DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stet and rhbdl1

DIOPT Version :9

Sequence 1:	NP_788450.1	Gene:	stet / 38169	FlyBaseID:	FBgn0020248	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001254516.1	Gene:	rhbdl1 / 100887821	ZFINID:	ZDB-GENE-120529-2	Length:	396	Species:	Danio rerio

Alignment Length:	379	Identity:	136/379 - (35%)
Similarity:	227/379 - (59%)	Gaps:	31/379 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 DPEGFGEISVEEFLEALKSPEFLSQVPMNKRELLLERAKKAKLPTGPGYVTFQDFVNVMSGKRTR 162
            |||..|.|:||.|....:..|.  |:..:|.|:||...:..:    .|:|.:|:.:.:::.||:.
Zfish    39 DPEQTGFITVENFTSLAEHHEL--QLDPSKLEMLLALVQSNE----HGHVCYQELIELLNSKRSS 97

  Fly   163 SFKCAVHHRDREVCSENDFQLVLNEPPL--FRKMVHAVAMEILPEERDRKYYADRYTCCPPPFFI 225
            ||:.|:.:..|.:..|    ::|:|..|  :::.|..||.||||.|.||::|..:...||||.|:
Zfish    98 SFRRAIANGRRTLQRE----ILLDETGLGVYKRFVRYVAYEILPCETDRRWYFHQNRLCPPPVFM 158

  Fly   226 ILVTLVELGFFVYHSVVTGEAAPRGPIPS--DSMFIYRPDKRHEIWRFLFYMVLHAGWLHLGFNV 288
            .::|:|::..|:.:.|:..:...:...|.  .|..:|.|..|.:||||..||.:|.|...||||.
Zfish   159 AVITIVQIMVFMCYGVMLNKWVLQTYQPDFMKSPLVYHPGHRAQIWRFFSYMFMHVGLEQLGFNA 223

  Fly   289 AVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDPDVFLVGASGGVYALLAAHLANVLLNY 353
            .:||:.|:|||||||..||:.:|.:||:||||..||.|....:||.|||||||.:||||||::|:
Zfish   224 LLQLMIGVPLEMVHGILRISLLYMAGVIAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNW 288

  Fly   354 HQMR--YGVIKLLHILVFVSFDFGFAIYARYAGDELQLGSSSEFLAIDQAETAGAVSYVAHLAGA 416
            ..|:  |.:::::..||.:|.:.|.|::.|::.   .|.||..           ..|::|||:||
Zfish   289 AGMKCPYKLLRMILALVCMSSEVGRAVWLRFSP---PLPSSGP-----------QPSFMAHLSGA 339

  Fly   417 IAGLTIGLLVLKSFEQKLHEQLLWWIALGTYLALVVFAIAFNIMNGFAMFNIRV 470
            :.|:::|||:|:|:|:.||:|..||:.:.:::..::|||.:||. .:.:..:::
Zfish   340 VVGISMGLLILRSYEESLHKQCSWWVLIFSFVTFLLFAIFWNIF-AYELLGVQI 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stet	NP_788450.1	EFh	<75..115	CDD:298682	8/16 (50%)
		EF-hand_7	91..156	CDD:290234	17/57 (30%)
		Rhomboid	262..428	CDD:279958	73/167 (44%)
rhbdl1	NP_001254516.1	Rhomboid	197..351	CDD:279958	73/167 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9099
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3262
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	1	1.000	-	-		FOG0000995
OrthoInspector	1	1.000	-	-		mtm6530
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45840
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2770
SonicParanoid	1	1.000	-	-		X2844
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.960