCAVHHRDREVCSENDFQLVLNEP--PLFRKMVHAVAMEILP 204
            ...|.:.:|||||:||.||:.||:.|:...:|.:.|    :.:|.|.  .|.::::..||.|.||
  Rat    85 HADGQICYQDFVNLMSNKRSNSFRQAILQGNRRLSS----KALLEEKGLSLSQRLIRHVAYETLP 145

  Fly   205 EERDRKYYADRYTCCPPPFFIILVTLVELGFFVYHSVVTGEAAPRGPIPS--DSMFIYRPDKRHE 267
            .|.|||:|.|.|||||||:|:|.:||:|:..|:|:.|:..:...:...|.  .:..:|.|..|.:
  Rat   146 REIDRKWYYDSYTCCPPPWFMITITLLEVALFLYNGVLLDQFVLQVTHPRYLKNSLVYHPQLRAQ 210

  Fly   268 IWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDPDVFLV 332
            .||::.|:.:|||...||.|||:||:.|:|||||||:|||..:|.:||:||||..|:.|....:|
  Rat   211 AWRYVTYIFMHAGVEQLGLNVALQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVV 275

  Fly   333 GASGGVYALLAAHLANVLLNYHQMR--YGVIKLLHILVFVSFDFGFAIYARYAGDELQLGSSSEF 395
            |:|||||||::|||||:::|:..|:  :.::::...|:.:|.:||.|::.|:        ..|.:
  Rat   276 GSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRF--------HPSAY 332

  Fly   396 LAIDQAETAGAVSYVAHLAGAIAGLTIGLLVLKSFEQKLHEQLLWWIALGTYLALVVFAIAFNIM 460
            ......      |:||||.|...|:|:|::||:::||:|.:|.||||.:..|...|:||:.:||.
  Rat   333 PPCPHP------SFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVTMYTIFVLFAVFWNIF 391

  Fly   461 NGFAMFNIRV 470
             .:.:.::::
  Rat   392 -AYTLLDLKL 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stet	NP_788450.1	EFh	<75..115	CDD:298682	16/37 (43%)
		EF-hand_7	91..156	CDD:290234	24/64 (38%)
		Rhomboid	262..428	CDD:279958	68/167 (41%)
Rhbdl3	NP_001099289.1	EF-hand_7	36..100	CDD:404394	26/69 (38%)
Rhbdl3	NP_001099289.1	Rhomboid	205..359	CDD:396315	68/167 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338202
Domainoid	1	1.000	142	1.000	Domainoid score	I4562
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34700
Inparanoid	1	1.050	270	1.000	Inparanoid score	I2933
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	1	1.000	-	-		FOG0000995
OrthoInspector	1	1.000	-	-		oto97971
orthoMCL	1	0.900	-	-		OOG6_109404
Panther	1	1.100	-	-	O	PTHR45840
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2844
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760