DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stet and RHBDL3

DIOPT Version :9

Sequence 1:	NP_788450.1	Gene:	stet / 38169	FlyBaseID:	FBgn0020248	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001350764.1	Gene:	RHBDL3 / 162494	HGNCID:	16502	Length:	428	Species:	Homo sapiens

Alignment Length:	245	Identity:	105/245 - (42%)
Similarity:	150/245 - (61%)	Gaps:	15/245 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 EAELRRELL-RDKWKLLFDMFDPEGFGEISVEEFLEALKSPEFLSQVPMNKRELLLERAKKAKLP 141
            |||.|.... .|.||:|||.|||...|.||..:|...|:|..  |::..:|||:||..|..
Human    26 EAEERLPAAPEDHWKVLFDQFDPGNTGYISTGKFRSLLESHS--SKLDPHKREVLLALADS---- 84

  Fly   142 TGPGYVTFQDFVNVMSGKRTRSFKCAVHHRDREVCSENDFQLVLNEP--PLFRKMVHAVAMEILP 204
            ...|.:.:||||::||.||:.||:.|:...:|.:.|    :.:|.|.  .|.::::..||.|.||
Human    85 HADGQIGYQDFVSLMSNKRSNSFRQAILQGNRRLSS----KALLEEKGLSLSQRLIRHVAYETLP 145

  Fly   205 EERDRKYYADRYTCCPPPFFIILVTLVELGFFVYHSVVTGEAAPRGPIPS--DSMFIYRPDKRHE 267
            .|.|||:|.|.|||||||:|:|.|||:|:.||:|:.|..|:...:...|.  .:..:|.|..|.:
Human   146 REIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFVLQVTHPRYLKNSLVYHPQLRAQ 210

  Fly   268 IWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLA 317
            :||:|.|:.:|||..|||.||.:||:.|:|||||||:|||..:|.:||:|
Human   211 VWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVA 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stet	NP_788450.1	EFh	<75..115	CDD:298682	17/37 (46%)
		EF-hand_7	91..156	CDD:290234	25/64 (39%)
		Rhomboid	262..428	CDD:279958	31/56 (55%)
RHBDL3	NP_001350764.1	EF-hand_7	36..100	CDD:316058	27/69 (39%)
		EF-hand motif	38..67	CDD:320054	14/28 (50%)
		Rhomboid	205..>260	CDD:328780	30/54 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144494
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34700
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2908
Isobase	1	0.950	-	0	Normalized mean entropy	S5174
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	1	1.000	-	-		FOG0000995
OrthoInspector	1	1.000	-	-		otm41807
orthoMCL	1	0.900	-	-		OOG6_109404
Panther	1	1.100	-	-	O	PTHR45840
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2770
SonicParanoid	1	1.000	-	-		X2844
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740